Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Helena den-Haan"'
Autor:
Valentina Citro, Jorge Peña-García, Helena den-Haan, Horacio Pérez-Sánchez, Rosita Del Prete, Ludovica Liguori, Chiara Cimmaruta, Jan Lukas, Maria Vittoria Cubellis, Giuseppina Andreotti
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0165463 (2016)
Personalized therapies are required for Fabry disease due to its large phenotypic spectrum and numerous different genotypes. In principle, missense mutations that do not affect the active site could be rescued with pharmacological chaperones. At pres
Externí odkaz:
https://doaj.org/article/24dd730a519448e88997865c8214b0ea
Autor:
Helena den-Haan, María Encarnación Martínez Moreno, Horacio Pérez-Sánchez, Antigoni Katsikoudi, Andreas G. Tzakos, Antonio Segura Carretero, Pedro Ruiz-Espinosa, Andrés Muñoz, Andreia S.P. Pereira, Antonia Sánchez-Pérez, Ivana Stojanovic, Jesús Lozano-Sánchez, Jorge Peña-García, José Antonio Gabaldón Hernández
Publikováno v:
Journal of Chemical Information and Modeling. 60:4124-4130
The DIA-DB is a web server for the prediction of diabetes drugs that uses two different and complementary approaches: (a) comparison by shape similarity against a curated database of approved antidiabetic drugs and experimental small molecules and (b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5021fa1dc5844a57728e6eca7ae6d439
https://doi.org/10.1021/acs.jcim.0c00107
https://doi.org/10.1021/acs.jcim.0c00107
Autor:
Helena den Haan, Sandipan Chakraborty, José Manuel Villalgordo, Alfonso Pérez-Garrido, Ilkay Erdogan Orhan, Jorge Peña-García, Fatma Sezer Senol Deniz, Horacio Pérez-Sánchez
Publikováno v:
Journal of chemical information and modeling. 61(1)
Acetylcholinesterase is a prime target for therapeutic intervention in Alzheimer's disease. Acetylcholinesterase inhibitors (ACKEIs) are used to improve cognitive abilities, playing therefore an important role in disease management. Drug repurposing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9446e91cfcbb5297ff89c61a7c799fcd
https://pubmed.ncbi.nlm.nih.gov/33320652
https://pubmed.ncbi.nlm.nih.gov/33320652
Autor:
Helena den-Haan, Ilkay Erdogan Orhan, Priyanka Banerjee, Renata Abel, Wieslaw Oleszek, Łukasz Pecio, Robert Preissner, F. Sezer Senol Deniz, José P. Cerón-Carrasco, Horacio Pérez-Sánchez, Edward Krzyżak, Adam Matkowski, Sylwester Ślusarczyk
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 4475, p 4475 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 12
International Journal of Molecular Sciences
Volume 21
Issue 12
Inhibition of cholinesterases remains one of a few available treatment strategies for neurodegenerative dementias such as Alzheimer&rsquo
s disease and related conditions. The current study was inspired by previous data on anticholinesterase pro
s disease and related conditions. The current study was inspired by previous data on anticholinesterase pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c37554b6df5d571d7c094efd5e5389
https://www.mdpi.com/1422-0067/21/12/4475
https://www.mdpi.com/1422-0067/21/12/4475
Autor:
Sylwester, Ślusarczyk, F Sezer, Senol Deniz, Renata, Abel, Łukasz, Pecio, Horacio, Pérez-Sánchez, José P, Cerón-Carrasco, Helena, den-Haan, Priyanka, Banerjee, Robert, Preissner, Edward, Krzyżak, Wiesław, Oleszek, Ilkay, E Orhan, Adam, Matkowski
Publikováno v:
International Journal of Molecular Sciences
Inhibition of cholinesterases remains one of a few available treatment strategies for neurodegenerative dementias such as Alzheimer’s disease and related conditions. The current study was inspired by previous data on anticholinesterase properties o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cc0d7ea7dc7666819fdf020fd45700f9
https://pubmed.ncbi.nlm.nih.gov/32586060
https://pubmed.ncbi.nlm.nih.gov/32586060
Autor:
Francisco J. Nicolás, Horacio Pérez-Sánchez, María L. Cayuela, Priscila Campioni Rodrigues, Irene Luque, Helena den-Haan, Tuula Salo, Begoña Alburquerque-González, Silvia Montoro-García, Ángel Bernabé-García, Pablo Conesa-Zamora, Manuel Bernabé-García
Tumor invasion and metastasis involve processes in which actin cytoskeleton rearrangement induced by Fascin1 plays a crucial role. Indeed, Fascin1 has been found overexpressed in tumors with worse prognosis. Migrastatin and its analogues target Fasci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07761ad32d917d5e155c875dc8d2e9ec
http://hdl.handle.net/10138/325423
http://hdl.handle.net/10138/325423
Publikováno v:
Chemical Physics Letters. 690:74-81
Many efforts have been devoted to discover molecules able to halt methylation processes in DNA. However, less is known about the application of methyl promoters in the framework of hypomethylation diseases. Herein, we used molecular dynamics and ab i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63897fbb7544b7dcaf5fad835c779e1f
https://doi.org/10.1016/j.cplett.2017.10.042
https://doi.org/10.1016/j.cplett.2017.10.042
Autor:
Sadia Naz, Jorge Peña-García, Horacio Pérez-Sánchez, Ajmal Khan, Umar Farooq, Tareq Abu-Izneid, Noor Jehan, Abdur Rauf, Saud Bawazeer, Haroon Khan, Mohamed Fawzy Ramadan, José P. Cerón-Carrasco, Taibi Ben Hadda, Helena den Haan, Aliya Ibrar
Publikováno v:
Revista Brasileira de Farmacognosia, Volume: 27, Issue: 5, Pages: 636-640, Published: OCT 2017
Revista Brasileira de Farmacognosia, Vol 27, Iss 5, Pp 636-640
Revista Brasileira de Farmacognosia, Vol 27, Iss 5, Pp 636-640 (2017)
Revista Brasileira de Farmacognosia v.27 n.5 2017
Revista Brasileira de Farmacognosia
Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
Revista Brasileira de Farmacognosia, Vol 27, Iss 5, Pp 636-640
Revista Brasileira de Farmacognosia, Vol 27, Iss 5, Pp 636-640 (2017)
Revista Brasileira de Farmacognosia v.27 n.5 2017
Revista Brasileira de Farmacognosia
Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
Phlomidoschema parviflorum (Benth.) Vved. (Basionym: Stachys parviflora Benth.) Lamiaceae, have significance medicinal importance as it is used in number of health disorders including diarrhea, fever, sore mouth and throat, internal bleeding, weaknes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728d1c412c350836fd3b763d7bc8b996
https://doi.org/10.1016/j.bjp.2017.07.003
https://doi.org/10.1016/j.bjp.2017.07.003
Autor:
Helena den-Haan, Cyril C. Y. Yip, Zheng Zhu, Chris Chung-Sing Chan, Kah-Meng Tee, Jorge Escobedo de la Peña, Vincent Kwok-Man Poon, Winger Wing-Nga Mak, Horacio Pérez-Sánchez, José P. Cerón-Carrasco, Jasper Fuk-Woo Chan, Kwok-Hung Chan, Kenn Ka-Heng Chik, Zijiao Zou, Shuofeng Yuan, Kwok-Yung Yuen, Anna Jinxia Zhang, Jian-Piao Cai
Publikováno v:
Antiviral Research. 145:33-43
Zika virus (ZIKV) infection may be associated with severe complications in fetuses and adults, but treatment options are limited. We performed an in silico structure-based screening of a large chemical library to identify potential ZIKV NS2B-NS3 prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df9962e1b7ce075662d0bb89cbdad942
https://doi.org/10.1016/j.antiviral.2017.07.007
https://doi.org/10.1016/j.antiviral.2017.07.007
Autor:
José P. Cerón-Carrasco, Helena den-Haan, Nurgün Küçükboyaci, Horacio Pérez-Sánchez, Ilkay Erdogan Orhan, Jorge Peña-García, Ihsan Calis
Publikováno v:
Phytochemistry Letters. 20:373-378
S. grandis Freitag, Vural & N. Adiguzel is an endemic plant species to Turkey. Since some other Salsola species have been reported to exert cholinesterase inhibitory effect, we aimed to investigate its inhibitory potential against AChE. The EtOH extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca92e5737845d50b5dd3f437ad7d6af
https://doi.org/10.1016/j.phytol.2016.10.017
https://doi.org/10.1016/j.phytol.2016.10.017