Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Helena Thörn"'
Autor:
Alex Mattinson, David Lindley, Helena Engman, Manthena V.S. Varma, Anh-Thu Nguyen-Trung, Binfeng Xia, Xavier Pepin, Linette Ruston, Wei Zhu, Bill van Osdol, Celine Ollier, David Good, Jonathan Brown, Laurent Boulu, Talia Flanagan, Olivier Nicolas, Staffan Berg, Shanoo Budhdeo, Aarti Patel, Jan Bevernage, Handan He, Sweta Modi, Richard Barker, Claire Jackson, Christer Tannergren, Xiojun Ren, Stephane Beilles, J. Matthew Wood, Johanna Laru, Pierre Daublain, Sara Carlert, Louis Henrion, Jean-Flaubert Nguefack, Gunilla Hanisch, Eva Karlsson, Wen Lin, Shruthi Vaidhyanathan, Robert Carr, Fan Wu, Jin Zhang, Amais Ahmad, James M. Mullin, Sari Pappinen, Andrea Moir, Ke Szeto, Christine Xu, Claire Patterson, David B. Turner, Guillaume Louit, Yuya Wang, Tycho Heimbach, Richard Lloyd, Frans Franek, Masoud Jamei, Christophe Tistaert, Bertil Abrahamsson, Kerstin Julia Schäfer, Leon Aarons, Shriram M. Pathak, Adam S. Darwich, Suet Wong, Dónal Murphy, Amin Rostami-Hodjegan, Timo Korjamo, Helena Thörn, Kartrin Schmid, Michael B. Bolger, Johanna Tuunainen, Mai Anh Nguyen
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 156:50-63
Oral drug absorption is a complex process depending on many factors, including the physicochemical properties of the drug, formulation characteristics and their interplay with gastrointestinal physiology and biology. Physiological-based pharmacokinet
Publikováno v:
The AAPS Journal. 23
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 156
Systemic exposure of inhaled drugs is used to estimate the local lung exposure and assess systemic side effects for drugs with local pharmacological targets. Predicting systemic exposure is therefore central for successful development of drugs intend
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 124:1-12
Permeation of inhaled drugs across the pulmonary epithelium can regulate the rate and extent of local drug absorption and hence the pulmonary tissue concentration. Therefore, understanding pulmonary epithelial transport could be important for success
Autor:
Richard Lloyd, Leon Aarons, Mark McAllister, Amitava Mitra, Chester Costales, Timo Korjamo, Maria Hammarberg, Helena Thörn, Carole Shardlow, Jussi Malkki, Adam S. Darwich, Tycho Heimbach, Achiel Van Peer, James M. Mullin, Jennifer B. Dressman, Johanna Laru, Dónal Murphy, Handan He, Jian Lin, Irina Mishenzon, Ke X. Szeto, Mei Wong, Peter Langguth, Bertil Abrahamsson, Carolin Hoft, Fan Wu, Mohammed Yasin, Olivier Nicolas, Manthena V.S. Varma, Alison Margolskee, Christer Tannergren, Edmund Kostewicz, Yan Pang, Shriram M. Pathak, Johanna Tuunainen, Constanze Hilgendorf, Sari Pappinen, Viera Lukacova, Charles J. Rotter, Jan Bevernage, Sweta Modi, Sergej Ramusovic, Simone Hansmann, Mai Anh Nguyen, Amin Rostami-Hodjegan, Eva Huehn, Michael B. Bolger, Jonathan Brown, Loic Laplanche, Christine Xu, Eva Karlsson, Sara Carlert, Pernilla Johansson, Florent Mazuir, Jeike Biewenga, Xavier Pepin, Hans Lennernäs, Aleksandra Galetin
Publikováno v:
Margolskee, A, Darwich, A, Aarons, L, Galetin, A, Rostami-Hochaghan, A, Carlert, S, Hammarberg, M, Hilgendorf, C, Johansson, P, Karlsson, E, Murphy, D, Tannergren, C, Thorn, H, Yasin, M, Mazuir, F, Nicolas, O, Ramusovic, S, Xu, C, Pathak, S, Korjamo, T, Laru, J, Malkki, J, Pappinen, S, Tuunainen, J, Dressman, J, Hansmann, S, Kostewicz, E, He, H, Heimbach, T, Wu, F, Hoft, C, Laplanche, L, Pang, Y, Bolger, M B, Huehn, E, Lukacova, V, Mullin, J M, Szeto, K X, Costales, C, Lin, J, McAllister, M, Modi, S, Rotter, C, Varma, M, Wong, M, Mitra, A, Bevernage, J, Biewenga, J, Van Peer, A, Lloyd, R, Shardlow, C, Langguth, P, Mishenzon, I, Nguyen, M A, Brown, J, Lennernas, H & Abrahamsson, B 2016, ' IMI – Oral Biopharmaceutics Tools project – Evaluation of Bottom-up PBPK Prediction Success Part 2: An Introduction to the Simulation Exercise and Overview of Results ', European Journal of Pharmaceutical Sciences . https://doi.org/10.1016/j.ejps.2016.10.036
Orally administered drugs are subject to a number of barriers impacting bioavailability (Foral), causing challenges during drug and formulation development. Physiologically-based pharmacokinetic (PBPK) modelling can help during drug and formulation d
Publikováno v:
Molecular pharmaceutics. 16(7)
Many inhaled drugs are poorly water soluble, and the dissolution rate is often the rate-limiting step in the overall absorption process. To improve understanding of pulmonary drug dissolution, four poorly soluble inhalation compounds (AZD5423 (a deve
Autor:
Helena Thörn, Ulrika Tehler, Rebecca Fransson, Frans Franek, Patrik U. Andersson, Per Bäckman
Publikováno v:
Molecular pharmaceutics. 15(11)
Pulmonary dissolution of poorly soluble drug substances (DSs) may limit the drug absorption rate and consequently influence clinical performance. Dissolution rate is thus an important quality attribute, and its influence on in vivo drug release must
Publikováno v:
Molecular pharmaceutics. 14(1)
This is a reply to the comment on "In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically Based Absorption Models" by Turner and other Simcyp associates. In the reply we address the major concerns rais
Publikováno v:
Molecular pharmaceutics. 13(6)
Gastrointestinal (GI) drug absorption is a complex process determined by formulation, physicochemical and biopharmaceutical factors, and GI physiology. Physiologically based in silico absorption models have emerged as a widely used and promising supp
Publikováno v:
Molecular Pharmaceutics. 9:3034-3045
The aim of this study was to investigate the mechanisms that might explain the observed route-dependent stereoselective pharmacokinetics (PK) of R/S-verapamil (R/S-VER) following oral and intravenous (iv) administration, by using a novel pig-specific