IgCaller for reconstructing immunoglobulin gene rearrangements and oncogenic translocations from whole-genome sequencing in lymphoid neoplasms

Autor: Junyan Lu, Rosó Mares, Thorsten Zenz, Anna Enjuanes, Ryan D. Morin, Alfredo Rivas-Delgado, Julio Delgado, Rut Mas-de-les-Valls, Peter J. Campbell, Neus Villamor, Tycho Baumann, Ferran Nadeu, Helena Suárez-Cisneros, Dolors Colomer, Alba Navarro, Elias Campo, Romina Royo, Marta Aymerich, Francesco Maura, Xose S. Puente, Silvia Martín, Sílvia Beà

Publikováno v: Nature Communications
Scopus
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
RUO: Repositorio Institucional de la Universidad de Oviedo
Universidad de Oviedo (UNIOVI)
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
RUO. Repositorio Institucional de la Universidad de Oviedo
instname

Immunoglobulin (Ig) gene rearrangements and oncogenic translocations are routinely assessed during the characterization of B cell neoplasms and stratification of patients with distinct clinical and biological features, with the assessment done using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c68977f2c518bf220857b028aef5db5
https://hdl.handle.net/2117/328399

Cyclin D1 overexpression induces global transcriptional downregulation in lymphoid neosplasms

Autor: Robert Albero, Mariko Shimada, Dolors Colomer, Sílvia Beà, Kennosuke Karube, Anna Enjuanes, Giancarlo Castellano, Cristina Capdevila, Guillem Clot, Elias Campo, Pedro Jares, Mónica López-Guerra, Magda Pinyol, Santiago Demajo, Helena Suárez-Cisneros, José I. Martín-Subero, Noelia García

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname

Cyclin D1 is an oncogene frequently overexpressed in human cancers that has a dual function as cell cycle and transcriptional regulator, although the latter is widely unexplored. Here, we investigated the transcriptional role of cyclin D1 in lymphoid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c71d22f022bb3b86f0f67d5f90a2c8
http://hdl.handle.net/2445/155233

SOX11 regulates PAX5 expression and blocks terminal B-cell differentiation in aggressive mantle cell lymphoma

Autor: Jara Palomero, Helena Suárez-Cisneros, Elias Campo, Sílvia Beà, Anna Enjuanes, Alba Navarro, Gaël Roué, José I. Martín-Subero, Virginia Amador, Guillem Clot, Alexandra Moros, Giancarlo Castellano, Dolors Colomer, Neus Villamor, Maria Carmela Vegliante, Pedro Jares, Patricia Pérez-Galán, Luis Hernández

Publikováno v: Blood. 121(12)

Mantle cell lymphoma (MCL) is one of the most aggressive lymphoid neoplasms whose pathogenesis is not fully understood. The neural transcription factor SOX11 is overexpressed in most MCL but is not detected in other mature B-cell lymphomas or normal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6c11479d8145c59e782fc11b7698cb
https://pubmed.ncbi.nlm.nih.gov/23520328

Clinical Impact of Clonal and Subclonal TP53, SF3B1, BIRC3, and ATM Mutations in Chronic Lymphocytic Leukemia

Autor: Ferran Nadeu, Julio Delgado, Cristina Royo, Tycho Bauman, Tatjana Stankovic, Magda Pinyol, Pedro Jares, Alba Navarro, David Martín-García, Sílvia Beà, Itziar Salaverria, Ceri Oldreive, Marta Aymerich, Helena Suárez-Cisneros, Maria Rozman, Neus Villamor, Dolors Colomer, Armando López-Guillermo, Marcos González, Miguel Alcoceba, María José Terol, Enrique Colado, Xose S Puente, Carlos López-Otín, Anna Enjuanes, Elías Campo

Publikováno v: Blood. 126:4138-4138

Genomic studies have provided a complete profile of somatic mutations in chronic lymphocytic leukemia (CLL). These comprehensive approaches have revealed a relatively large number of mutated genes, the adverse prognostic value of some of which has be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69ee32698758ebd92b32022146ec8351
https://doi.org/10.1182/blood.v126.23.4138.4138