Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Helena Sturesson"'
Autor:
Qirui Zhang, Ton Falqués‐Costa, Mattias Pilheden, Helena Sturesson, Tina Ovlund, Vendela Rissler, Anders Castor, Hanne V. H. Marquart, Birgitte Lausen, Thoas Fioretos, Axel Hyrenius‐Wittsten, Anna K. Hagström‐Andersson
Publikováno v:
HemaSphere, Vol 8, Iss 9, Pp n/a-n/a (2024)
Abstract Activating FLT3 and RAS mutations commonly occur in leukemia with KMT2A‐gene rearrangements (KMT2A‐r). However, how these mutations cooperate with the KMT2A‐r to remodel the epigenetic landscape is unknown. Using a retroviral acute mye
Externí odkaz:
https://doaj.org/article/8ac45f1ff8bd4b6db5372692fc30dd64
Autor:
Ton Falqués-Costa, Mattias Pilheden, Qirui Zhang, Louise Ahlgren, Helena Sturesson, Lars Rönnstrand, Axel Hyrenius-Wittsten, Julhash U. Kazi, Anna K. Hagström-Andersson
Publikováno v:
HemaSphere, Vol 7, p e467631f (2023)
Externí odkaz:
https://doaj.org/article/0a734fb886ab479e9c29cb6819fb4fc5
Autor:
Mattias Pilheden, Louise Ahlgren, Axel Hyrenius-Wittsten, Veronica Gonzalez-Pena, Helena Sturesson, Hanne Vibeke Hansen Marquart, Birgitte Lausen, Anders Castor, Cornelis Jan Pronk, Gisela Barbany, Katja Pokrovskaja Tamm, Linda Fogelstrand, Olli Lohi, Ulrika Norén-Nyström, Johanna Asklin, Yilun Chen, Guangchun Song, Michael Walsh, Jing Ma, Jinghui Zhang, Lao H. Saal, Charles Gawad, Anna K. Hagström-Andersson
Publikováno v:
HemaSphere, Vol 6, Iss 10, p e785 (2022)
Infant acute lymphoblastic leukemia (ALL) with KMT2A-gene rearrangements (KMT2A-r) have few mutations and a poor prognosis. To uncover mutations that are below the detection of standard next-generation sequencing (NGS), a combination of targeted dupl
Externí odkaz:
https://doaj.org/article/3d8b60cb5ba24eb4960d6445495d3946
Autor:
Axel Hyrenius-Wittsten, Mattias Pilheden, Helena Sturesson, Jenny Hansson, Michael P. Walsh, Guangchun Song, Julhash U. Kazi, Jian Liu, Ramprasad Ramakrishan, Cristian Garcia-Ruiz, Stephanie Nance, Pankaj Gupta, Jinghui Zhang, Lars Rönnstrand, Anne Hultquist, James R. Downing, Karin Lindkvist-Petersson, Kajsa Paulsson, Marcus Järås, Tanja A. Gruber, Jing Ma, Anna K. Hagström-Andersson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
In acute leukemia with KMT2A rearrangements (KMT2A-R), activating signaling mutations are common. Here, the authors use a retroviral acute myeloid mouse leukemia model to show that subclonal de novo activating mutations drive clonal evolution in acut
Externí odkaz:
https://doaj.org/article/90c8b9707fb44780aabe13e7a04984b5
Autor:
Louise Ahlgren, Mattias Pilheden, Helena Sturesson, Varsha Singh, Qirui Zhang, Anders Castor, Cornelis Jan Pronk, Gisela Barbany, Katja Pokrovskaja Tamm, Linda Fogelstrand, Michael P Walsh, Guangchun Song, Jinghui Zhang, Jing Ma, Anna Hagstroem-Andersson
Publikováno v:
Blood. 140:9189-9190
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42680240df19725a9bff42e9805f60b5
https://doi.org/10.1182/blood-2022-165869
https://doi.org/10.1182/blood-2022-165869
Autor:
Anne Hultquist, Helena Sturesson, Jian Liu, Helena Ågerstam, Antoni Falqués-Costa, Axel Hyrenius-Wittsten, Mia Eriksson, Pauline Schneider, Marcus Järås, Mattias Pilheden, Cristian Garcia-Ruiz, Ronald W. Stam, Priscilla Wander, Henrik Lilljebjörn, Anna Hagström-Andersson
Publikováno v:
Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::661ee9a0257c93ceeaccaaa0d205e6e8
https://doi.org/10.1038/s41375-019-0465-1
https://doi.org/10.1038/s41375-019-0465-1
Autor:
Jing Ma, Axel Hyrenius-Wittsten, Helena Sturesson, Pankaj Gupta, Michael P. Walsh, Karin Lindkvist-Petersson, Jenny Hansson, Stephanie Nance, Anne Hultquist, Tanja A. Gruber, Anna Hagström-Andersson, Marcus Järås, Mattias Pilheden, Guangchun Song, Ramprasad Ramakrishan, Lars Rönnstrand, James R. Downing, Jinghui Zhang, Cristian Garcia-Ruiz, Julhash U. Kazi, Jian Liu, Kajsa Paulsson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
BASE-Bielefeld Academic Search Engine
Nature Communications
BASE-Bielefeld Academic Search Engine
Nature Communications
Activating signaling mutations are common in acute leukemia with KMT2A (previously MLL) rearrangements (KMT2A-R). These mutations are often subclonal and their biological impact remains unclear. Using a retroviral acute myeloid mouse leukemia model,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6a7e02305be98f74184dd491921b9a7
http://link.springer.com/article/10.1038/s41467-018-04180-1
http://link.springer.com/article/10.1038/s41467-018-04180-1
Autor:
Jing Ma, Ullrika Norén-Nyström, Michael P. Walsh, Helena Sturesson, Guangchun Song, Hanne Vibeke Marquart, Olli Lohi, Ton Falqués, Birgitte Lausen, Jinghui Zhang, Louise Ahlgren, Gisela Barbany, Cornelis J.H. Pronk, Katja Pokrovskaja Tamm, Anders Castor, Linda Fogelstrand, Mattias Pilheden, Anna Hagstroem-Andersson, James R. Downing, Axel Hyrenius Wittsten
Publikováno v:
Blood. 138:3479-3479
Genetic rearrangements involving the KMT2A gene (KMT2A-R) are seen in around 10% of acute leukemia overall. KMT2A-R occurs in all ages and usually correlates with high-risk clinical features, in particular in infants aged 0-12 months of age with acut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a25596cbed922d2e0bf517f6c04b3269
https://doi.org/10.1182/blood-2021-152082
https://doi.org/10.1182/blood-2021-152082
Autor:
Anna Hagstroem-Andersson, Mattias Pilheden, Lars Rönnstrand, Louise Ahlgren, Axel Hyrenius Wittsten, Ton Falqués, Julhash U. Kazi, Helena Sturesson, Qirui Zhang
Publikováno v:
Blood. 138:3354-3354
Our understanding of how individual mutations, whether present in all or just a fraction of the leukemia cells, affect cellular responses to therapy is limited. Leukemia mouse models provide a unique possibility to explore how therapy affects the evo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e711a1c4abb442119dbeddf2bdc0e16
https://doi.org/10.1182/blood-2021-144760
https://doi.org/10.1182/blood-2021-144760
Autor:
Henrik Lilljebjörn, Helena Sturesson, Stefan Scheding, Anna Andersson, Mats Ehinger, Mahtab Bidgoli, Tord Jonson, Axel Hyrenius-Wittsten
Publikováno v:
Genes, Chromosomes and Cancer. 55:847-854
Myelodysplastic/myeloproliferative neoplasms, unclassifiable (MDS/MPN-U) are rare genetically heterogeneous hematologic diseases associated with older age and a poor prognosis. If the disease progresses into acute myeloid leukemia (AML), it is often
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00aab817b5e7e014e52056f52facc207
https://doi.org/10.1002/gcc.22384
https://doi.org/10.1002/gcc.22384