Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Helena Sim"'
Autor:
Kevin C Knower, Sabine Kelly, Louisa M Ludbrook, Stefan Bagheri-Fam, Helena Sim, Pascal Bernard, Ryohei Sekido, Robin Lovell-Badge, Vincent R Harley
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17751 (2011)
BackgroundIn human embryogenesis, loss of SRY (sex determining region on Y), SOX9 (SRY-related HMG box 9) or SF1 (steroidogenic factor 1) function causes disorders of sex development (DSD). A defining event of vertebrate sex determination is male-spe
Externí odkaz:
https://doaj.org/article/bea90a38f7f8408cb1c98344a5605be2
Publikováno v:
Revista Latinoamericana en Ciencias Sociales, Niñez y Juventud, Vol 19, Iss 3, Pp 189-211 (2021)
Revista Latinoamericana de Ciencias Sociales, Niñez y Juventud, Volume: 19, Issue: 3, Pages: 189-211, Published: 07 DEC 2021
Revista Latinoamericana de Ciencias Sociales, Niñez y Juventud, Volume: 19, Issue: 3, Pages: 189-211, Published: 07 DEC 2021
Resumo (analítico) Este artículo es derivado de una investigación más amplia enfocada en cuatro colectivos de jóvenes inmigrantes en la ciudad de São Paulo y sus acciones político-culturales en la metrópoli. Basado en metodologías cualitativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca92f8913c461930e8cfaffd3fe542f
https://doi.org/10.11600/rlcsnj.19.3.4220
https://doi.org/10.11600/rlcsnj.19.3.4220
Autor:
Pablo Ramon Fruett da Costa, Cleonir Aparecida Salvario, Anderson José Manoel de Campos, Helena Simpson Laguardia, Frederico Lisita Costa, Antonio Moraes Farias Neto, Anderson José Lemos de Medeiros, Daniele Buitrago de Souza, Bruno Francesco Procat da Costa, Tiemi Fukushima Neves
Publikováno v:
Scientific Electronic Archives, Vol 16, Iss 12 (2023)
Resumo. A doença de Huntington (DH) é uma patologia neurodegenerativa que cursa com perdas motoras associadas a uma síndrome demencial de grande morbidade, cuja incidência aumenta com a idade. Não há cura, sendo as opções terapêuticas voltad
Externí odkaz:
https://doaj.org/article/e8fe8a2a18504768bc9cba6cfded9516
Autor:
Helena Simeunovic, Martina Dickenmann, Mitja Nabergoj, Helen Baldomero, Stavroula Masouridi‐Levrat, Gayathri Nair, Urs Schanz, Jacob Passweg, Alicia Rovo, Yves Chalandon, Ekaterina Rebmann
Publikováno v:
eJHaem, Vol 4, Iss 1, Pp 262-265 (2023)
Abstract Despite the high cure rate with initial therapy, approximately 10% of Hodgkin lymphoma (HL) patients are refractory to initial treatment, and up to 30% of patients will relapse after achieving initial complete remission. Despite promising in
Externí odkaz:
https://doaj.org/article/ca34f888599049ba8011b94a18ef2ad3
Autor:
Daniel Peter Czech, Helena Sim, Peter Koopman, Andrew H. Sinclair, Vincent R. Harley, Janelle Ryan, Pascal Bernard
Publikováno v:
Endocrinology. 153:901-912
Genome analysis of patients with disorders of sex development, and gain- and loss-of-function studies in mice indicate that gonadal development is regulated by opposing signals. In females, the Wnt/β-catenin canonical pathway blocks testicular diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36dad1de9d619fcf48f00865b818946a
https://doi.org/10.1210/en.2011-1347
https://doi.org/10.1210/en.2011-1347
Autor:
Daniel Peter Czech, Stefan Bagheri-Fam, Andrew H. Sinclair, Francis Poulet, Peter Koopman, Brigitte Boizet-Bonhoure, Vincent R. Harley, Anthony Argentaro, Helena Sim
Publikováno v:
Journal of Developmental Origins of Health and Disease. 2:S35-S150
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ba9bd9647905f9673b8d945f564b411
https://doi.org/10.1017/s2040174411000481
https://doi.org/10.1017/s2040174411000481
Autor:
Irumini Uthpala Anushini Jayakody, Stefan Bagheri-Fam, Vincent R. Harley, Helena Sim, Pascal Bernard, Makoto Mark Taketo, Gerd Scherer
Publikováno v:
Developmental Biology. 314(1):71-83
In mammals, sex is determined in the bipotential embryonic gonad by a balanced network of gene actions which when altered causes disorders of sexual development (DSD, formerly known as intersex). In the XY gonad, presumptive Sertoli cells begin to di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973b0601c8ce78be33ef66e5bf57feae
Autor:
Paul E. Micevych, Sabine Kelly, Eric Vilain, Pierre-Olivier Fernagut, Charleston W. K. Chiang, Kenneth H. Albrecht, Kevin Sinchak, Phoebe Dewing, Marie-Françoise Chesselet, Vincent R. Harley, Helena Sim
Publikováno v:
Current Biology. 16:415-420
SummaryThe central dogma of mammalian brain sexual differentiation has contended that sex steroids of gonadal origin organize the neural circuits of the developing brain [1]. Recent evidence has begun to challenge this idea and has suggested that, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1564c4ed8cd72efbb9fe51eeb3dbf5ec
https://doi.org/10.1016/j.cub.2006.01.017
https://doi.org/10.1016/j.cub.2006.01.017
Autor:
Scott Preiss, David A. Jans, Anthony Argentaro, Helena Sim, Vincent R. Harley, Andrew H. A. Clayton, Sabine Kelly
Publikováno v:
Journal of Biological Chemistry. 278:33839-33847
During mammalian sex determination, SOX9 is translocated into the nuclei of Sertoli cells within the developing XY gonad. The N-terminal nuclear localization signal (NLS) is contained within a SOX consensus calmodulin (CaM) binding region, thereby im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a17f5b074c47de4c97cee0c3ba76469
https://doi.org/10.1074/jbc.m302078200
https://doi.org/10.1074/jbc.m302078200
Autor:
Rodney J. Devenish, Helena Sim, George R. Stark, Lee H. Wong, Stephen John Ralph, Irene Hatzinisiriou, Moitreyee Chatterjee-Kishore
Publikováno v:
Journal of Biological Chemistry. 277:19408-19417
The transcription factor STAT1 plays a pivotal role in signal transduction of type I and II interferons (IFNs). STAT1 activation leads to changes in expression of key regulatory genes encoding caspases and cell cycle inhibitors. Deficient STAT1 expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::caab08ad7909097b2d61f09a2e14cd8d
https://doi.org/10.1074/jbc.m111302200
https://doi.org/10.1074/jbc.m111302200