Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Helena Paidassi"'
Autor:
Manon Venet, Margarida Sa Ribeiro, Elodie Décembre, Alicia Bellomo, Garima Joshi, Célia Nuovo, Marine Villard, David Cluet, Magali Perret, Rémi Pescamona, Helena Paidassi, Thierry Walzer, Omran Allatif, Alexandre Belot, Sophie Trouillet-Assant, Emiliano P. Ricci, Marlène Dreux
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Plasmacytoid DC (pDC) have been shown to secrete type I IFN and to be involved in controlling replication and spread of some viruses. Here the authors show that in severe SARS-CoV-2 infection pDC function is impaired leading to reduced type I IFN pro
Externí odkaz:
https://doaj.org/article/04fff4c178eb439c8dc6ad978ab2f441
Autor:
Anastasiia Gainullina, Denis A. Mogilenko, Li-Hao Huang, Helena Todorov, Vipin Narang, Ki-Wook Kim, Lim Sheau Yng, Andrew Kent, Baosen Jia, Kumba Seddu, Karen Krchma, Jun Wu, Karine Crozat, Elena Tomasello, Regine Dress, Peter See, Charlotte Scott, Sophie Gibbings, Geetika Bajpai, Jigar V. Desai, Barbara Maier, Sébastien This, Peter Wang, Stephanie Vargas Aguilar, Lucie Poupel, Sébastien Dussaud, Tyng-An Zhou, Veronique Angeli, J. Magarian Blander, Kyunghee Choi, Marc Dalod, Ivan Dzhagalov, Emmanuel L. Gautier, Claudia Jakubzick, Kory Lavine, Michail S. Lionakis, Helena Paidassi, Michael H. Sieweke, Florent Ginhoux, Martin Guilliams, Christophe Benoist, Miriam Merad, Gwendalyn J. Randolph, Alexey Sergushichev, Maxim N. Artyomov
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112046- (2023)
Summary: The diversity of mononuclear phagocyte (MNP) subpopulations across tissues is one of the key physiological characteristics of the immune system. Here, we focus on understanding the metabolic variability of MNPs through metabolic network anal
Externí odkaz:
https://doaj.org/article/8a6a390493e44f40a7321fccee2cd51c
Autor:
Alexandra Lainé, Ossama Labiad, Hector Hernandez-Vargas, Sébastien This, Amélien Sanlaville, Sophie Léon, Stéphane Dalle, Dean Sheppard, Mark A. Travis, Helena Paidassi, Julien C. Marie
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
TGFβ is secreted in an inactive form in the tumor microenvironment. Authors here show that although TGFβ is produced mainly by cancer cells, regulatory T cells are necessary for its activation via expression of the b8 chain of avb8 integrin. Thus,
Externí odkaz:
https://doaj.org/article/0099bf33b303405fa97900689fb2a35e
New perspectives on the regulation of germinal center reaction via αvβ8- mediated activation of TGFβ
Autor:
Sébastien This, Helena Paidassi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Transforming growth factor-β (TGFβ) is a long-known modulator of immune responses but has seemingly contradictory effects on B cells. Among cytokines, TGFβ has the particularity of being produced and secreted in a latent form and must be activated
Externí odkaz:
https://doaj.org/article/cca4e77639c0468b9981ad7c3183ddff
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0232307 (2020)
In the mammalian gut CD103+ve myeloid DCs are known to suppress inflammation threatened by luminal bacteria, but stimuli driving DC precursor maturation towards this beneficial phenotype are incompletely understood. We isolated CD11+ve DCs from mesen
Externí odkaz:
https://doaj.org/article/97d75229ee644dadb10d1fbca164e204
Autor:
Brian Webster, Scott W Werneke, Biljana Zafirova, Sébastien This, Séverin Coléon, Elodie Décembre, Helena Paidassi, Isabelle Bouvier, Pierre-Emmanuel Joubert, Darragh Duffy, Thierry Walzer, Matthew L Albert, Marlène Dreux
Publikováno v:
eLife, Vol 7 (2018)
Type I interferon (IFN-I) responses are critical for the control of RNA virus infections, however, many viruses, including Dengue (DENV) and Chikungunya (CHIKV) virus, do not directly activate plasmacytoid dendritic cells (pDCs), robust IFN-I produci
Externí odkaz:
https://doaj.org/article/4bd2a31ba81d48acb743048b6e88ee66
Autor:
Ranit Kedmi, Tariq A. Najar, Kailin R. Mesa, Allyssa Grayson, Lina Kroehling, Yuhan Hao, Stephanie Hao, Maria Pokrovskii, Mo Xu, Jhimmy Talbot, Jiaxi Wang, Joe Germino, Caleb A. Lareau, Ansuman T. Satpathy, Mark S. Anderson, Terri M. Laufer, Iannis Aifantis, Juliet M. Bartleson, Paul M. Allen, Helena Paidassi, James M. Gardner, Marlon Stoeckius, Dan R. Littman
Publikováno v:
Nature, vol 610, iss 7933
Nature
Nature, 2022, 610 (7933), pp.737-743. ⟨10.1038/s41586-022-05089-y⟩
Nature
Nature, 2022, 610 (7933), pp.737-743. ⟨10.1038/s41586-022-05089-y⟩
The mutualistic relationship of gut-resident microbiota and the host immune system promotes homeostasis that ensures maintenance of the microbial community and of a largely non-aggressive immune cell compartment1,2. The consequences of disturbing thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a84cab211530b906d38b48d797acdf56
https://escholarship.org/uc/item/4zh799vz
https://escholarship.org/uc/item/4zh799vz
Autor:
Xavier Charmetant, Chien-Chia Chen, Sarah Hamada, David Goncalves, Carole Saison, Maud Rabeyrin, Marion Rabant, Jean-Paul Duong van Huyen, Alice Koenig, Virginie Mathias, Thomas Barba, Florence Lacaille, Jérôme le Pavec, Olivier Brugière, Jean-Luc Taupin, Lara Chalabreysse, Jean-François Mornex, Lionel Couzi, Stéphanie Graff-Dubois, Raphaël Jeger-Madiot, Alexy Tran-Dinh, Pierre Mordant, Helena Paidassi, Thierry Defrance, Emmanuel Morelon, Lionel Badet, Antonino Nicoletti, Valérie Dubois, Olivier Thaunat
Publikováno v:
Science translational medicine. 14(663)
The generation of antibodies against donor-specific major histocompatibility complex (MHC) antigens, a type of donor-specific antibodies (DSAs), after transplantation requires that recipient’s allospecific B cells receive help from T cells. The cur
Autor:
Ranit Kedmi, Tariq Najar, Kailin R. Mesa, Allyssa Grayson, Lina Kroehling, Yuhan Hao, Stephanie Hao, Maria Pokrovskii, Mo Xu, Jhimmy Talbot, Jiaxi Wang, Joe Germino, Caleb A. Lareau, Ansuman T. Satpathy, Mark S. Anderson, Terri M. Laufer, Iannis Aifantis, Juliet M. Bartleson, Paul M. Allen, Helena Paidassi, James M. Gardner, Marlon Stoeckius, Dan R. Littman
The mutualistic relationship of gut-resident microbiota and cells of the host immune system promotes homeostasis that ensures maintenance of the microbial community and of a poised, but largely non-aggressive, immune cell compartment1, 2. Consequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1995e5ee2a948792ddd99cb492a540c6
https://doi.org/10.1101/2021.11.19.469318
https://doi.org/10.1101/2021.11.19.469318
Autor:
Remi Pescamona, Elodie Decembre, Thierry Walzer, Manon Venet, Alicia Bellomo, Alexandre Belot, Emiliano P. Ricci, Marine Villard, Magali Perret, Sophie Trouillet-Assant, Garima Joshi, Helena Paidassi, Omran Allatif, David Cluet, Margarida Sa Ribeiro, Marlène Dreux
Type I and III interferons (IFN-I/λ) are key antiviral mediators against SARS-CoV-2 infection. Here, we demonstrate that plasmacytoid dendritic cells (pDCs) are the predominant IFN-I/λ source following their sensing of SARS-CoV-2-infected cells. Me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63853f685a88b8d7eef68a916bea0810
https://doi.org/10.1101/2021.09.01.21262969
https://doi.org/10.1101/2021.09.01.21262969