Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Helena Païdassi"'
Autor:
Manon Venet, Margarida Sa Ribeiro, Elodie Décembre, Alicia Bellomo, Garima Joshi, Célia Nuovo, Marine Villard, David Cluet, Magali Perret, Rémi Pescamona, Helena Paidassi, Thierry Walzer, Omran Allatif, Alexandre Belot, Sophie Trouillet-Assant, Emiliano P. Ricci, Marlène Dreux
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Plasmacytoid DC (pDC) have been shown to secrete type I IFN and to be involved in controlling replication and spread of some viruses. Here the authors show that in severe SARS-CoV-2 infection pDC function is impaired leading to reduced type I IFN pro
Externí odkaz:
https://doaj.org/article/04fff4c178eb439c8dc6ad978ab2f441
Autor:
Anastasiia Gainullina, Denis A. Mogilenko, Li-Hao Huang, Helena Todorov, Vipin Narang, Ki-Wook Kim, Lim Sheau Yng, Andrew Kent, Baosen Jia, Kumba Seddu, Karen Krchma, Jun Wu, Karine Crozat, Elena Tomasello, Regine Dress, Peter See, Charlotte Scott, Sophie Gibbings, Geetika Bajpai, Jigar V. Desai, Barbara Maier, Sébastien This, Peter Wang, Stephanie Vargas Aguilar, Lucie Poupel, Sébastien Dussaud, Tyng-An Zhou, Veronique Angeli, J. Magarian Blander, Kyunghee Choi, Marc Dalod, Ivan Dzhagalov, Emmanuel L. Gautier, Claudia Jakubzick, Kory Lavine, Michail S. Lionakis, Helena Paidassi, Michael H. Sieweke, Florent Ginhoux, Martin Guilliams, Christophe Benoist, Miriam Merad, Gwendalyn J. Randolph, Alexey Sergushichev, Maxim N. Artyomov
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112046- (2023)
Summary: The diversity of mononuclear phagocyte (MNP) subpopulations across tissues is one of the key physiological characteristics of the immune system. Here, we focus on understanding the metabolic variability of MNPs through metabolic network anal
Externí odkaz:
https://doaj.org/article/8a6a390493e44f40a7321fccee2cd51c
New perspectives on the regulation of germinal center reaction via αvβ8- mediated activation of TGFβ
Autor:
Sébastien This, Helena Paidassi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Transforming growth factor-β (TGFβ) is a long-known modulator of immune responses but has seemingly contradictory effects on B cells. Among cytokines, TGFβ has the particularity of being produced and secreted in a latent form and must be activated
Externí odkaz:
https://doaj.org/article/cca4e77639c0468b9981ad7c3183ddff
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0232307 (2020)
In the mammalian gut CD103+ve myeloid DCs are known to suppress inflammation threatened by luminal bacteria, but stimuli driving DC precursor maturation towards this beneficial phenotype are incompletely understood. We isolated CD11+ve DCs from mesen
Externí odkaz:
https://doaj.org/article/97d75229ee644dadb10d1fbca164e204
Autor:
Brian Webster, Scott W Werneke, Biljana Zafirova, Sébastien This, Séverin Coléon, Elodie Décembre, Helena Paidassi, Isabelle Bouvier, Pierre-Emmanuel Joubert, Darragh Duffy, Thierry Walzer, Matthew L Albert, Marlène Dreux
Publikováno v:
eLife, Vol 7 (2018)
Type I interferon (IFN-I) responses are critical for the control of RNA virus infections, however, many viruses, including Dengue (DENV) and Chikungunya (CHIKV) virus, do not directly activate plasmacytoid dendritic cells (pDCs), robust IFN-I produci
Externí odkaz:
https://doaj.org/article/4bd2a31ba81d48acb743048b6e88ee66
Autor:
Anne Chouquet, Helena Païdassi, Wai Li Ling, Philippe Frachet, Gunnar Houen, Gérard J Arlaud, Christine Gaboriaud
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17886 (2011)
In the endoplasmic reticulum, calreticulin acts as a chaperone and a Ca(2+)-signalling protein. At the cell surface, it mediates numerous important biological effects. The crystal structure of the human calreticulin globular domain was solved at 1.55
Externí odkaz:
https://doaj.org/article/eaade0fab6c445af9f24313a60756608
Autor:
Alexandra Lainé, Ossama Labiad, Hector Hernandez-Vargas, Sébastien This, Amélien Sanlaville, Sophie Léon, Stéphane Dalle, Dean Sheppard, Mark A. Travis, Helena Paidassi, Julien C. Marie
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
TGFβ is secreted in an inactive form in the tumor microenvironment. Authors here show that although TGFβ is produced mainly by cancer cells, regulatory T cells are necessary for its activation via expression of the b8 chain of avb8 integrin. Thus,
Externí odkaz:
https://doaj.org/article/0099bf33b303405fa97900689fb2a35e
Publikováno v:
Annals of the New York Academy of Sciences. 1209
Defects in apoptotic cell clearance are thought to contribute to autoimmunity by failure to induce tolerance, coupled with accumulation of immunogenic material. However, little is known about the contribution of apoptosis to immune responses at mucos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::14b11be3c04d52bacec80d4f89d9b0fc
https://pubmed.ncbi.nlm.nih.gov/20958318
https://pubmed.ncbi.nlm.nih.gov/20958318
Autor:
Alice Koenig, Chien-Chia Chen, Antoine Marçais, Thomas Barba, Virginie Mathias, Antoine Sicard, Maud Rabeyrin, Maud Racapé, Jean-Paul Duong-Van-Huyen, Patrick Bruneval, Alexandre Loupy, Sébastien Dussurgey, Stéphanie Ducreux, Vannary Meas-Yedid, Jean-Christophe Olivo-Marin, Héléna Paidassi, Romain Guillemain, Jean-Luc Taupin, Jasper Callemeyn, Emmanuel Morelon, Antonino Nicoletti, Béatrice Charreau, Valérie Dubois, Maarten Naesens, Thierry Walzer, Thierry Defrance, Olivier Thaunat
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
‘Missing self’ is a mode of natural killer (NK) cell activation aimed to detect the lack of HLA-I molecules on infected or neoplastic cells. Here, the authors show that mismatch between donor HLA-I and cognate receptors on recipient NK cells medi
Externí odkaz:
https://doaj.org/article/6e54e790902d416d9bb11f07312515cd
Autor:
This, Sébastien
Publikováno v:
Immunology. Université de Lyon, 2020. English. ⟨NNT : 2020LYSEN011⟩
The ability of a host to generate an appropriate immune response is critical to provide protection against a particular pathogen and to provide long-lasting memory against future reinfection. However, this immune response must be tightly regulated to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a0e858a64bd9fe5d0ca430b4a183388e
https://theses.hal.science/tel-02613563/file/THIS_Sebastien_2020LYSEN011_These.pdf
https://theses.hal.science/tel-02613563/file/THIS_Sebastien_2020LYSEN011_These.pdf
