Computational Approaches to the Rational Design of Tubulin-Targeting Agents

Autor: Helena Pérez-Peña, Anne-Catherine Abel, Maxim Shevelev, Andrea E. Prota, Stefano Pieraccini, Dragos Horvath

Publikováno v: Biomolecules, Vol 13, Iss 2, p 285 (2023)

Microtubules are highly dynamic polymers of α,β-tubulin dimers which play an essential role in numerous cellular processes such as cell proliferation and intracellular transport, making them an attractive target for cancer and neurodegeneration res

Externí odkaz: https://doaj.org/article/d4f593ddf054481a8b5d47b16c72ba32

α-Synuclein: An All-Inclusive Trip Around its Structure, Influencing Factors and Applied Techniques

Autor: Nicolò Bisi, Lucia Feni, Kaliroi Peqini, Helena Pérez-Peña, Sandrine Ongeri, Stefano Pieraccini, Sara Pellegrino

Publikováno v: Frontiers in Chemistry, Vol 9 (2021)

Alpha-synuclein (αSyn) is a highly expressed and conserved protein, typically found in the presynaptic terminals of neurons. The misfolding and aggregation of αSyn into amyloid fibrils is a pathogenic hallmark of several neurodegenerative diseases

Externí odkaz: https://doaj.org/article/e04e2c7331384a49928be9456838938c

Rare pathogenic variants in WNK3 cause X-linked intellectual disability

Autor: Sébastien Küry, Jinwei Zhang, Thomas Besnard, Alfonso Caro-Llopis, Xue Zeng, Stephanie M. Robert, Sunday S. Josiah, Emre Kiziltug, Anne-Sophie Denommé-Pichon, Benjamin Cogné, Adam J. Kundishora, Le T. Hao, Hong Li, Roger E. Stevenson, Raymond J. Louie, Wallid Deb, Erin Torti, Virginie Vignard, Kirsty McWalter, F. Lucy Raymond, Farrah Rajabi, Emmanuelle Ranza, Detelina Grozeva, Stephanie A. Coury, Xavier Blanc, Elise Brischoux-Boucher, Boris Keren, Katrin Õunap, Karit Reinson, Pilvi Ilves, Ingrid M. Wentzensen, Eileen E. Barr, Solveig Heide Guihard, Perrine Charles, Eleanor G. Seaby, Kristin G. Monaghan, Marlène Rio, Yolande van Bever, Marjon van Slegtenhorst, Wendy K. Chung, Ashley Wilson, Delphine Quinquis, Flora Bréhéret, Kyle Retterer, Pierre Lindenbaum, Emmanuel Scalais, Lindsay Rhodes, Katrien Stouffs, Elaine M. Pereira, Sara M. Berger, Sarah S. Milla, Ankita B. Jaykumar, Melanie H. Cobb, Shreyas Panchagnula, Phan Q. Duy, Marie Vincent, Sandra Mercier, Brigitte Gilbert-Dussardier, Xavier Le Guillou, Séverine Audebert-Bellanger, Sylvie Odent, Sébastien Schmitt, Pierre Boisseau, Dominique Bonneau, Annick Toutain, Estelle Colin, Laurent Pasquier, Richard Redon, Arjan Bouman, Jill. A. Rosenfeld, Michael J. Friez, Helena Pérez-Peña, Syed Raza Akhtar Rizvi, Shozeb Haider, Stylianos E. Antonarakis, Charles E. Schwartz, Francisco Martínez, Stéphane Bézieau, Kristopher T. Kahle, Bertrand Isidor

Publikováno v: Genetics in Medicine, 24(9), 1941-1951. Lippincott Williams & Wilkins
GENETICS IN MEDICINE
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Genetics in Medicine
Genetics in Medicine, 2022, 24 (9), pp.1941-1951. ⟨10.1016/j.gim.2022.05.009⟩

PURPOSE: WNK3 kinase (PRKWNK3) has been implicated in the development and function of the brain via its regulation of the cation-chloride cotransporters, but the role of WNK3 in human development is unknown. METHOD: We ascertained exome or genome seq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711e752a43d1442b0a91b2645fc1747e
https://doi.org/10.1016/j.gim.2022.05.009

Front Cover: Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics (Chem. Eur. J. 5/2023)

Autor: Zlata Boiarska, Helena Pérez‐Peña, Anne‐Catherine Abel, Paola Marzullo, Beatriz Álvarez‐Bernad, Francesca Bonato, Benedetta Santini, Dragos Horvath, Daniel Lucena‐Agell, Francesca Vasile, Maurizio Sironi, J. Fernando Díaz, Andrea E. Prota, Stefano Pieraccini, Daniele Passarella

Publikováno v: Chemistry – A European Journal. 29

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62151d7f1737274c155ebde216c61902
https://doi.org/10.1002/chem.202300067

Maytansinol derivatives: side reactions as a chance for new tubulin binders

Autor: Paola Marzullo, Maurizio Sironi, Daniel Lucena-Agell, J. Fernando Díaz, Daniele Passarella, Helena Pérez-Peña, Zlata Boiarska, Stefano Pieraccini, Beatriz Álvarez-Bernad, Anne-Catherine Abel, Karl-Heinz Altmann, Andrea E. Prota, Francesca Vasile

Publikováno v: Chemistry – A European Journal
Digital.CSIC. Repositorio Institucional del CSIC
instname
Chemistry-A European Journal, 28 (2)

Maytansinol is a valuable precursor for the preparation of maytansine derivatives (known as maytansinoids). Inspired by the intriguing structure of the macrocycle and the success in targeted cancer therapy of the derivatives, we explored the maytansi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3462138c4725ef6c10a3c34703000338
http://hdl.handle.net/10261/257058