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Publikováno v:
Molecular Endocrinology. 5:897-904
In the mouse insulin is first detected on embryonic day 12 (e12) in a subpopulation of the cells that on e10 start to produce glucagon. During the continued embryonic development, the number of cells that coexpress the two hormones is gradually decre
Publikováno v:
Scopus-Elsevier
THE activity of the rat insulin I gene enhancer is mainly dependent on two cis-acting protein-binding domains1–3. Here we report the isolation of a complementary DNA encoding a protein, Isl-1, that binds to one of these domains. Isl-1 contains a ho
Publikováno v:
Lakartidningen. 103(13)
Publikováno v:
Scopus-Elsevier
The selective transcription of the Rat insulin 1 gene is mainly dependent on a beta-cell-specific enhancer element located in the 5' flanking DNA. In analogy to many other viral and cellular enhancers, the insulin enhancer has been shown to be of a m
Autor:
Helena Ohlsson, Thomas Edlund
Publikováno v:
Cell. 45(1)
Insulin 5′-flanking DNA contains two elements controlling cell-specific expression, one a cell-specific enhancer. We show that factors in nuclear extracts derived from an insulin-secreting cell line interact with three distinct regions within the i