Urinary Biomarkers and Their Potential for the Non-Invasive Detection of Endometrial Cancer

Autor: Kelechi Njoku, Davide Chiasserini, Eleanor R. Jones, Chloe E. Barr, Helena O’Flynn, Anthony D. Whetton, Emma J. Crosbie

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

Endometrial cancer is the most common malignancy of the female genital tract and its incidence is rising in parallel with the mounting prevalence of obesity. Early diagnosis has great potential to improve outcomes as treatment can be curative, especi

Externí odkaz: https://doaj.org/article/f1ec8aa1c6de45e39e3b3e2142ef9c2c

2022-RA-604-ESGO Urine and vaginal cytology detects endometrial cancer in women with postmenopausal bleeding

Autor: Eleanor Jones, Nadira Narine, Helena O’Flynn, Chloe Barr, Kelechi Njoku, Suzanne Carter, Lisa Cornwall, Sylvia Vinay, Catherine Fullwood, David Shelton, Durgesh Rana, Emma Crosbie

Publikováno v: Diagnostics.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f7c461f11a0bd2a2d2a0c784b1e089c
https://doi.org/10.1136/ijgc-2022-esgo.153

Synchronous uterine and bladder cancers detected in urine and vaginal samples by cytology

Autor: Neil A J Ryan, Helena O'Flynn, Nadira Narine, Dina Awad, Durgesh Rana, David Shelton, Emma J Crosbie, Eleanor R Jones

Publikováno v: Narine, N, Rana, D, Shelton, D, Awad, D, O'Flynn, H, Jones, E R, Ryan, N & Crosbie, E 2022, ' Synchronous uterine and bladder cancers detected in urine and vaginal samples by cytology ', Diagnostic Cytopathology . https://doi.org/10.1002/dc.24906

Novel diagnostics for uterine cancer are urgently needed to reduce the burden of invasive testing for the majority of healthy women with postmenopausal bleeding. We have previously shown that uterine cancer cells can be detected by cytology in urine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::969a3e471fb478e03fc48bf223d45e0c
https://pubmed.ncbi.nlm.nih.gov/34783454

Cytology for the diagnosis of endometrial cancer in symptomatic women

Autor: Helena O'Flynn, Emma J Crosbie, Eleanor K. Jones, Nadira Narine, Fiona M Walter, Tanya Walsh, Kelechi Njoku, Durgesh Rana, Neal C Ramchander, Vaishali Patel, David Shelton

Publikováno v: O'Flynn, H, Jones, E, Njoku, K, Rana, D, Shelton, D, Narine, N, Ramchander, N C, Patel, V, Walter, F M, Walsh, T & Crosbie, E J 2021, ' Cytology for the diagnosis of endometrial cancer in symptomatic women ', Cochrane Database of Systematic Reviews, vol. 2021, no. 5, CD014560 . https://doi.org/10.1002/14651858.CD014560
Cochrane Database Syst Rev

Objectives: This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows:. To assess the diagnostic accuracy of cytology for endometrial cancer detection in symptomatic women compared to histological diagnosis. Where a partici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5140dfa32d4f3954fb663bd7e5c0ba
https://research.manchester.ac.uk/en/publications/af8e9b9a-9de1-4bb6-99fa-108d5efa4ce9

Diagnostic accuracy of cytology for the detection of endometrial cancer in urine and vaginal samples

Autor: Nadira Narine, Helena O'Flynn, Emma J Crosbie, Neil A J Ryan, Durgesh Rana, David Shelton

Publikováno v: O'Flynn, H, Ryan, N, Narine, N, Shelton, D, Rana, D & Crosbie, E 2021, ' Diagnostic accuracy of cytology for the detection of endometrial cancer in urine and vaginal samples ', Nature Communications, vol. 12, 952 . https://doi.org/10.1038/s41467-021-21257-6
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Nature Communications

Postmenopausal bleeding triggers urgent investigation by sequential invasive tests that are avoidable for the 90–95% of women who do not have endometrial cancer. A simple, non-invasive tool that accurately identifies cancer and safely reassures hea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba8d5773a19c22f0a84c4a391d910a9
https://www.nature.com/articles/s41467-021-21257-6