Microdose lithium improves behavioral deficits and modulates molecular mechanisms of memory formation in female SAMP-8, a mouse model of accelerated aging.

Autor: Arthur Antonio Ruiz Pereira, Alessandra Macedo Pinto, Helena Nascimento Malerba, Mariana Toricelli, Hudson Sousa Buck, Tania Araujo Viel

Publikováno v: PLoS ONE, Vol 19, Iss 4, p e0299534 (2024)

Alzheimer's disease (AD) is the most common neuronal disorder that leads to the development of dementia. Until nowadays, some therapies may alleviate the symptoms, but there is no pharmacological treatment. Microdosing lithium has been used to modify

Externí odkaz: https://doaj.org/article/914a6cbb3afd4915a63a6d01ba827472

Combined Neuroprotective Strategies Blocked Neurodegeneration and Improved Brain Function in Senescence-Accelerated Mice

Autor: Helena Nascimento Malerba, Arthur Antonio Ruiz Pereira, Marcela Favoretto Pierrobon, Guilherme Souza Abrao, Mariana Toricelli, Eliana Hiromi Akamine, Hudson Sousa Buck, Tania Araujo Viel

Publikováno v: Frontiers in Aging Neuroscience, Vol 13 (2021)

Increase in the quality of life, combined with drug strategies, has been studied as possibilities for improving memory and delaying the onset of neurodegenerative diseases. A previous study published by the group of the authors has shown that microdo

Externí odkaz: https://doaj.org/article/95b114f5a3b149c986ca3ca7ea924f57

Kinin B2 Receptor Activation Prevents the Evolution of Alzheimer’s Disease Pathological Characteristics in a Transgenic Mouse Model

Autor: Marielza Andrade Nunes, Mariana Toricelli, Natalia Mendes Schöwe, Helena Nascimento Malerba, Karis Ester Dong-Creste, Daniela Moura Azevedo Tuma Farah, Katia De Angelis, Maria Claudia Irigoyen, Fernand Gobeil, Tânia Araujo Viel, Hudson Sousa Buck

Publikováno v: Pharmaceuticals, Vol 13, Iss 10, p 288 (2020)

Background: Alzheimer’s disease is mainly characterized by remarkable neurodegeneration in brain areas related to memory formation. This progressive neurodegeneration causes cognitive impairment, changes in behavior, functional disability, and even

Externí odkaz: https://doaj.org/article/f5dbf82f39b44dd68b31393f01a36b62

Mechanisms of neuroplasticity and brain degeneration: strategies for protection during the aging process

Autor: Guilherme de Souza Abrao, Arthur Antonio Ruiz Pereira, Hudson Sousa Buck, Mariana Toricelli, Julia Maia, Tania Araujo Viel, Helena Nascimento Malerba

Publikováno v: Neural Regeneration Research
Neural Regeneration Research, Vol 16, Iss 1, Pp 58-67 (2021)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Aging is a dynamic and progressive process that begins at conception and continues until death. This process leads to a decrease in homeostasis and morphological, biochemical and psychological changes, increasing the individual’s vulnerability to v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93418e2c28067854cb74bdbd32c17398
https://doi.org/10.4103/1673-5374.286952

Microdose lithium improves behavioral deficits and modulates molecular mechanisms of memory formation in female SAMP-8, a mouse model of accelerated aging.

Autor: Pereira, Arthur Antonio Ruiz^1,2 (AUTHOR), Pinto, Alessandra Macedo³ (AUTHOR), Malerba, Helena Nascimento^1,2 (AUTHOR), Toricelli, Mariana² (AUTHOR), Buck, Hudson Sousa^2,4 (AUTHOR), Viel, Tania Araujo^1,2,3 (AUTHOR) taniaviel@usp.br

Publikováno v: PLoS ONE. 4/4/2024, Vol. 19 Issue 4, p1-20. 20p.