Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Helena Meng-Lund"'
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 160
The typical excipients used as bulking agents and lyoprotectants for freeze-drying are usually limited to only a few selected substances, such as sucrose and mannitol. Considering the sheer diversity amongst proteins, it is doubtful that this limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aeaccb7482e09d3b5cef5bbf8543562
https://pubmed.ncbi.nlm.nih.gov/33508435
https://pubmed.ncbi.nlm.nih.gov/33508435
Autor:
Bjarke Strom Larsen, Jeppe Skytte, Helena Meng-Lund, Anna J. Svagan, Holger Grohganz, Korbinian Löbmann
Publikováno v:
Pharmaceutical Development and Technology. 24:323-328
Freeze-drying of protein formulations is frequently used to maintain protein activity during storage. The freeze-drying process usually requires long primary drying times because the highest acceptable drying temperature to obtain acceptable products
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be08623235504e356749e5d577b482e
https://doi.org/10.1080/10837450.2018.1479866
https://doi.org/10.1080/10837450.2018.1479866
Autor:
Natascha Friis, Holger Grohganz, Marco van de Weert, Helena Meng-Lund, Jukka Rantanen, Antti Poso, Lene Jorgensen
Publikováno v:
International Journal of Pharmaceutics. 523:238-245
A quantitative structure-property relationship (QSPR) between protein stability and the physicochemical properties of excipients was investigated to enable a more rational choice of stabilizing excipients than prior knowledge. The thermal transition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a2129d7a09900ff78c77abee0754b3
https://doi.org/10.1016/j.ijpharm.2017.03.043
https://doi.org/10.1016/j.ijpharm.2017.03.043
Autor:
Lene Jorgensen, Jonatan Riis Christensen, Holger Grohganz, Helena Meng-Lund, Jari Pajander, Ossi Korhonen, Tuomo Laitinen, Antti Poso
Publikováno v:
European Journal of Pharmaceutical Sciences. 102:188-195
In recent years, the demand and interest for functionalized polymers have increased for drug delivery purposes. Because of the increased interest, methods that can be used to predict physical and chemical properties of polymers prior to synthesis wou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c735678101abb7b0e64e1c53511c3af
https://doi.org/10.1016/j.ejps.2017.03.013
https://doi.org/10.1016/j.ejps.2017.03.013
Autor:
Jukka Rantanen, Lene Jorgensen, Helena Meng-Lund, Holger Grohganz, Antti Poso, Tobias Palle Holm
Publikováno v:
International journal of pharmaceutics. 566
Commonly, a limited number of generally accepted bulking agents and lyoprotectants are used for freeze-drying; predominantly mannitol, glycine, sucrose and trehalose. The purpose of this study was to combine a theoretical approach using molecular des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5139c33b29a12dca653715cbecb0a37
https://pubmed.ncbi.nlm.nih.gov/31145963
https://pubmed.ncbi.nlm.nih.gov/31145963
Autor:
Helena Meng-Lund, Jukka Rantanen, Holger Grohganz, Tatu Pantsar, Katrine Tarp Jensen, Thomas Rades, Georgia Kasten, Antti Poso
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 119
Co-amorphous systems consisting of a drug and an amino acid have been investigated extensively for the enhancement of drug solubility and amorphous stability. The purpose of this study is to investigate which molecular descriptors are important for p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e73988b671d1ffa91bb79cf71f1142a
https://pubmed.ncbi.nlm.nih.gov/29649569
https://pubmed.ncbi.nlm.nih.gov/29649569