Iron-Catalysed Carbene Transfer to Isocyanides as a Platform for Heterocycle Synthesis

Autor: Thomas R. Roose, H. Daniel Preschel, Helena Mayo Tejedor, Jasper C. Roozee, Trevor A. Hamlin, Bert U. W. Maes, Eelco Ruijter, Romano V. A. Orru

Publikováno v: Chemistry: a European journal. Wiley-VCH Verlag
Chemistry-A European Journal, 29(9):e202203074. Wiley-VCH Verlag
Chemistry: a European journal
Roose, T R, Preschel, H D, Mayo Tejedor, H, Roozee, J C, Hamlin, T A, Maes, B U W, Ruijter, E & Orru, R V A 2023, ' Iron-Catalysed Carbene Transfer to Isocyanides as a Platform for Heterocycle Synthesis ', Chemistry-A European Journal, vol. 29, no. 9, e202203074 . https://doi.org/10.1002/chem.202203074

An iron-catalysed carbene transfer reaction of diazo compounds to isocyanides has been developed. The resulting ketenimines are trapped in situ with various bisnucleophiles to access a range of densely functionalized heterocycles (pyrimidinones, dihy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d578828a51daa1250d910a7c4c6ef4
https://doi.org/10.1002/chem.202203074