A novel luminescence-based β-arrestin recruitment assay for unmodified receptors

Autor: Jonathan A. Javitch, Wesley B. Asher, Jennifer Pham, Asuka Inoue, Maria Hauge Pedersen, Helena Mancebo

Publikováno v: The Journal of Biological Chemistry
Pedersen, M H, Pham, J, Mancebo, H, Inoue, A, Asher, W B & Javitch, J A 2021, ' A novel luminescence-based β-arrestin recruitment assay for unmodified receptors ', Journal of Biological Chemistry, vol. 296, 100503 . https://doi.org/10.1016/j.jbc.2021.100503

G protein-coupled receptors (GPCRs) signal through activation of G proteins and subsequent modulation of downstream effectors. More recently, signaling mediated by β-arrestin has also been implicated in important physiological functions. This has le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953cfc6071b8c13a92b3add8ed756a95
https://pubmed.ncbi.nlm.nih.gov/33684444

Homology Modeling of Ffa2 Identifies Novel Agonists that Potentiate Insulin Secretion

Autor: Annette Gilchrist, Stephanie R. Villa, Rama K. Mishra, Gary E. Schiltz, Medha Priyadarshini, Joseph L. Zapater, Helena Mancebo, Brian T. Layden

Publikováno v: Journal of Investigative Medicine. 65:1116-1124

Critical aspects of maintaining glucose homeostasis in the face of chronic insulin resistance and type 2 diabetes (T2D) are increased insulin secretion and adaptive expansion of beta cell mass. Nutrient and hormone sensing G protein-coupled receptors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5f1ca87542e9cb6bfc918d0ce427ba
https://doi.org/10.1136/jim-2017-000523

Loss of Free Fatty Acid Receptor 2 leads to impaired islet mass and beta cell survival

Autor: Medha Priyadarshini, Anthony R. Angueira, Maureen Gannon, Sarah A. Tersey, Miles Fuller, Bethany A. Carboneau, Tanya Bhardwaj, Annette Gilchrist, Raghavendra G. Mirmira, Rockann E. Mosser, Brian T. Layden, Michael R. Brodsky, Stephanie R. Villa, Helena Mancebo

Publikováno v: Scientific Reports

The regulation of pancreatic β cell mass is a critical factor to help maintain normoglycemia during insulin resistance. Nutrient-sensing G protein-coupled receptors (GPCR) contribute to aspects of β cell function, including regulation of β cell ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79be7984b7a2a6d9c2931b459896080
https://doi.org/10.1038/srep28159

Effects of LTB4 receptor antagonism on pulmonary inflammation in rodents and non-human primates

Autor: Anjula Pamidimukkala, Jian Ping Lou, Paul Gillespie, Rachid Hamid, Hyesun Oh, Thomas H. March, D Lavelle, Lisa C. F. Chao, Tina Molinaro, Matthew Blake Wright, Martin Brovarney, A. Robert Catala, John O’Neil, Agnieszka Kowalczyk, Louis M. Renzetti, Nader Fotouhi, Maureen Hargaden, John Satjawatcharaphong, Karen Pozzani, Xin Wei, Thomas Egan, Radhika Venkat, Ruben Marcano, Shahid Tannu, Karim Dabbagh, Helena Mancebo, Laura Singer, Martin Lamb, David J Moore, Jessica D. Ventre, Janet M. Benson, Ying L. Li, Jennifer Santiago, Ann F. Hoffman, Alexandra Hicks, Gary Cavallo, Jose M. Lora, Robert Alan Goodnow, Ueli Gubler, Romyr Dominique, Achyutharao Sidduri, Nadine Tare, Qi Qiao, Grazyna Kurylko

Publikováno v: Prostaglandinsother lipid mediators. 92(1-4)

Asthma, chronic obstructive pulmonary disease (COPD) and acute lung injury/acute respiratory distress syndrome (ALI/ARDS) are characterized by neutrophilic inflammation and elevated levels of leukotriene B4 (LTB4). However, the exact role of LTB4 pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a72bd708fcaa8a3eadcb8c1fcef6fbe
https://pubmed.ncbi.nlm.nih.gov/20214997