Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Helena M Kok"'
Autor:
Shuang Li, Christian G. M. van Dijk, Jan Meeldijk, Helena M. Kok, Isabelle Blommestein, Annick L. F. Verbakel, Marit Kotte, Roel Broekhuizen, Miangela M. Laclé, Roel Goldschmeding, Caroline Cheng, Niels Bovenschen
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Angiogenesis is crucial for normal development and homeostasis, but also plays a role in many diseases including cardiovascular diseases, autoimmune diseases, and cancer. Granzymes are serine proteases stored in the granules of cytotoxic cells, and h
Externí odkaz:
https://doaj.org/article/22af64ee4d7143799495f75859823f2c
Increased intra-articular granzyme M may trigger local IFN-λ1/IL-29 response in rheumatoid arthritis
Autor:
Liling Shan, Lucas L. van den Hoogen, Jan Meeldijk, Helena M. Kok, Lieneke H. Jongeneel, Marianne Boes, Mark H. Wenink, C. Erik Hack, Timothy R.D.J. Radstake, Joel A.G. van Roon, Niels Bovenschen
Publikováno v:
Clinical and Experimental Rheumatology. 38:220-226
Increased intra-articular granzyme M may trigger local IFN-λ1/IL-29 response in rheumatoid arthritis
Autor:
Liling, Shan, Lucas L, van den Hoogen, Jan, Meeldijk, Helena M, Kok, Lieneke H, Jongeneel, Marianne, Boes, Mark H, Wenink, C Erik, Hack, Timothy R D J, Radstake, Joel A G, van Roon, Niels, Bovenschen
Publikováno v:
Clinical and experimental rheumatology. 38(2)
Granzymes are serine proteases involved in eliminating tumour cells and virally infected cells. In addition, extracellular granzyme levels are elevated in inflammatory conditions, including several types of infection and autoimmune diseases, such as
Publikováno v:
Nature Reviews Nephrology. 10:700-711
Chronic kidney disease (CKD) is a major health and economic burden with a rising incidence. During progression of CKD, the sustained release of proinflammatory and profibrotic cytokines and growth factors leads to an excessive accumulation of extrace
Autor:
Rachel H, Church, Imran, Ali, Mitchel, Tate, Deborah, Lavin, Arjun, Krishnakumar, Helena M, Kok, Jose R, Hombrebueno, Philip D, Dunne, Victoria, Bingham, Roel, Goldschmeding, Finian, Martin, Derek P, Brazil
Publikováno v:
American Journal of Physiology-Renal Physiology
Gremlin1 (Grem1), an antagonist of bone morphogenetic proteins, plays a key role in embryogenesis. A highly specific temporospatial gradient of Grem1 and bone morphogenetic protein signaling is critical to normal lung, kidney, and limb development. G
Autor:
Niels Bovenschen, Annette C. Wensink, Jan Meeldijk, C. Erik Hack, Job Fermie, Helena M Kok, Christopher J. Froelich
Publikováno v:
Cell Death Discovery
Cell death discovery, 2(1). Nature Publishing Group
Cell death discovery, 2(1). Nature Publishing Group
Granzymes are serine proteases that, upon release from cytotoxic cells, induce apoptosis in tumor cells and virally infected cells. In addition, a role of granzymes in inflammation is emerging. Recently, we have demonstrated that extracellular granzy