Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Helena M Earl"'
Autor:
Christine A Parkinson, Davina Gale, Anna M Piskorz, Heather Biggs, Charlotte Hodgkin, Helen Addley, Sue Freeman, Penelope Moyle, Evis Sala, Karen Sayal, Karen Hosking, Ioannis Gounaris, Mercedes Jimenez-Linan, Helena M Earl, Wendi Qian, Nitzan Rosenfeld, James D Brenton
Publikováno v:
PLoS Medicine, Vol 13, Iss 12, p e1002198 (2016)
BackgroundCirculating tumour DNA (ctDNA) carrying tumour-specific sequence alterations may provide a minimally invasive means to dynamically assess tumour burden and response to treatment in cancer patients. Somatic TP53 mutations are a defining feat
Externí odkaz:
https://doaj.org/article/a390f131ca6d41f198c5c746342604e0
Autor:
Leila Dorling, Siddhartha Kar, Kyriaki Michailidou, Louise Hiller, Anne-Laure Vallier, Susan Ingle, Richard Hardy, Sarah J Bowden, Janet A Dunn, Chris Twelves, Christopher J Poole, Carlos Caldas, Helena M Earl, Paul D P Pharoah, Jean E Abraham
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158984 (2016)
Ninety-four common genetic variants are confirmed to be associated with breast cancer. This study tested the hypothesis that breast cancer susceptibility variants may also be associated with chemotherapy-induced toxicity through shared mechanistic pa
Externí odkaz:
https://doaj.org/article/cc44ad5767ef4dec85d725fa880c002a
Autor:
Roland F Schwarz, Charlotte K Y Ng, Susanna L Cooke, Scott Newman, Jillian Temple, Anna M Piskorz, Davina Gale, Karen Sayal, Muhammed Murtaza, Peter J Baldwin, Nitzan Rosenfeld, Helena M Earl, Evis Sala, Mercedes Jimenez-Linan, Christine A Parkinson, Florian Markowetz, James D Brenton
Publikováno v:
PLoS Medicine, Vol 12, Iss 2, p e1001789 (2015)
BackgroundThe major clinical challenge in the treatment of high-grade serous ovarian cancer (HGSOC) is the development of progressive resistance to platinum-based chemotherapy. The objective of this study was to determine whether intra-tumour genetic
Externí odkaz:
https://doaj.org/article/0a04b45ee3a2448488392ea351cd23be
Autor:
Surrin S. Deen, Frank Riemer, Mary A. McLean, Andrew B. Gill, Joshua D. Kaggie, James T. Grist, Robin Crawford, John Latimer, Peter Baldwin, Helena M. Earl, Christine A. Parkinson, Sarah A. Smith, Charlotte Hodgkin, Elizabeth Moore, Mercedes Jimenez-Linan, Cara R. Brodie, Helen C. Addley, Susan J. Freeman, Penelope L. Moyle, Evis Sala, Martin J. Graves, James D. Brenton, Ferdia A. Gallagher
Publikováno v:
European Journal of Radiology Open, Vol 6, Iss , Pp 156-162 (2019)
The aim of this study was to assess the feasibility of rapid sodium MRI (23Na-MRI) for the imaging of peritoneal cancer deposits in high grade serous ovarian cancer (HGSOC) and to evaluate the relationship of 23Na-MRI with tumour cellularity. 23Na-MR
Externí odkaz:
https://doaj.org/article/43b9f269f1f743b1a86653c4529bf6eb
Autor:
Robert Stein, Andreas Makris, Iain Macpherson, Luke Hughes-Davies, Andrea Marshall, Georgina Dotchin, David A. Cameron, Belinda E. Kiely, Caroline Wilson, Anne Armstrong, Helena M. Earl, Christopher J. Poole, Janice Tsang, Bjørn Naume, Daniel Rea, Hege Ohnstad, Peter S. Hall, Stuart A. McIntosh, Bethany Shinkins, Christopher McCabe, Adrienne Morgan, John MS Bartlett, Janet A. Dunn
Publikováno v:
Cancer Research. 83:OT3-32
Background: Multi-parameter tumor gene expression assays (MPAs) are used to estimate individual patient risk and guide chemotherapy use in hormone-sensitive, HER2-negative early breast cancer. The TAILORx trial supports MPA use in a node-negative pop
Autor:
Helena M. Earl, Paul P.D. Pharoah, Carlos Caldas, Christopher J. Poole, Janet A. Dunn, Sarah J. Bowden, Linda Jones, Russell Burns, Louise Hiller, Anne-Laure Vallier, Richard Hardy, Susan Ingle, Jonathan Tyrer, Leila Dorling, Qi Guo, Jean E. Abraham
Purpose: Associations between taxane-related sensory neuropathy (TRSN) and single-nucleotide polymorphisms (SNP) have previously been reported, but few have been replicated in large, independent validation studies. This study evaluates the associatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910ca8484e173bc19a9b74cffea65744
https://doi.org/10.1158/1078-0432.c.6522995
https://doi.org/10.1158/1078-0432.c.6522995
Autor:
Helena M. Earl, Paul P.D. Pharoah, Carlos Caldas, Christopher J. Poole, Janet A. Dunn, Sarah J. Bowden, Linda Jones, Russell Burns, Louise Hiller, Anne-Laure Vallier, Richard Hardy, Susan Ingle, Jonathan Tyrer, Leila Dorling, Qi Guo, Jean E. Abraham
PDF file - 237KB, Supplementary Table 1: Published Studies of Putative Functional SNPs Supplementary Table 2a: Drug Regimens and Doses of Taxanes by Study Supplementary Table 2b: Comparison of Toxicity grades/rates by recruiting trial in PGSNPS inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::508c9a46258ea6b32495d0b31edfa9e8
https://doi.org/10.1158/1078-0432.22455335
https://doi.org/10.1158/1078-0432.22455335
Autor:
Charlotte Elizabeth Coles, Benjamin O Anderson, David Cameron, Fatima Cardoso, Richard Horton, Felicia Marie Knaul, Miriam Mutebi, Naomi Lee, Jean E Abraham, Fabrice André, Carlos H Barrios, Judith M Bliss, Judy C Boughey, David A Cameron, Fatima V Cardoso, Lisa A Carey, Sanjoy Chatterjee, Charlotte E Coles, Jack Cuzick, Dorothy Du Plooy, Prudence A Francis, Julie R Gralow, Reshma Jagsi, Felicia M Knaul, Fei Ma, Ritse M Mann, Stuart A McIntosh, Shirley A Mertz, Funmi Olopade, Kelly-Anne Phillips, Philip M Poortmans, Tanja Spanic, Dingle Spence, Hilary Stobart, Fraser WF Symmans, Cynthia Villarreal-Garza, Cheng-Har Yip, Maya J Bienz, Lynsey M Drewett, Alex Fulton, Dharrnesha Inbah Rajah, Farasat Kazmi, Jeffrey Rubasingham, Mareike Thompson, Valentina Vargas, Hector Arreola, Raj A Badwe, Renzo JC Calderon Anyosa, Rajiv V Dave, Ama De-Graft Aikins, Helena M Earl, Beverley M Essue, Ruth B Etzioni, Sarah T Hawley, Xiaoxiao Jiang, Indraneel Mittra, Patricia I Moreno, Renu Sara Nargund, Cara Noble, Robert A Smith, Didier Verhoeven, Jiani N Wang, David A Watkins, Brian J Zikmund-Fisher
Publikováno v:
2022, ' The Lancet Breast Cancer Commission: tackling a global health, gender, and equity challenge ', The Lancet, vol. 399, no. 10330, pp. 1101-1103 . https://doi.org/10.1016/S0140-6736(22)00184-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc7ab9cd7b30765d97443eeccc25a718
https://www.pure.ed.ac.uk/ws/files/250245693/lancet_breast_cancer_commission_launch_comment_v12.pdf
https://www.pure.ed.ac.uk/ws/files/250245693/lancet_breast_cancer_commission_launch_comment_v12.pdf
Autor:
Johann Bauersachs, Petar M. Seferovic, Teresa López-Fernández, Ovidiu Chioncel, Ronald M. Witteles, Michael G. Fradley, Bonnie Ky, Daniel J. Lenihan, Thomas Thum, Dragana Milojkovic, Paaladinesh Thavendiranathan, Javid Moslehi, Michael J. Mauro, Frank Ruschitzka, Thomas M. Suter, John D. Groarke, Jutta Bergler-Klein, Charlotte Manisty, Li Ling Tan, Vincent Khoo, Ariane Vieira Scarlatelli Macedo, Radek Pudil, Ashutosh Wechelaker, Dimitrios Farmakis, Y N Belenkov, Susan Dent, Hugues de Lavallade, Chris Plummer, Susannah Stanway, Alain Cohen-Solal, Tomas G. Neilan, Alexander R. Lyon, Fortunato Ciardiello, Andrew J.S. Coats, M. Sol Andres, Daniela Cardinale, Hadi Skouri, David Wright, Ana Barac, Christoph Maack, Stuart D. Rosen, Christine Brezden-Masley, Zaza Iakobishvili, Robert F. Cornell, Markus S. Anker, Aaron L. Sverdlov, Helena M. Earl, Carlo G. Tocchetti, Ludhmila Abrahão Hajjar, Stephan von Haehling, Joerg Herrmann, Rudolf A. de Boer
Publikováno v:
European Journal of Heart Failure. 22:1945-1960
This position statement from the Heart Failure Association of the European Society of Cardiology Cardio-Oncology Study Group in collaboration with the International Cardio-Oncology Society presents practical, easy-to-use and evidence-based risk strat
Autor:
Timothy J. Perren, Rosemary Lord, Jane Hook, Ian A. McNeish, Christopher J. Poole, Jonathan A. Ledermann, Helena M. Earl, Sarah P. Blagden, Adrian Cook, Jae Weon Kim, Graham Dark, Andrew R Clamp, Marcia Hall, Dearbhaile M. O'Donnell, Richard Kaplan, Ian R. White, Lesley Howells, Andrew Dean, Elizabeth C. James
Publikováno v:
Lancet Oncol
The Lancet. Oncology
The Lancet. Oncology
Summary Background The ICON8 study reported no significant improvement in progression-free survival (a primary endpoint) with weekly chemotherapy compared with standard 3-weekly treatment among patients with epithelial ovarian cancer. All ICON8 patie