Výsledky vyhledávání - "Helena Janickova"

Akademický článek

Expression and function of nicotinic acetylcholine receptors in specific neuronal populations: Focus on striatal and prefrontal circuits

Autor: Alice Abbondanza, Anna Urushadze, Amanda Rosanna Alves-Barboza, Helena Janickova

Publikováno v: Pharmacological Research, Vol 204, Iss , Pp 107190- (2024)

Nicotinic acetylcholine receptors (nAChRs) are widely expressed in the central nervous system and play an important role in the control of neural functions including neuronal activity, transmitter release and synaptic plasticity. Although the common

Externí odkaz: https://doaj.org/article/4276eb489bf64cbab9d9a74a1993a2d4

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Cholinergic transmission from the basal forebrain modulates social memory in male mice

Autor: Marco A. M. Prado, Vania F. Prado, Monica S. Guzman, Helena Janickova, Mohammed A. Al-Onaizi, Ornela Kljakic, Kevin S. Chen

Publikováno v: European Journal of Neuroscience. 54:6075-6092

Disruptions in social behaviour are prevalent in many neuropsychiatric disorders such as schizophrenia, bipolar disorder and autism spectrum disorders. However, the underlying neurochemical regulation of social behaviour is still not well understood.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8138eaa895ce2fed3d3b1879b89ca6bb
https://doi.org/10.1111/ejn.15400

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AAV-mediated neuronal expression of a scFv antibody selective for Aβ oligomers protects synapses and rescues memory in Alzheimer models

Brain accumulation of soluble oligomers of the amyloid-β peptide (AβOs) has been implicated in synapse failure and memory impairment in Alzheimer’s disease. Here, we show that treatment with NUsc1, a single-chain variable fragment antibody (scFv)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c799d8404ca4fad532b4c7c4175c970
https://doi.org/10.1101/2022.06.10.495369

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Cholinergic dysfunction in the dorsal striatum promotes habit formation and maladaptive eating

Publikováno v: J Clin Invest

Dysregulation of habit formation has been recently proposed as pivotal to eating disorders. Here, we report that a subset of patients suffering from restrictive anorexia nervosa have enhanced habit formation compared with healthy controls. Habit form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f76fbba6de0f097adeb0a34c32fcfa7
https://doi.org/10.1172/jci138532

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Nicotinic Acetylcholine Receptors Expressed by Striatal Interneurons Inhibit Striatal Activity and Control Striatal-Dependent Behaviors

Autor: Alice Abbondanza, Irina Ribeiro Bas, Martin Modrak, Martin Capek, Jessica Minich, Alexandra Tyshkevich, Shahed Naser, Revan Rangotis, Pavel Houdek, Alena Sumova, Sylvie Dumas, Veronique Bernard, Helena Janickova

Publikováno v: Journal of Neuroscience
Journal of Neuroscience, 2022, 42 (13), pp.2786-2803. ⟨10.1523/JNEUROSCI.1627-21.2022⟩
J Neurosci

Acetylcholine is an important modulator of striatal activity, and it is vital to controlling striatal-dependent behaviors, including motor and cognitive functions. Despite this significance, the mechanisms determining how acetylcholine impacts striat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2fde05fee3412bffaa7253e2a9f4a4d
https://hal.science/hal-03633584/document

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Evaluating Sequential Response Learning in the Rodent Operant Touchscreen System

Autor: Trevor W. Robbins, Timothy J. Bussey, Marco A. M. Prado, Ornela Kljakic, Lisa M. Saksida, Helena Janickova, Vania F. Prado

Publikováno v: Brain and Mind Institute Researchers' Publications

Sequential and cue-directed response learning in rodents have been previously shown to depend on intact striatal signaling. In particular, these behaviors rely on striatal dopamine and acetylcholine release, with an impairment of sequential response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2640c06bd0a7b4920c13d09d91b26921
https://doi.org/10.1002/cpz1.268

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