Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Helena Hohtari"'
Autor:
Helena Hohtari, Niels Pallisgaard, Matti Kankainen, Pekka Ellonen, Oscar Brück, Timo Siitonen, Marjaana Säily, Marjatta Sinisalo, Marja Pyörälä, Maija Itälä-Remes, Perttu Koskenvesa, Erkki Elonen, Satu Mustjoki, Kimmo Porkka
Publikováno v:
Haematologica, Vol 107, Iss 8 (2022)
Externí odkaz:
https://doaj.org/article/5387630602a9470ab1aafc96dd4f32f5
Autor:
Helena Hohtari, Matti Kankainen, Shady Adnan-Awad, Bhagwan Yadav, Swapnil Potdar, Aleksandr Ianevski, Olli Dufva, Caroline Heckman, Veronika Sexl, Soili Kytölä, Satu Mustjoki, Kimmo Porkka
Publikováno v:
HemaSphere, Vol 6, Iss 3, p e701 (2022)
In adult patients, the treatment outcome of acute lymphoblastic leukemia (ALL) remains suboptimal. Here, we used an ex vivo drug testing platform and comprehensive molecular profiling to discover new drug candidates for B-ALL. We analyzed sensitivity
Externí odkaz:
https://doaj.org/article/8ef93768f7754e64a0bfcedd49b3938c
Autor:
Helena Hohtari, Matti Kankainen, Shady Adnan-Awad, Bhagwan Yadav, Swapnil Potdar, Aleksandr Ianevski, Olli Dufva, Caroline Heckman, Veronika Sexl, Soili Kytölä, Satu Mustjoki, Kimmo Porkka
In adult patients, the treatment outcome of acute lymphoblastic leukemia (ALL) remains suboptimal. Here, we used an ex vivo drug testing platform and comprehensive molecular profiling to discover new drug candidates for B-ALL. We analyzed sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc980f55245c83c6a73cbbbfeecb11d
http://hdl.handle.net/10138/343159
http://hdl.handle.net/10138/343159
Autor:
Helena Hohtari, Judith Leitner, Pekka Ellonen, Tero Aittokallio, Satu Mustjoki, Matti Korhonen, Khalid Saeed, Pilvi Maliniemi, Tiina Hannunen, Peter Steinberger, Jan Koski, Mikko Antti Ilmari Keränen, Aleksandr Ianevski, Petri Pölönen, Matti Kankainen, Olli Dufva, Jay Klievink
Publikováno v:
Blood. 135:597-609
Funding Information: The authors thank Laura Turunen, Jani Saarela, Katja Suomi, and Maria Nurmi of the High-Throughput Biomedicine Unit and the personnel of the Sequencing Laboratory at the Institute of Molecular Medicine Finland. The authors also t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20992c0de36ff892c0d02f601e3f99ba
https://doi.org/10.1182/blood.2019002121
https://doi.org/10.1182/blood.2019002121
Autor:
Matti Kankainen, Komal Kumar Javarappa, Soili Kytölä, Helena Hohtari, Satu Mustjoki, Swapnil Potdar, Shady Adnan-Awad, Kimmo Porkka, Caroline A. Heckman, Isabella Maria Mayer, Daehong Kim, Tania Brandstoetter, Veronika Sexl, Eszter Doma
Publikováno v:
Leukemia
The oncogenic protein Bcr-Abl has two major isoforms, p190Bcr-Abl and p210Bcr-Abl. While p210Bcr-Abl is the hallmark of chronic myeloid leukemia (CML), p190Bcr-Abl occurs in the majority of Philadelphia-positive acute lymphoblastic leukemia (Ph + ALL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c345e64271e0d73676513d11db0ddf
http://hdl.handle.net/10138/338406
http://hdl.handle.net/10138/338406
Autor:
Marjatta Sinisalo, Helena Hohtari, Satu Mustjoki, Kimmo Porkka, Oscar Brück, Panu E. Kovanen, Olli Kallioniemi, Riku Turkki, Sami Blom, Teijo Pellinen
Publikováno v:
Leukemia
As novel immunological treatments are gaining a foothold in the treatment of acute lymphoblastic leukemia (ALL), it is elemental to examine ALL immunobiology in more detail. We used multiplexed immunohistochemistry (mIHC) to study the immune contextu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1452001d1a49903dfb21a183448e087d
https://doi.org/10.1038/s41375-018-0360-1
https://doi.org/10.1038/s41375-018-0360-1
Autor:
Satu Mustjoki, Aleksandr Ianevski, Panu E. Kovanen, Freja Ebeling, Tero Aittokallio, Oscar Brück, Helena Hohtari, Kimmo Porkka, Susanna Lallukka-Brück, Pedro Marques Ramos, Soili Kytölä
Publikováno v:
Blood Cancer Discov
In myelodysplastic syndrome (MDS) and myeloproliferative neoplasm (MPN), bone marrow (BM) histopathology is assessed to identify dysplastic cellular morphology, cellularity, and blast excess. Yet, other morphologic findings may elude the human eye. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::807ec4f6dece279046bcc7a8d304d9dd
https://pubmed.ncbi.nlm.nih.gov/34027414
https://pubmed.ncbi.nlm.nih.gov/34027414
Autor:
Helena Hohtari, Satu Mustjoki, Freja Ebeling, P. R. Marques, Petri T. Kovanen, Tero Aittokallio, Aleksandr Ianevski, Susanna Lallukka-Brück, Oscar Brück, Kimmo Porkka, Sari Kytölä
In myelodysplastic syndrome (MDS), bone marrow (BM) histopathology is visually assessed to identify dysplastic cellular morphology, cellularity, and blast excess. Yet, many morphological findings elude the human eye. Here, we extracted visual feature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58bcf2806b4e74b0724b8f5c02e8d58c
Autor:
Matti Kankainen, Helena Hohtari, Shady Adnan Awad, Komal Kumar Javarappa, Daehong Kim, Tania Brandstoetter, Kimmo Porkka, Caroline A. Heckman, Soili Kytölä, Swapnil Potdar, Eszter Doma, Satu Mustjoki, Veronika Sexl
Publikováno v:
Blood. 134:190-190
Introduction: The oncoprotein Bcr-Abl has two major isoforms, depending on the breakpoint in BCR gene, p190 and p210. While p210 is the hallmark of chronic myeloid leukemia (CML), p190 occurs in the majority of Philadelphia-positive acute lymphoblast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6caababe5033e4446ffac2ebd4785f04
https://doi.org/10.1182/blood-2019-126584
https://doi.org/10.1182/blood-2019-126584
Autor:
Satu Mustjoki, Olli Dufva, Helena Hohtari, Swapnil Potdar, Kimmo Porkka, Krister Wennerberg, Shady Adnan Awad, Caroline A. Heckman
Publikováno v:
Blood. 132:3975-3975
Despite the advances in the treatment of acute lymphoblastic leukemia (ALL), a major fraction of adult patients still succumb to leukemia- or treatment-related events. In particular, the outcome of elderly ALL patients remains dismal. Our aim was to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4aa245daa6076afc3c225c4fccf38420
https://doi.org/10.1182/blood-2018-99-110610
https://doi.org/10.1182/blood-2018-99-110610