Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Helena Havlíková"'
Autor:
Antonin Parizek, Radmila Kancheva, Martin Hill, Helena Havlíková, Luboslav Stárka, Tomas Fait, Lyudmila Kancheva, David Cibula
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 105:166-175
This study addresses the question of whether changes in the biosynthesis and metabolism of neuroactive pregnanolone isomers (PIs) might participate in the timing of parturition in humans. The time profiles of unconjugated allopregnanolone (3alpha-hyd
Autor:
Vladimír Pouzar, Lyudmila Kancheva, Jana Vrbikova, Luboslav Stárka, Martin Hill, Radmila Kancheva, Ivan Černý, Helena Havlíková
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 96:187-200
7-Hydroxy-metabolites of dehydroepiandrosterone (DHEA) and 3beta,17beta-androstenediol (AD) possess immunomodulatory and neuroprotective properties; therefore, the measurement of these steroids in patients with autoimmune diseases or disturbances in
Autor:
Vladimír Pouzar, Lyudmila Kancheva, Luboslav Stárka, Petr Popov, Ivan Černý, Radmila Kancheva, Martin Hill, Jana Vrbikova, Helena Havlíková
Publikováno v:
Steroids. 70:515-524
Long-term alcohol consumption results in menstrual irregularities due to the inhibition of progesterone secretion. Some progesterone metabolites, including three pregnanolone isomers (PI), abate, while pregnenolone sulfate (PregS) and dehydroepiandro
Publikováno v:
Collection of Czechoslovak Chemical Communications. 69:1805-1817
Syntheses of 5α-pregnanolone derivatives (3-hydroxy-5α-pregnan-20-ones) with 3α- and 3β-configuration and 19-[O-(carboxymethyl)oxime] group were developed, starting from 19-hydroxy-20-oxopregn-5-en-3β-yl acetate. After catalytic hydrogenation, a
Autor:
Antonín Pařízek, Martin Hill, L. Stárka, Milan Meloun, Oldrich Lapcik, Radmila Kancheva, Tomas Fait, Helena Havlíková, David Cibula, Vladimír Pouzar, J Sulcová, M Bičíková, Richard Hampl, J Klak
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 82:241-250
Five 3beta-hydroxy-5-ene steroids involved in the metabolic route from pregnenolone sulfate to dehydroepiandrosterone and its sulfate, of which three are known allosteric modulators of neurotransmitter receptors, were monitored in the serum of 20 wom
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 87:2225-2231
Epitestosterone has been demonstrated to act at various levels as a weak antiandrogen. So far, its serum levels have been followed up only in males. Epitestosterone and its major circulating precursor pregnenolone sulfate and T were measured in serum
Autor:
Richard Hampl, Luboslav Stárka, Marie Bičíková, Helena Havlíková, J Klak, Martin Hill, Vladimír Pouzar
Publikováno v:
Collection of Czechoslovak Chemical Communications. 67:140-162
The importance of pregnenolone sulfate (PregS) in human physiology has increased in the last decade in connection with its neuroactivating effectviapositive modification ofN-methyl-D-aspartate receptors and negative modulation of GABA receptors. Ther
Publikováno v:
Journal of Chromatography A. 935:297-307
Recent reports demonstrated that 7-hydroxylated metabolites of dehydroepiandrosterone (DHEA) possess immunomodulatory and antiglucocorticoid properties. Increased 7α-OH-DHEA levels were found in patients with Alzheimer’s disease. Hence, measuremen
Autor:
Martin Hill, Helena Havlíková, Antonín Pařízek, Milan Meloun, Alexander Cegan, Luboslav Stárka, Richard Hampl, J Sulcová, T. Fajt, M Bičíková, J Klak, David Cibula
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 78:51-57
Time profiles of the pregnanolone isomers epipregnanolone (3 beta-hydroxy-5 beta-pregnan-20-one), allopregnanolone (3 alpha-hydroxy-5 alpha-pregnan-20-one), pregnanolone (3 alpha-hydroxy-5 beta-pregnan-20-one), and isopregnanolone (3 beta-hydroxy-5 a
Autor:
Martin Hill, Jana Vrbikova, Helena Havlíková, I. Cerny, Luboslav Stárka, Milan Meloun, Radmila Kancheva, David Cibula, Vladimír Pouzar, Lyudmila Kancheva, Petr Popov
Publikováno v:
Alcoholism, clinical and experimental research. 29(6)
BACKGROUND Alcohol abuse is associated with menstrual irregularities related to the inhibition of progesterone secretion involved in regulation of the menstrual cycle. Reduced progesterone metabolites, including pregnanolone isomers (PIs), are effici