Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Helena Grufman"'
Autor:
Alexandru Schiopu, M.A. Karsdal, U. auf dem Keller, Annelie Shami, Joakim Alfredsson, Federica Genovese, S Holm Nielsen, Lena Jonasson, Eva Swahn, Helena Grufman, Jan-Åke Nilsson, Andreas Edsfeldt, Isabel Gonçalves, Troels Yndigegn
Publikováno v:
European Heart Journal. 41
Background Following acute myocardial infarction (MI), the left ventricle undergoes molecular and extracellular matrix (ECM) changes. The ECM is a dynamic structure with a potential role in cardiac remodeling post-MI. Collagens are the major componen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37e47f5d34c2b81aa61be339f5a5eb6b
https://doi.org/10.1093/ehjci/ehaa946.1685
https://doi.org/10.1093/ehjci/ehaa946.1685
Autor:
Marju Orho-Melander, Andreas Edsfeldt, Giuseppe Asciutto, Olle Melander, Helena Grufman, Jan Borén, Jan Nilsson, Rachel M. Fisher, Isabel Gonçalves, Mihaela Nitulescu, Pontus Dunér, Marcus Ståhlman, Ana Persson, Ines G. Mollet
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 36:1132-1140
Objective— Lipids are central to the development of atherosclerotic plaques. Specifically, which lipids are culprits remains controversial, and promising targets have failed in clinical studies. Sphingolipids are bioactive lipids present in atheros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070c218494a6b6cabb740567dadc90d0
https://doi.org/10.1161/atvbaha.116.305675
https://doi.org/10.1161/atvbaha.116.305675
Autor:
Razvan Gheorghita Mares, Goran Marinković, Jan Nilsson, Helena Grufman, Troels Yndigegn, Helena Grauen Larsen, Isabel Gonçalves, Alexandru Schiopu
Publikováno v:
Atherosclerosis. 287
Background and aims The pro-inflammatory alarmin S100A12 (EN-RAGE) and the soluble form of its receptor, the receptor for advanced glycation endproducts (sRAGE), have diverging roles in cardiovascular disease. In experimental studies, S100A12 promote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5b489f02f1e68dea18d491b7f0a17b
https://pubmed.ncbi.nlm.nih.gov/31181415
https://pubmed.ncbi.nlm.nih.gov/31181415
Autor:
Bo Hedblad, Agneta Siegbahn, Isabel Gonçalves, Sara Rattik, Alexandru Schiopu, Pontus Dunér, Jan Nilsson, Eva Bengtsson, Maria Wigren, Harry Björkbacka, Gunilla Nordin Fredrikson, Andreas Edsfeldt, Helena Grufman
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 35:222-228
Objective— Rupture of atherosclerotic plaques is the major cause of acute coronary events (CEs). Plaque destabilization is the consequence of an imbalance between inflammatory-driven degradation of fibrous tissue and smooth muscle cell–dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30f4729716d19d161b3eecf7ffb98bf
https://doi.org/10.1161/atvbaha.114.304369
https://doi.org/10.1161/atvbaha.114.304369
Publikováno v:
Cytokine. 122
Background and aims IL-27 is an immunoregulatory cytokine belonging to the IL-6/IL-12 family that was found to be elevated in acute coronary syndrome (ACS) patients. We investigated whether IL-27 is related to post-ischemic cardiac remodeling and lon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::829e0dd5c2e6ba4cd74502643f29dd2e
https://pubmed.ncbi.nlm.nih.gov/29428559
https://pubmed.ncbi.nlm.nih.gov/29428559
Autor:
Ana Persson, Andreas Edsfeldt, Pontus Dunér, Harry Björkbacka, Olle Melander, Helena Grufman, Jan Nilsson, Marie Mn Nilsson, Eva Bengtsson, Mihaela Nitulescu, Marju Orho-Melander, Isabel Gonçalves, Inês G. Mollet
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 34:2143-2150
Objective— Diabetes mellitus (DM) type II is increasing rapidly worldwide. Patients with DM II have a greater atherosclerotic burden and higher risk of developing cardiovascular complications. Inflammation has been proposed as the main cause for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82093637c2ba1f73088737df19ebb087
https://doi.org/10.1161/atvbaha.114.303414
https://doi.org/10.1161/atvbaha.114.303414
Autor:
Isabel Gonçalves, Jan Nilsson, Mihaela Nitulescu, Marie Mn Nilsson, Ana Persson, Helena Grufman, Andreas Edsfeldt
Publikováno v:
Journal of Internal Medicine. 275:127-133
It is well established that subjects with moderately elevated plasma levels of C-reactive protein (CRP) have an increased risk of development of cardiovascular events. As atherosclerosis is a disease characterized by chronic arterial inflammation, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd659cf0c5eff4b99562093e96943dcf
https://doi.org/10.1111/joim.12133
https://doi.org/10.1111/joim.12133
Autor:
Jerzy Adamski, Marie Mn Nilsson, Harry Björkbacka, Andreas Edsfeldt, Na Young Ko, Mihaela Nitulescu, Katarina Berg, Helena Grufman, Cornelia Prehn, Isabel Gonçalves, Jan Nilsson, Ana Persson
Publikováno v:
Arterioscler. Thromb. Vasc. Biol. 32, 1505-1512 (2012)
Objectives— To determine whether the level of lysophosphatidylcholine (lysoPC) generated by lipoprotein-associated phospholipase A2 (Lp-PLA2) is associated with severity of inflammation in human atherosclerotic plaques. Elevated plasma Lp-PLA2 is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89307e624a40dad1a7fabec6608b626a
https://doi.org/10.1161/atvbaha.112.249854
https://doi.org/10.1161/atvbaha.112.249854
Autor:
Fong To, Isabel Gonçalves, Mihaela Nitulescu, Jan Nilsson, Pontus Dunér, Eva Bengtsson, Helena Grufman, Andreas Edsfeldt
Publikováno v:
Atherosclerosis; 240(1), pp 26-32 (2015)
Subendothelial LDL-adhesion and its subsequent oxidation are considered as key events in the development of atherosclerotic lesions. During oxidation of LDL, reactive aldehydes such as malondialdehyde (MDA) are formed, which modify apolipoprotein B10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc1fda8cc5d76a1f3e9cece671c55de9
http://lup.lub.lu.se/record/5265128
http://lup.lub.lu.se/record/5265128
Autor:
Isabel Gonçalves, Giuseppe Asciutto, Marie Mn Nilsson, Jan Nilsson, Mihaela Nitulescu, Helena Grufman, Andreas Edsfeldt, Ana Persson
Publikováno v:
Atherosclerosis; 241(2), pp 443-449 (2015)
Inflammation is a key factor in the development of plaque rupture and acute cardiovascular events. Although imaging techniques can be used to identify vulnerable atherosclerotic plaques, we are lacking non-invasive methods, such as plasma markers of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2b119763153009841c4334f4fe348d
https://pubmed.ncbi.nlm.nih.gov/26074318
https://pubmed.ncbi.nlm.nih.gov/26074318