Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Helena Gauani"'
Autor:
Donna M. Konicek, Adam J. Plaunt, Sachin Gharse, Sasha J. Rose, Arielle Dorfman, Amruta Sabnis, Thomas Baker, Helena Gauani, Donald Chun, Zhili Li, Walter R. Perkins, David Cipolla, Vladimir S. Malinin
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2250 (2023)
The increased prevalence of pulmonary methicillin-resistant Staphylococcus aureus (MRSA) infection in patients living with cystic fibrosis (CF) is concerning due to a correlation with reduced life expectancy and lack of available treatment options. R
Externí odkaz:
https://doaj.org/article/489479d94ae3433599532bcbf80b551d
Autor:
Helena Gauani, Thomas Baker, Zhili Li, Vladimir S. Malinin, Walter R. Perkins, Eugene J. Sullivan, David Cipolla
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 934 (2023)
Treprostinil palmitil (TP), a prodrug of treprostinil, is being developed as an inhalation powder (TPIP) for the treatment of patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension due to interstitial lung disease (PH-ILD). In
Externí odkaz:
https://doaj.org/article/901785b5f5b0470397f70a9f2a5e4176
Autor:
Helena Gauani, Thomas Baker, Zhili Li, Vladimir S. Malinin, Walter Perkins, Eugene Sullivan, David Cipolla
Publikováno v:
Frontiers in Drug Delivery, Vol 2 (2022)
Treprostinil palmitil (TP) is a prodrug of treprostinil that has been formulated as an inhaled powder, termed TPIP, for evaluation in patients with pulmonary arterial hypertension. In these characterization studies we investigated the aerosol perform
Externí odkaz:
https://doaj.org/article/cfdaeee1ac7e4fb4aa9fea582832480b
Autor:
Adam J. Plaunt, Sadikul Islam, Tony Macaluso, Helena Gauani, Thomas Baker, Donald Chun, Veronica Viramontes, Christina Chang, Michel R. Corboz, Richard W. Chapman, Zhili Li, David C. Cipolla, Walter R. Perkins, Vladimir S. Malinin
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2, p 548 (2021)
Treprostinil palmitil (TP) is a prodrug of treprostinil (TRE), a pulmonary vasodilator that has been previously formulated for inhaled administration via a nebulizer. TP demonstrates a sustained presence in the lungs with reduced systemic exposure an
Externí odkaz:
https://doaj.org/article/4c4d58c1a0184939b9ca33128da7d82b
Autor:
Michel R. Corboz, Adam J. Plaunt, Vladimir S. Malinin, Zhili Li, Helena Gauani, Donald Chun, David Cipolla, Walter R. Perkins, Richard W. Chapman
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 383(1)
Treprostinil palmitil (TP), a long-acting inhaled pulmonary vasodilator prodrug of treprostinil (TRE), has beneficial effects in a Sugen5416/hypoxia (Su/Hx) rat model of pulmonary arterial hypertension (PAH) that compare favorably to the oral phospho
Autor:
Richard W. Chapman, Walter Perkins, Tony Macaluso, Donald Chun, Vladimir Malinin, Zhili Li, Helena Gauani, Sadikul Islam, David Cipolla, Veronica Viramontes, Adam J. Plaunt, Michel R. Corboz, Thomas Baker, Christina Chang
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 2
International Journal of Molecular Sciences, Vol 22, Iss 548, p 548 (2021)
Volume 22
Issue 2
International Journal of Molecular Sciences, Vol 22, Iss 548, p 548 (2021)
Treprostinil palmitil (TP) is a prodrug of treprostinil (TRE), a pulmonary vasodilator that has been previously formulated for inhaled administration via a nebulizer. TP demonstrates a sustained presence in the lungs with reduced systemic exposure an
Autor:
Richard W. Chapman, Zhili Li, Helena Gauani, Charles E. Laurent, Michel R. Corboz, Walter Perkins, C Brodeur, Vladmir Malinin, Adam J. Plaunt, Donald Chun, Sandra Gagnon, David Cipolla
Publikováno v:
Pulmonary hypertension.
Introduction: Sugen/Hypoxia (Su/Hx) challenge to rats produces many pathophysiological markers of human pulmonary arterial hypertension (PAH). Aim: Compare the effects of TPIS, a long-acting prodrug of treprostinil (TRE) and the PDE5 inhibitor Sild o
Autor:
Walter Perkins, Zhili Li, Helena Gauani, Adam J. Plaunt, Michel R. Corboz, Vladimir Malinin, David Cipolla, Donald Chun, Richard W. Chapman, Sandra Gagnon, C Brodeur
Publikováno v:
Pulmonary hypertension.
Introduction: Continuous infusion with intravenous (IV) treprostinil (TRE) results in desensitization of the prostacyclin receptor and requires dose escalation to maintain its efficacy over time. It is unknown if desensitization to TPIS, a long-actin
Autor:
Donna M. Konicek, Dany Salvail, Han Yin, Vladimir Malinin, Adam J. Plaunt, Richard W. Chapman, Charles E. Laurent, Chad Dziak, Zhili Li, Helena Gauani, Walter Perkins, Michel R. Corboz, Franziska Leifer
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 49:104-111
INS1009 is a long acting pulmonary vasodilator prodrug of treprostinil (TRE) that is formulated in a lipid nanoparticle for inhaled delivery by nebulization. This study examined the ability of INS1009 to inhibit vasoconstriction in the pulmonary vasc
Autor:
Walter Perkins, Richard W. Chapman, Michel R. Corboz, David Cipolla, Vladimir Malinin, Zhili Li, Helena Gauani, Donald Chun, Adam J. Plaunt
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 66:101983
Treprostinil palmitil (TP) is an inhaled long-acting pulmonary vasodilator prodrug of treprostinil (TRE) that has been formulated for delivery as a suspension (treprostinil palmitil inhalation suspension; TPIS) and as a dry powder (treprostinil palmi