Brain biomarkers and pre-injury cognition are associated with long-term cognitive outcome in children with traumatic brain injury

Autor: Amy A. Wilkinson, Maureen Dennis, Nevena Simic, Margot J. Taylor, Benjamin R. Morgan, Helena Frndova, Karen Choong, Craig Campbell, Douglas Fraser, Vicki Anderson, Anne-Marie Guerguerian, Russell Schachar, Jamie Hutchison, For the Canadian Critical Care Trials Group (CCCTG), The Canadian Critical Care Translational Biology Group (CCCTBG)

Publikováno v: BMC Pediatrics, Vol 17, Iss 1, Pp 1-11 (2017)

Abstract Background Children with traumatic brain injury (TBI) are frequently at risk of long-term impairments of attention and executive functioning but these problems are difficult to predict. Although deficits have been reported to vary with injur

Externí odkaz: https://doaj.org/article/e019d00d9d214ad0812b8ae3f64d4880

Death and Dying in Hospitalized Pediatric Patients: A Prospective Multicenter, Multinational Study

Autor: Kristen Middaugh, Jessica Nicoll, Chris Parshuram, Ari R. Joffe, Helena Frndova, Karen Dryden-Palmer, Vinay M. Nadkarni, Catherine Farrell, Leah Szadkowski, David Wensley, Jacques Lacroix, Elizabeth A. Hunt, James S. Hutchison, George Tomlinson, Martin Gray, Ronald Gottesman

Publikováno v: Journal of Palliative Medicine. 25:227-233

Background: For hospitalized children admitted outside of a critical care unit, the location, mode of death, "do-not-resuscitate" order (DNR) use, and involvement of palliative care teams have not been described across high-income countries. Objectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a683cba3b3caabb90c7e6ec2e1602444
https://doi.org/10.1089/jpm.2021.0205

Dosing of enteral acetaminophen in critically ill children: a cohort study

Autor: Helena Frndova, Nadia Roumeliotis, Christopher S. Parshuram, Eleanor Pullenayegum, Paula A. Rochon, Anna Taddio

Publikováno v: Archives of Disease in Childhood. 107:388-393

ObjectiveAcetaminophen is the most common medication prescribed in children’s hospitals. The aim of the study was to estimate the frequency and risk factors for acetaminophen underdosing and overdosing in the paediatric intensive care unit (PICU).D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b56f0780461d19b3abe9016606bd621
https://doi.org/10.1136/archdischild-2021-321952

Alterations in coordinated EEG activity precede the development of seizures in comatose children

Autor: Urs Ribary, Sam M. Doesburg, Cecil D. Hahn, William Gallentine, Cristina Go, Dragos A. Nita, James S. Hutchison, Kendall B. Nash, Helena Frndova, Cornelis J. Stam, Vasily A. Vakorin, Eric T. Payne, Nicholas S. Abend, O. Carter Snead, Ilse E. C. W. van Straaten, Christopher S. Parshuram, Kristin McBain

Publikováno v: Vakorin, V A, Nita, D A, Payne, E T, McBain, K L, Frndova, H, Go, C, Ribary, U, Abend, N S, Gallentine, W B, Nash, K B, Hutchison, J S, Parshuram, C S, Snead, O C, van Straaten, I E C W, Stam, C J, Doesburg, S M & Hahn, C D 2021, ' Alterations in coordinated EEG activity precede the development of seizures in comatose children ', Clinical Neurophysiology, vol. 132, no. 7, pp. 1505-1514 . https://doi.org/10.1016/j.clinph.2021.03.015
Clinical Neurophysiology, 132(7), 1505-1514. Elsevier Ireland Ltd

Objective We aimed to test the hypothesis that computational features of the first several minutes of EEG recording can be used to estimate the risk for development of acute seizures in comatose critically-ill children. Methods In a prospective cohor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd43be04d8994a8cbb43d4ddeb2e0e7
https://research.vumc.nl/en/publications/3cc3407f-ce16-4aea-9987-210b5c3dc1c8

Characterisation of serum total tau following paediatric traumatic brain injury: a case-control study

Autor: Alison Crichton, Amy A. Wilkinson, Helena Frndova, Anne-Marie Guerguerian, Carmel Delzoppo, Catherine Farrell, Kathy Boutis, Cheryl L. Wellington, Miriam H. Beauchamp, Jasmine Gill, Khosrow Adeli, Serum Biomarkers, Sophie Stukas, Franz E Babl, Vicki Anderson, Jamie Hutchison, Victoria Higgins, Evyatar Hubara, Mardee Greenham

Publikováno v: The Lancet. Childadolescent health. 3(8)

Summary Background Traumatic brain injury (TBI) is a major health problem in children. Blood-based biomarkers interpreted by use of normative values might improve the accuracy of diagnosis. Ultrasensitive assays can quantify serum concentrations of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a32a7ffd92e17f6a5075bcd83df1de8
https://pubmed.ncbi.nlm.nih.gov/31231067