Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Helena Edlund"'
Publikováno v:
Heliyon, Vol 10, Iss 12, Pp e32456- (2024)
Aims: Individuals of African ancestry (AA) present with lower insulin sensitivity compared to their European counterparts (EA). Studies show ethnic differences in skeletal muscle fiber type (lower type I fibers in AA), muscle fat oxidation capacity (
Externí odkaz:
https://doaj.org/article/d2fa1afed4a34ae583d5dc8637c24f8c
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)
Abstract Although insulin mediated glucose uptake in skeletal muscle is a major mechanism ensuring glucose disposal in humans, glucose effectiveness, i.e., the ability of glucose itself to stimulate its own uptake independent of insulin, accounts for
Externí odkaz:
https://doaj.org/article/16e5c9b07f6c482bbca9768f696eb50b
Autor:
Ana López-Pérez, Stefan Norlin, Pär Steneberg, Silvia Remeseiro, Helena Edlund, Andreas Hörnblad
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract AMP-activated protein kinase (AMPK) has an important role in cellular energy homeostasis and has emerged as a promising target for treatment of Type 2 Diabetes (T2D) due to its beneficial effects on insulin sensitivity and glucose homeostasi
Externí odkaz:
https://doaj.org/article/fb720488e1fb44268248dcc58487c00b
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
Ericsson et al. show in aged mice that the panAMPK activator O304 prevents and reverts age-associated hyperinsulinemia and insulin resistance, as well as improving cardiac function and exercise capacity. O304 thus functions as an exercise mimetic and
Externí odkaz:
https://doaj.org/article/64086dace18d49488ccbf433e4550abd
Autor:
Marija Mucibabic, Pär Steneberg, Emmelie Lidh, Jurate Straseviciene, Agnieszka Ziolkowska, Ulf Dahl, Emma Lindahl, Helena Edlund
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract Type 2 diabetes (T2D), alike Parkinson’s disease (PD), belongs to the group of protein misfolding diseases (PMDs), which share aggregation of misfolded proteins as a hallmark. Although the major aggregating peptide in β-cells of T2D patie
Externí odkaz:
https://doaj.org/article/c38137531696423c9b543012d50e5640
Autor:
Maria Oström, Kelly A Loffler, Sara Edfalk, Lars Selander, Ulf Dahl, Camillo Ricordi, Jongmin Jeon, Mayrin Correa-Medina, Juan Diez, Helena Edlund
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2841 (2008)
The identification of secreted factors that can selectively stimulate the generation of insulin producing beta-cells from stem and/or progenitor cells represent a significant step in the development of stem cell-based beta-cell replacement therapy. B
Externí odkaz:
https://doaj.org/article/95c05dce62df4d42b4898995beef4ce5
Autor:
Zhongqing He, Shringi Sharma, Joseph Ware, Helena Edlund, Helen Wei, Núria Buil-Bruna, Marshall Baek, Helen Tomkinson, Karthick Vishwanathan, Miné de Kock, Rakesh K. Raman, Huan Liu, Priti Patel
Publikováno v:
British Journal of Clinical Pharmacology. 88:2284-2296
Aims Examine relationships between the systemic exposure of acalabrutinib, a highly selective, next-generation Bruton tyrosine kinase inhibitor, and its active metabolite (ACP-5862) vs. efficacy and safety responses in patients with B-cell malignanci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d661a62dde63d808a29a323a3d8a1f34
https://doi.org/10.1111/bcp.15087
https://doi.org/10.1111/bcp.15087
Autor:
Helena Edlund, Pär Steneberg, Ulf Dahl, Jurate Straseviciene, Marija Mucibabic, Emma Lindahl, Emmelie Lidh, Agnieszka Ziolkowska
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Type 2 diabetes (T2D), alike Parkinson’s disease (PD), belongs to the group of protein misfolding diseases (PMDs), which share aggregation of misfolded proteins as a hallmark. Although the major aggregating peptide in β-cells of T2D patients is Is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::218eddc3d65529afb4e2b48a0f75577b
https://doaj.org/article/c38137531696423c9b543012d50e5640
https://doaj.org/article/c38137531696423c9b543012d50e5640
Autor:
Staffan, Berg, Helena, Edlund, William, R F Goundry, Christel, A S Bergström, Nigel M, Davies
Publikováno v:
International Journal of Pharmaceutics. 628:122238
This paper reviews many of the properties of a peptide that need to be considered prior to development as an oral dosage form when co-formulated with a permeation enhancer to improve oral bioavailability, including the importance and implications of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776c7d75a0ccc84b2ec371478206d378
https://doi.org/10.1016/j.ijpharm.2022.122238
https://doi.org/10.1016/j.ijpharm.2022.122238
Autor:
Francesco Bellanti, Núria Buil-Bruna, Helena Edlund, Karthick Vishwanathan, Shringi Sharma, Huan Liu, Joseph Ware, Helen Tomkinson
Publikováno v:
British journal of clinical pharmacology. 88(2)
This analysis aimed to describe the pharmacokinetics (PK) of acalabrutinib and its active metabolite, ACP-5862. A total of 8935 acalabrutinib samples from 712 subjects and 2394 ACP-5862 samples from 304 subjects from 12 clinical studies in patients w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b54a3b6d225983a07fccf2c6c067452e
https://pubmed.ncbi.nlm.nih.gov/34265100
https://pubmed.ncbi.nlm.nih.gov/34265100