Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Helena E Richardson"'
Autor:
Tamara Zoranovic, Jan Manent, Lee Willoughby, Ricardo Matos de Simoes, John E La Marca, Sofya Golenkina, Xia Cuiping, Susanne Gruber, Belinda Angjeli, Elisabeth Eva Kanitz, Shane J F Cronin, G Gregory Neely, Andreas Wernitznig, Patrick O Humbert, Kaylene J Simpson, Constantine S Mitsiades, Helena E Richardson, Josef M Penninger
Publikováno v:
PLoS Genetics, Vol 14, Iss 10, p e1007688 (2018)
Oncogenic mutations in the small GTPase Ras contribute to ~30% of human cancers. However, Ras mutations alone are insufficient for tumorigenesis, therefore it is paramount to identify cooperating cancer-relevant signaling pathways. We devised an in v
Externí odkaz:
https://doaj.org/article/398b05ace50540ebbc5d12234222f441
Autor:
Karen Doggett, Nezaket Turkel, Lee F Willoughby, Jason Ellul, Michael J Murray, Helena E Richardson, Anthony M Brumby
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132987 (2015)
During tumorigenesis, pathways that promote the epithelial-to-mesenchymal transition (EMT) can both facilitate metastasis and endow tumor cells with cancer stem cell properties. To gain a greater understanding of how these properties are interlinked
Externí odkaz:
https://doaj.org/article/1ab12ccb8e4d4afaadea726639471aa5
Autor:
Chwee Tat Koe, Song Li, Fabrizio Rossi, Jack Jing Lin Wong, Yan Wang, Zhizhuo Zhang, Keng Chen, Sherry Shiying Aw, Helena E Richardson, Paul Robson, Wing-Kin Sung, Fengwei Yu, Cayetano Gonzalez, Hongyan Wang
Publikováno v:
eLife, Vol 3 (2014)
The control of self-renewal and differentiation of neural stem and progenitor cells is a crucial issue in stem cell and cancer biology. Drosophila type II neuroblast lineages are prone to developing impaired neuroblast homeostasis if the limited self
Externí odkaz:
https://doaj.org/article/0793e30af78c4f4c8651717beb850fa3
Autor:
Nezaket Turkel, Virender K Sahota, Jessica E Bolden, Karen R Goulding, Karen Doggett, Lee F Willoughby, Enrique Blanco, Enrique Martin-Blanco, Montserrat Corominas, Jason Ellul, Toshiro Aigaki, Helena E Richardson, Anthony M Brumby
Publikováno v:
PLoS Genetics, Vol 9, Iss 7, p e1003627 (2013)
The capacity of tumour cells to maintain continual overgrowth potential has been linked to the commandeering of normal self-renewal pathways. Using an epithelial cancer model in Drosophila melanogaster, we carried out an overexpression screen for onc
Externí odkaz:
https://doaj.org/article/dbc1cfd619154fcfa5f7489343516668
Autor:
John E. La Marca, Robert W. Ely, Sarah T. Diepstraten, Peter Burke, Gemma L. Kelly, Patrick O. Humbert, Helena E. Richardson
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 3 (2023)
Externí odkaz:
https://doaj.org/article/e9522fc36290440fb2985f54b8531064
Autor:
John E. La Marca, Lee F. Willoughby, Kirsten Allan, Marta Portela, Pei Kee Goh, Tony Tiganis, Helena E. Richardson
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 12732 (2021)
Tissue homeostasis via the elimination of aberrant cells is fundamental for organism survival. Cell competition is a key homeostatic mechanism, contributing to the recognition and elimination of aberrant cells, preventing their malignant progression
Externí odkaz:
https://doaj.org/article/e643c8c6a14446759b39c36b06d3c9a4
Autor:
Linda M. Parsons, Nicola A. Grzeschik, Kasun Amaratunga, Peter Burke, Leonie M. Quinn, Helena E. Richardson
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 8, Pp 2497-2509 (2017)
In both Drosophila melanogaster and mammalian systems, epithelial structure and underlying cell polarity are essential for proper tissue morphogenesis and organ growth. Cell polarity interfaces with multiple cellular processes that are regulated by t
Externí odkaz:
https://doaj.org/article/95093d56a0a5460d9e89c05e5d5747d9
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 16, p 5919 (2020)
n/a
Externí odkaz:
https://doaj.org/article/3c7bf367143e4f6ab4e3c3d3d8ef5dab
Autor:
Scott G. Daniel, Atlantis D. Russ, Kathryn M. Guthridge, Ammad I. Raina, Patricia S. Estes, Linda M. Parsons, Helena E. Richardson, Joyce A. Schroeder, Daniela C. Zarnescu
Publikováno v:
Biology Open, Vol 7, Iss 1 (2018)
Drosophila lethal giant larvae (lgl) encodes a conserved tumor suppressor with established roles in cell polarity, asymmetric division, and proliferation control. Lgl's human orthologs, HUGL1 and HUGL2, are altered in human cancers, however, its mech
Externí odkaz:
https://doaj.org/article/0055a1444c534fabbc6911f81cd3e648
Autor:
Nezaket Turkel, Marta Portela, Carole Poon, Jason Li, Anthony M. Brumby, Helena E. Richardson
Publikováno v:
Biology Open, Vol 4, Iss 8, Pp 1024-1039 (2015)
The deregulation of cell polarity or cytoskeletal regulators is a common occurrence in human epithelial cancers. Moreover, there is accumulating evidence in human epithelial cancer that BTB-ZF genes, such as Bcl6 and ZBTB7A, are oncogenic. From our p
Externí odkaz:
https://doaj.org/article/6079cdb7315b4a5e99c1b41daf852ec5