Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Helena D. Pickford"'
Autor:
Nils Frank, Jeremy Nugent, Bethany R. Shire, Helena D. Pickford, Patrick Rabe, Alistair J. Sterling, Tryfon Zarganes-Tzitzikas, Thomas Grimes, Amber L. Thompson, Russell C. Smith, Christopher J. Schofield, Paul E. Brennan, Fernanda Duarte, Edward A. Anderson
Publikováno v:
Nature. 611:721-726
Small-ring cage hydrocarbons are popular bioisosteres (molecular replacements) for commonly-foundpara-substituted benzene rings in drug design1. The utility of these cage structures derives from their superior pharmacokinetic properties compared to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27148d6fff34bca82ee0e073bf600ca9
https://doi.org/10.1038/s41586-022-05290-z
https://doi.org/10.1038/s41586-022-05290-z
Autor:
Edward A. Anderson, Kirsten E. Christensen, Zixuan Tong, Helena D. Pickford, Yubo Jiang, Jeremy Nugent, Philip J. Smith
Publikováno v:
Organic Letters. 23:6547-6552
Yndiamides (bis-N-substituted alkynes) are valuable precursors to azacycles. Here we report a cycloisomerization/1,2-sulfonyl migration of alkynyl-yndiamides to form tetrahydropyrrolopyrroles, unprecedented heterocyclic scaffolds that are relevant to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e914b5ef7c51ba2da2d1bf8ec849db6
https://doi.org/10.1021/acs.orglett.1c02360
https://doi.org/10.1021/acs.orglett.1c02360
Synthesis of All‐Carbon Disubstituted Bicyclo[1.1.1]pentanes by Iron‐Catalyzed Kumada Cross‐Coupling
Autor:
Houlsby Ian Thomas Tinmouth, Helena D. Pickford, Dimitri F. J. Caputo, Edward A. Anderson, Frank Nightingale, Bethany R. Shire, James J. Mousseau, Jeremy Nugent
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International Ed. in English)
1,3‐Disubstituted bicyclo[1.1.1]pentanes (BCPs) are important motifs in drug design as surrogates for p‐substituted arenes and alkynes. Access to all‐carbon disubstituted BCPs via cross‐coupling has to date been limited to use of the BCP as t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c05f0a1c0c49961074029790e92191
https://doi.org/10.1002/anie.202004090
https://doi.org/10.1002/anie.202004090
Autor:
Helena D, Pickford, Jeremy, Nugent, Benjamin, Owen, James J, Mousseau, Russell C, Smith, Edward A, Anderson
Publikováno v:
Journal of the American Chemical Society. 143(26)
Bicyclo[1.1.1]pentylamines (BCPAs) are of growing importance to the pharmaceutical industry as sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16eb70a2ab8b8844e92f17504b1e416d
https://pubmed.ncbi.nlm.nih.gov/34161076
https://pubmed.ncbi.nlm.nih.gov/34161076
Autor:
Dimitri F. J. Caputo, Frank Nightingale, Houlsby Ian Thomas Tinmouth, Edward A. Anderson, Jeremy Nugent, Bethany R. Shire, JamesJ. Mousseau, Helena D. Pickford
1,3-Disubstituted bicyclo[1.1.1]pentanes (BCPs) are important motifs in drug design as surrogates for p-substituted arenes and alkynes. Access to all-carbon disubstituted BCPs via cross coupling has to date been limited to use of the BCP as the organ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101d10c4b1b073408adda94d91b220f1
https://doi.org/10.26434/chemrxiv.12009390
https://doi.org/10.26434/chemrxiv.12009390
Autor:
Jeremy Nugent, Dimitri F. J. Caputo, Edward A. Anderson, Fernanda Duarte, JamesJ. Mousseau, Benjamin Owen, Marie L. J. Wong, Steven J. Mansfield, Alistair J. Sterling, Carlos Arróniz, Bethany R. Shire, Helena D. Pickford
The use of visible light to activate transition metal catalysts towards redox processes has transformed the way organic molecules can be constructed. Promotion of an electron to an excited state enables the generation of organic radicals through elec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::487301895a3f0a24a5b226dd918df955
https://doi.org/10.26434/chemrxiv.7958765
https://doi.org/10.26434/chemrxiv.7958765
Autor:
Fernanda Duarte, Edward A. Anderson, Jeremy Nugent, Bethany R. Shire, Benjamin Owen, Helena D. Pickford, Dimitri F. J. Caputo, Alistair J. Sterling, Marie L. J. Wong, Carlos Arroniz, James J. Mousseau, Steven J. Mansfield
Publikováno v:
ACS Catalysis
Photoredox catalysis has transformed the landscape of radical-based synthetic chemistry. Additions of radicals generated through photoredox catalysis to carbon-carbon π-bonds are well-established; however, this approach has yet to be applied to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc282647156bd71ad3c5e3e3e150032
Autor:
Helena D. Pickford, Vasyl Ripenko, Ryan E. McNamee, Serhii Holovchuk, Amber L. Thompson, Russell C. Smith, Pavel K. Mykhailiuk, Edward A. Anderson
Publikováno v:
Angewandte Chemie International Edition
Sulfonylated aromatics are commonplace motifs in drugs and agrochemicals. However, methods for the direct synthesis of sulfonylated non-classical arene bioisosteres, which could improve the physicochemical properties of drug and agrochemical candidat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c0c1ee5f07cf6881510705fa29b4b67