Zobrazeno 1 - 10
of 1 295
pro vyhledávání: '"Helena Costa"'
Autor:
Shitalben Patel, Marie Karlsson, Joseph T. Klahn, Frank Gambino, Jr., Helena Costa, Kathleen A. McGuire, Christina K. Baumgartner, Jon Williams, Sarah Sandoz, James E. Kath
Publikováno v:
SLAS Discovery, Vol 29, Iss 2, Pp 100135- (2024)
The cellular thermal shift assay (CETSA®) is a target engagement method widely used for preclinical characterization of small molecule compounds. CETSA® has been used for semi-quantitative readouts in whole blood with PBMC isolation, and quantitati
Externí odkaz:
https://doaj.org/article/80857a2b20534901930e128e510dcb8b
Autor:
Helena Costa-Verdera, Fanny Collaud, Christopher R. Riling, Pauline Sellier, Jayme M. L. Nordin, G. Michael Preston, Umut Cagin, Julien Fabregue, Simon Barral, Maryse Moya-Nilges, Jacomina Krijnse-Locker, Laetitia van Wittenberghe, Natalie Daniele, Bernard Gjata, Jeremie Cosette, Catalina Abad, Marcelo Simon-Sola, Severine Charles, Mathew Li, Marco Crosariol, Tom Antrilli, William J. Quinn, David A. Gross, Olivier Boyer, Xavier M. Anguela, Sean M. Armour, Pasqualina Colella, Giuseppe Ronzitti, Federico Mingozzi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Pompe disease is currently treated with enzyme replacement therapy (ERT) with recombinant human acid alpha-glucosidase (GAA). Here, the authors show hepatic-directed gene therapy with AAV vectors enhances GAA bioavailability compared with ERT, result
Externí odkaz:
https://doaj.org/article/ecdd7a66d5fe4b0e825ff6e616f835cf
Autor:
Sabina Luszczak, Benjamin S. Simpson, Urszula Stopka-Farooqui, Vignesh Krishna Sathyadevan, Lina M. Carmona Echeverria, Christopher Kumar, Helena Costa, Aiman Haider, Alex Freeman, Charles Jameson, Marzena Ratynska, Imen Ben-Salha, Ashwin Sridhar, Greg Shaw, John D. Kelly, Hayley Pye, Kathy A. Gately, Hayley C. Whitaker, Susan Heavey
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract PIM and PI3K/mTOR pathways are often dysregulated in prostate cancer, and may lead to decreased survival, increased metastasis and invasion. The pathways are heavily interconnected and act on a variety of common effectors that can lead to th
Externí odkaz:
https://doaj.org/article/5720892a10484524bbddcc6413152966
Autor:
Jérôme Poupiot, Helena Costa Verdera, Romain Hardet, Pasqualina Colella, Fanny Collaud, Laurent Bartolo, Jean Davoust, Peggy Sanatine, Federico Mingozzi, Isabelle Richard, Giuseppe Ronzitti
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss , Pp 83-100 (2019)
The pro-tolerogenic environment of the liver makes this tissue an ideal target for gene replacement strategies. In other peripheral tissues such as the skeletal muscle, anti-transgene immune response can result in partial or complete clearance of the
Externí odkaz:
https://doaj.org/article/6845d6f4cd904df4a534435ae9208607
Autor:
Helena Costa, Andrew Rogan, Christopher Zadra, Oddbjørn Larsen, Audun H. Rikardsen, Courtney Waugh
Publikováno v:
Drones, Vol 7, Iss 1, p 15 (2022)
Analysis of cetacean blow offers a unique potential for non-invasive assessments of their health. In recent years, the use of uncrewed aerial vehicles (UAVs) has revolutionized the way these samples are collected. However, the high cost and expertise
Externí odkaz:
https://doaj.org/article/d5e38f4ed4c1477e9394de95b23ccf8d
Autor:
Pasqualina Colella, Pauline Sellier, Helena Costa Verdera, Francesco Puzzo, Laetitia van Wittenberghe, Nicolas Guerchet, Nathalie Daniele, Bernard Gjata, Solenne Marmier, Severine Charles, Marcelo Simon Sola, Isabella Ragone, Christian Leborgne, Fanny Collaud, Federico Mingozzi
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 12, Iss , Pp 85-101 (2019)
Hepatocyte-restricted, AAV-mediated gene transfer is being used to provide sustained, tolerogenic transgene expression in gene therapy. However, given the episomal status of the AAV genome, this approach cannot be applied to pediatric disorders when
Externí odkaz:
https://doaj.org/article/a3d927f9d1284167b0026e3289c81292
Autor:
Maria López-Parra, Francesc Zamora-Carmona, Mònica Sianes-Gallén, Esmeralda López-González, Dolors Gil-Rey, Helena Costa-Ventura, Miriam Borrás-Sánchez, Gemma Rayo-Posadas, Marta Arizu-Puigvert, Roser Vives-Vilagut
Publikováno v:
Healthcare, Vol 10, Iss 6, p 1036 (2022)
The informed consent (IC) of subjects participating in experimental studies is the mainstay to comply with the ethical principle of autonomy to ensure that the participation is voluntary. This experience was performed within the context of a single-c
Externí odkaz:
https://doaj.org/article/74efc821bd724587abd6b2c1e05a3e5c
Autor:
Helena Costa, Jörn Klein, Eva M. Breines, Hendrik H. Nollens, Keith Matassa, Mendy Garron, Padraig J. Duignan, Todd Schmitt, Tracey Goldstein, Morten Tryland
Publikováno v:
Frontiers in Veterinary Science, Vol 8 (2021)
Parapoxviruses cause nodular lesions on the skin and mucosal membranes of pinnipeds and infections by these viruses have been documented worldwide. Seal parapoxvirus is currently classified as a tentative species of the Parapoxvirus genus. Tissue or
Externí odkaz:
https://doaj.org/article/45f6a3a9e7944e4481c6a1a96083b8db
Autor:
Eunice Macedo, Sofia Almeida Santos, Alexandra Oliveira Doroftei, Helena Costa Araújo, Cosmin Nada
Publikováno v:
Educatio Siglo XXI, Vol 38, Iss 2 Jul-Oct (2020)
Este artículo se centra en la participación de jóvenes, como dimensión crucial de su ciudadanía, en el contexto educativo, después de casi veinte años del reconocimiento de la juventud como grupo social distinto de los niños, en la Unión Eur
Externí odkaz:
https://doaj.org/article/79a2a76808ae46439733e0af71f58c1f
Autor:
Amine Meliani, Florence Boisgerault, Romain Hardet, Solenne Marmier, Fanny Collaud, Giuseppe Ronzitti, Christian Leborgne, Helena Costa Verdera, Marcelo Simon Sola, Severine Charles, Alban Vignaud, Laetitia van Wittenberghe, Giorgia Manni, Olivier Christophe, Francesca Fallarino, Christopher Roy, Alicia Michaud, Petr Ilyinskii, Takashi Kei Kishimoto, Federico Mingozzi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Immunogenicity of AAV vectors renders repeated AAV dosing ineffective. Here the authors show that coadministration of nanoparticle-encapsulated rapamycin overcomes AAV immunogenicity through Treg induction, enabling efficient AAV redosing in mice and
Externí odkaz:
https://doaj.org/article/8c201057906f4f2d8d990ffb8e12cbae