Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Helena Cirule"'
Autor:
Laura Andze, Sanita Vitolina, Rudolfs Berzins, Janis Rizikovs, Daniela Godina, Arturs Teresko, Solveiga Grinberga, Eduards Sevostjanovs, Helena Cirule, Edgars Liepinsh, Aigars Paze
Publikováno v:
Plants, Vol 13, Iss 1, p 145 (2024)
Birch outer bark extract (BBE), containing pentacyclic triterpenes such as betulin, lupeol, and betulinic acid, is a widely recognized natural product renowned for its diverse pharmacological effects. However, its limited water solubility restricts i
Externí odkaz:
https://doaj.org/article/f4052903aace41e793b0c1165ca05bf9
Autor:
Melita Videja, Reinis Vilskersts, Stanislava Korzh, Helena Cirule, Eduards Sevostjanovs, Maija Dambrova, Marina Makrecka-Kuka
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Aim: Trimethylamine N-oxide (TMAO) is a gut microbiota-derived metabolite synthesized in host organisms from specific food constituents, such as choline, carnitine and betaine. During the last decade, elevated TMAO levels have been proposed as biomar
Externí odkaz:
https://doaj.org/article/89db9a47281647e781bcbd5a1abcb0aa
Autor:
Reinis Vilskersts, Karlis Vilks, Melita Videja, Helena Cirule, Olga Zharkova‐Malkova, Eduards Sevostjanovs, Maija Dambrova, Edgars Liepinsh
Publikováno v:
Physiological Reports, Vol 8, Iss 22, Pp n/a-n/a (2020)
Abstract Many drug candidates have shown significant renoprotective effects in preclinical models; however, there is no clinically used effective pharmacotherapy for acute kidney injury. The failure to translate from bench to bedside could be due to
Externí odkaz:
https://doaj.org/article/2b45ca3e61b64f7abc67970127fbf3f1
Autor:
Reinis Vilskersts, Dana Kigitovica, Stanislava Korzh, Melita Videja, Karlis Vilks, Helena Cirule, Andris Skride, Marina Makrecka-Kuka, Edgars Liepinsh, Maija Dambrova
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 45 (2021)
Right ventricular (RV) and left ventricular (LV) dysfunction is common in a significant number of hospitalized coronavirus disease 2019 (COVID-19) patients. This study was conducted to assess whether the improved mitochondrial bioenergetics by cardio
Externí odkaz:
https://doaj.org/article/bfd2317c0fed4977b30cd4bdb3fd555b
Autor:
Reinis Vilskersts, Helena Cirule, Maija Dambrova, Karlis Vilks, Marina Makrecka-Kuka, Edgars Liepinsh, Stanislava Korzh
Publikováno v:
Shock. 52:e153-e162
Significant impairments in mitochondrial function are associated with the development of multi-organ failure in sepsis/endotoxaemia, but the data on the dynamics of simultaneous mitochondrial impairment in multiple organs are limited. The aim of this
Autor:
Edgars Liepinsh, Solveiga Grinberga, Karlis Vilks, Stanislava Korzh, Maija Dambrova, Helena Cirule, Marina Makrecka-Kuka, Janis Kuka, Eduards Sevostjanovs
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Long-chainω-3 polyunsaturated fatty acids (PUFAs) are known to induce cardiometabolic benefits, but the metabolic pathways of their biosynthesis ensuring sufficient bioavailability require further investigation. Here, we show that a pharmacological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e88c2a165b9c886f8e98a8fd3fec8c26
https://zenodo.org/record/7503401
https://zenodo.org/record/7503401
Autor:
Helena Cirule, Edgars Liepinsh, Janis Kuka, Maija Dambrova, Eduards Sevostjanovs, Solveiga Grinberga, Marina Makrecka-Kuka
Publikováno v:
Basic & Clinical Pharmacology & Toxicology
Ischaemia in the heart is accompanied by the accumulation of long-chain acylcarnitines (LCACs) which is one of the multiple factors that contribute to the ischaemia-reperfusion damage development. Long-term pre-treatment that decreases carnitine and
Autor:
M. Dambrova, Solveiga Grinberga, Andrejs Erglis, Helena Cirule, E. Liepinsh, E. Makarova, L. Bondare, M. Mazule, Gustavs Latkovskis, Dace Hartmane
Aims Trimethylamine-N-oxide (TMAO) is a novel cardiovascular risk marker. We explored the association of commonly used cardiovascular medications with TMAO levels in patients and validated the identified associations in mice. Methods Detailed history
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9393b2dcec07370f72385858ed2ccac
https://europepmc.org/articles/PMC6177719/
https://europepmc.org/articles/PMC6177719/
Autor:
Maija Dambrova, Kristine Volska, Marina Makrecka-Kuka, Eduards Sevostjanovs, Edgars Liepinsh, Solveiga Grinberga, Janis Kuka, Reinis Vilskersts, Elina Makarova, Helena Cirule
Publikováno v:
Vascular Pharmacology. 72:101-107
Objective The elevation of the levels of l -carnitine and its fatty acid esters, acylcarnitines, in tissue or plasma has been linked to the development of atherosclerosis. Recently, a potent inhibitor of l -carnitine biosynthesis and transport, methy
Autor:
Marina Makrecka-Kuka, Maija Dambrova, Einars Loza, Daina Lola, Osvalds Pugovics, Solveiga Grinberga, Helena Cirule, Ivars Kalvins, Edgars Liepinsh, Reinis Vilskersts, Elina Makarova, Janis Kuka
Publikováno v:
British Journal of Pharmacology. 172:1319-1332
Background and Purpose The important pathological consequences of ischaemic heart disease arise from the detrimental effects of the accumulation of long-chain acylcarnitines in the case of acute ischaemia-reperfusion. The aim of this study is to test