Zobrazeno 1 - 10
of 410
pro vyhledávání: '"Helena B Nader"'
Autor:
Enio Rodrigues Vasques, Jose Eduardo Monteiro Cunha, Ana Maria Mendonca Coelho, Sandra N Sampietre, Rosely Antunes Patzina, Emilio Elias Abdo, Helena B Nader, Ivarne L S Tersariol, Marcelo Andrade Lima, Carlos M G Godoy, Tiago Rodrigues, Eleazar Chaib, Luiz A C D'Albuquerque
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149630 (2016)
BACKGROUND:Ischemia and reperfusion (I/R) causes tissue damage and intracellular calcium levels are a factor of cell death. Sodium calcium exchanger (NCX) regulates calcium extrusion and Trisulfated Disaccharide (TD) acts on NCX decreasing intracellu
Externí odkaz:
https://doaj.org/article/b8453b9601ae4891914361a899b02458
Autor:
Rodrigo A Silva, Marcelly V Palladino, Renan P Cavalheiro, Daisy Machado, Bread L G Cruz, Edgar J Paredes-Gamero, Maria C C Gomes-Marcondes, Willian F Zambuzzi, Luciana Vasques, Helena B Nader, Ana Carolina S Souza, Giselle Z Justo
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119020 (2015)
Herein, we provide new contribution to the mechanisms involved in keratinocytes response to hyperosmotic shock showing, for the first time, the participation of Low Molecular Weight Protein Tyrosine Phosphatase (LMWPTP) activity in this event. We rep
Externí odkaz:
https://doaj.org/article/3b3e5dcb64e9404dbb4aa502dec41edd
Autor:
Yvette M Coulson-Thomas, Vivien J Coulson-Thomas, Andrew L Norton, Tarsis F Gesteira, Renan P Cavalheiro, Maria Cecília Z Meneghetti, João R Martins, Ronald A Dixon, Helena B Nader
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131105 (2015)
Bone tissue is mineralized dense connective tissue consisting mainly of a mineral component (hydroxyapatite) and an organic matrix comprised of collagens, non-collagenous proteins and proteoglycans (PGs). Extracellular matrix proteins and PGs bind ti
Externí odkaz:
https://doaj.org/article/192ae43964a241feba43ae37077aac0b
Autor:
Igor Z Damasceno, Katia R B Melo, Fabio D Nascimento, Daianne S P Souza, Mariana S Araujo, Sinval E G Souza, Misako U Sampaio, Helena B Nader, Ivarne L S Tersariol, Guacyara Motta
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121721 (2015)
Human H-kininogen (120 kDa) plays a role in many pathophysiological processes and interacts with the cell surface through protein receptors and proteoglycans, which mediate H-kininogen endocytosis. In the present work we demonstrate that H-kininogen
Externí odkaz:
https://doaj.org/article/554668a1b1414a4abc2c132bdbdbff8e
Autor:
Camila Lopes Veronez, Fabio D Nascimento, Katia R B Melo, Helena B Nader, Ivarne L S Tersariol, Guacyara Motta
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91280 (2014)
INTRODUCTION: The aim of this work was to evaluate the role of human plasma prekallikrein assembly and processing in cells and to determine whether proteoglycans, along with high molecular weight kininogen (H-kininogen), influence this interaction. M
Externí odkaz:
https://doaj.org/article/2b08a626812f4c0298dd19912d991caa
Autor:
Bruna Ribeiro Carneiro, Paulo Castanho A Pernambuco Filho, Ana Paula de Sousa Mesquita, Douglas Santos da Silva, Maria Aparecida S Pinhal, Helena B Nader, Carla Cristina Lopes
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e116001 (2014)
Anoikis is a programmed cell death induced upon cell detachment from extracellular matrix, behaving as a critical mechanism in preventing adherent-independent cell growth and attachment to an inappropriate matrix, thus avoiding colonization of distan
Externí odkaz:
https://doaj.org/article/6820c3fb0b304614a66da6dfda4d48b2
Autor:
Tarsis F Gesteira, Laércio Pol-Fachin, Vivien Jane Coulson-Thomas, Marcelo A Lima, Hugo Verli, Helena B Nader
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70880 (2013)
Sulfation patterns along glycosaminoglycan (GAG) chains dictate their functional role. The N-deacetylase N-sulfotransferase family (NDST) catalyzes the initial downstream modification of heparan sulfate and heparin chains by removing acetyl groups fr
Externí odkaz:
https://doaj.org/article/39b72c7abf2e4ffdbcd1def2c9a3490c
Autor:
Gabriel L C Nunes, Alyne Simões, Fábio H Dyszy, Claudio S Shida, Maria A Juliano, Luiz Juliano, Tarsis F Gesteira, Helena B Nader, Gillian Murphy, Alain F Chaffotte, Michel E Goldberg, Ivarne L S Tersariol, Paulo C Almeida
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21525 (2011)
Heparin has been shown to regulate human neutrophil elastase (HNE) activity. We have assessed the regulatory effect of heparin on Tissue Inhibitor of Metalloproteases-1 [TIMP-1] hydrolysis by HNE employing the recombinant form of TIMP-1 and correlate
Externí odkaz:
https://doaj.org/article/afc48b67b6e64ee1ad314b993234f385
Autor:
Marcelo A Lima, Timothy R Rudd, Eduardo H C de Farias, Lyvia F Ebner, Tarsis F Gesteira, Lauro M de Souza, Aline Mendes, Carolina R Córdula, João R M Martins, Debra Hoppensteadt, Jawed Fareed, Guilherme L Sassaki, Edwin A Yates, Ivarne L S Tersariol, Helena B Nader
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e15970 (2011)
The year 2007 was marked by widespread adverse clinical responses to heparin use, leading to a global recall of potentially affected heparin batches in 2008. Several analytical methods have since been developed to detect impurities in heparin prepara
Externí odkaz:
https://doaj.org/article/0cf46850f38c422ab2f93e0aadc77874
Autor:
Luiz Guilherme S. Lenzi, João Baptista Gomes dos Santos, Renan P. Cavalheiro, Aline Mendes, Elsa Y. Kobayashi, Helena B. Nader, Flavio Faloppa
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7192 (2024)
Dupuytren’s disease (DD) is a prevalent fibroproliferative disorder of the hand, shaped by genetic, epigenetic, and environmental influences. The extracellular matrix (ECM) is a complex assembly of diverse macromolecules. Alterations in the ECM’s
Externí odkaz:
https://doaj.org/article/6ad4b9e6280748e2830575e7acee0315