Výsledky vyhledávání - "Helena Dračínská"

Autor: Helena, Dračínská, Radek, Indra, Sandra, Jelínková, Věra, Černá, Volker Manfred, Arlt, Marie, Stiborová

Publikováno v: International Journal of Molecular Sciences

The environmental pollutant benzo[a]pyrene (BaP) is a human carcinogen that reacts with DNA after metabolic activation catalysed by cytochromes P450 (CYP) 1A1 and 1B1 together with microsomal epoxide hydrolase. The azo dye Sudan I is a potent inducer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d7cc779edaada5ce6997744b3833c431
https://pubmed.ncbi.nlm.nih.gov/34360828

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Photo-initiated crosslinking extends mapping of the protein–protein interface to membrane-embedded portions of cytochromes P450 2B4 and b5

Autor: Tomáš Ječmen, Marie Stiborová, Petr Hodek, Věra Černá, Renata Ptáčková, Miroslav Šulc, Helena Dračínská, Jiří Hudeček

Publikováno v: Methods. 89:128-137

Protein-protein interactions play a central role in the regulation of many biochemical processes (e.g. the system participating in enzyme catalysis). Therefore, a deeper understanding of protein-protein interactions may contribute to the elucidation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::255a068a3bfebb18c76340935a5b20b0
https://doi.org/10.1016/j.ymeth.2015.07.015

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Induced Expression of Cytochrome P450 1A and NAD(P)H:Quinone Oxidoreductase Determined at mRNA, Protein, and Enzyme Activity Levels in Rats Exposed to the Carcinogenic Azo Dye 1-Phenylazo-2-naphthol (Sudan I)

Autor: Jaroslav Brotanek, Dagmar Svášková, Marie Stiborová, Václav Martínek, Jan Milichovský, Heinz H. Schmeiser, Petr Hodek, Eva Frei, Helena Dračínská, Žaneta Hejduková

Publikováno v: Chemical Research in Toxicology. 26:290-299

Sudan I (1-phenylazo-2-hydroxynaphthol) is a suspected human carcinogen causing tumors in the livers and urinary bladders of rats, mice, and rabbits. Here, we investigated for the first time the influence of Sudan I exposure on the expression of seve

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https://doi.org/10.1021/tx3004533

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Induction of biotransformation enzymes by the carcinogenic air-pollutant 3-nitrobenzanthrone in liver, kidney and lung, after intra-tracheal instillation in rats

Autor: Volker M. Arlt, Marie Stiborová, Eva Frei, Helena Dračínská, Jana Mizerovská, Heinz H. Schmeiser

Publikováno v: Mizerovska, J, Dracinska, H, Frei, E, Schmeiser, H H, Arlt, V M & Stiborova, M 2011, ' Induction of biotransformation enzymes by the carcinogenic air-pollutant 3-nitrobenzanthrone in liver, kidney and lung, after intra-tracheal instillation in rats ', Mutation Research-Genetic Toxicology And Environmental Mutagenesis, vol. 720, no. 1-2, pp. 34-41 . https://doi.org/10.1016/j.mrgentox.2010.12.003

3-Nitrobenzanthrone (3-NBA), a carcinogenic air pollutant, was investigated for its ability to induce cytochrome P450 (CYP) 1A1/2 and NAD(P)H:quinone oxidoreductase (NQO1) in liver, kidney and lung of rats treated by intra-tracheal instillation. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d8892d0a63bd7476e3a3cb894fb993
https://doi.org/10.1016/j.mrgentox.2010.12.003

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3-Aminobenzanthrone, a human metabolite of the carcinogenic environmental pollutant 3-nitrobenzanthrone, induces biotransformation enzymes in rat kidney and lung

Autor: Volker M. Arlt, David H. Phillips, Petr Hodek, Marketa Martinkova, Jiří Liberda, Marie Stiborová, Eva Frei, Helena Dračínská, Jana Mizerovská, Heinz H. Schmeiser, Jiří Hudeček

Publikováno v: Stiborova, M, Dracinska, H, Martinkova, M, Mizerovska, J, Hudecek, J, Hodek, P, Liberda, J, Frei, E, Schmeiser, H H, Phillips, D & Arlt, V 2009, ' 3-Aminobenzanthrone, a human metabolite of the carcinogenic environmental pollutant 3-nitrobenzanthrone, induces biotransformation enzymes in rat kidney and lung ', Mutation Research-Genetic Toxicology And Environmental Mutagenesis, vol. 676, no. 1-2, pp. 93-101 . https://doi.org/10.1016/j.mrgentox.2009.04.013

3-aminobenzanthrone (3-ABA) is the metabolite of the carcinogenic air pollutant 3-nitrobenzanthrone (3-NBA). 3-ABA was investigated for its ability to induce cytochrome P450 1A1 (CYP1A1) and NAD(P)H:quinone oxidoreductase (NQO1) in kidney and lung of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a67f8961893975ce4bbf6a7d8d3dd1f
https://doi.org/10.1016/j.mrgentox.2009.04.013

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Cytochrome P450-mediated metabolism of N-(2-methoxyphenyl)-hydroxylamine, a human metabolite of the environmental pollutants and carcinogens o-anisidine and o-nitroanisole

Autor: Václav Martínek, Karel Naiman, Martin Dračínský, Marketa Martinkova, Marie Stiborová, Martin Štícha, Petr Hodek, Eva Frei, Helena Dračínská

Publikováno v: Interdisciplinary Toxicology

Cytochrome P450-mediated metabolism ofN-(2-methoxyphenyl)-hydroxylamine, a human metabolite of the environmental pollutants and carcinogenso-anisidine ando-nitroanisoleN-(2-methoxyphenyl)hydroxylamine is a human metabolite of the industrial and envir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8c3b50c02ddd4e46561685b81661d6
https://doi.org/10.2478/v10102-010-0045-8

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Oxidation of carcinogenic 2-nitroanisole by rat cytochromes P450 - similarity between human and rat enzymes

Autor: Marie Stiborová, Marketa Martinkova, Petr Hodek, Eva Frei, Helena Dračínská, Jiří Hudeček, Martina Svobodová

Publikováno v: Interdisciplinary Toxicology

Oxidation of carcinogenic 2-nitroanisole by rat cytochromes P450 - similarity between human and rat enzymes2-Nitroanisole (2-NA) is an important industrial pollutant and a potent carcinogen for rodents. Understanding which cytochrome P450 (CYP) enzym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51687be72a3cf086cff5f8beea1020e4
https://doi.org/10.2478/v10102-010-0035-x

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Redox Cycling in the Metabolism of the Environmental Pollutant and Suspected Human Carcinogen o-Anisidine by Rat and Rabbit Hepatic Microsomes

Autor: Martin Dračínský, Jirí Liberda, Marie Stiborová, Miroslav Šulc, Eva Frei, Helena Dračínská, Jirí Hudeček, Petr Hodek, Marketa Martinkova, Lucie Kejíková, Heinz H. Schmeiser, Karel Naiman

Publikováno v: Chemical Research in Toxicology. 21:1610-1621

We investigated the ability of hepatic microsomes from rat and rabbit to metabolize 2-methoxyaniline (o-anisidine), an industrial and environmental pollutant and a bladder carcinogen for rodents. Using HPLC combined with electrospray tandem mass spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89de05c99779c177e0168c3c6ddc3ee
https://doi.org/10.1021/tx8001127

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The Anticancer Drug Ellipticine is an Inducer of Rat NAD(P)H:Quinone Oxidoreductase

Autor: Marie Stiborová, Petr Hodek, Dagmar Aimová, Eva Frei, Helena Dračínská, Jiří Hudeček, Helena Ryšlavá, Heinz H. Schmeiser

Publikováno v: Collection of Czechoslovak Chemical Communications. 72:1350-1364

The antineoplastic agent ellipticine was investigated for its ability to induce the biotransformation enzyme NAD(P)H:quinone oxidoreductase (DT-diaphorase, EC 1.6.99.2) in male Wistar rats. Using the real-time polymerase chain reaction, the levels of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3bc10257143653e1224c5f23f2827864
https://doi.org/10.1135/cccc20071350

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