Zobrazeno 1 - 10 of 97 pro vyhledávání: '"Helena, Geys"'
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Akademický článek
Development of a new hazard scoring system in primary neuronal cell cultures for drug-induced acute neuronal toxicity identification in early drug discovery
Autor: Mohamed Kreir, Dea Putri, Fetene Tekle, Francesca Pibiri, Constantin d’Ydewalle, Karel Van Ammel, Helena Geys, Ard Teisman, David J. Gallacher, Hua Rong Lu
Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)
We investigated drug-induced acute neuronal electrophysiological changes using Micro-Electrode arrays (MEA) to rat primary neuronal cell cultures. Data based on 6-key MEA parameters were analyzed for plate-to-plate vehicle variability, effects of pos
Externí odkaz: https://doaj.org/article/6519f93f4908451c87b4f64f1cc25244
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4
Bayesian pooling versus sequential integration of small preclinical trials: a comparison within linear and nonlinear modeling frameworks
Autor: Helena Geys, Tom Jacobs, Fabiola La Gamba, Christel Faes, Jan Serroyen
Publikováno v: Journal of Biopharmaceutical Statistics. 31:25-36
Bayesian sequential integration is an appealing approach in drug development, as it allows to recursively update posterior distributions as soon as new data become available, thus considerably reducing the computation time. However, preclinical trial
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba4ecfa92d390835640033a2f03e14f7
https://doi.org/10.1080/10543406.2020.1776312
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5
The Impact of Experimental and Calculated Error on the Performance of Affinity Predictions
Autor: Gary Tresadern, Kanaka Tatikola, Javier Cabrera, Lingle Wang, Robert Abel, Herman van Vlijmen, Helena Geys
Publikováno v: Journal of chemical information and modeling. 62(3)
The accurate prediction of binding affinity between protein and small molecules with free energy methods, particularly the difference in binding affinities via relative binding free energy calculations, has undergone a dramatic increase in use and im
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::211a24f6454f3eea6d6d5b2e33eebac2
https://pubmed.ncbi.nlm.nih.gov/35061383
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6
Methods for Non-Compartmental Pharmacokinetic Analysis With Observations Below the Limit of Quantification
Autor: Thomas Jaki, Helen Yvette Barnett, Helena Geys, Tom Jacobs
Pharmacokinetic (PK) studies are conducted to learn about the absorption, distribution, metabolism, and excretion processes of an externally administered compound by measuring its concentration in bodily tissue at a number of time points after admini
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc6c8f7b94abe88e71ca358df632ad1a
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7
A Bayesian K-PD model for synergy: A case study
Autor: Christel Faes, Fabiola La Gamba, Helena Geys, Tom Jacobs, Luc Ver Donck
Publikováno v: Pharmaceutical Statistics
Coadministration of 2 or more compounds can alter both the pharmacokinetics and pharmacodynamics of individual compounds. While experiments on pharmacodynamic drug-drug interactions are usually performed in an in vitro setting, this experiment focuse
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99863c042255f2f8790e0076f6f7afd0
https://doi.org/10.1002/pst.1887
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9
Comparing sampling methods for pharmacokinetic studies using model averaged derived parameters
Autor: Helena Geys, Thomas Jaki, Tom Jacobs, Helen Yvette Barnett
Publikováno v: Statistics in Medicine. 36:4301-4315
Pharmacokinetic studies aim to study how a compound is absorbed, distributed, metabolised, and excreted. The concentration of the compound in the blood or plasma is measured at different time points after administration and pharmacokinetic parameters
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c63b4453bd6248f0b22ba8fc4001f2
https://doi.org/10.1002/sim.7436
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10
Testing of acetaminophen in support of the international multilaboratory in vivo rat Pig-a assay validation trial
Autor: Kathleen De Vlieger, Ann Schuermans, Bas-jan van der Leede, Helena Geys, Marjolein van Heerden, Sandra De Jonghe, Terry Van Doninck, Fetene Tekle, Jacky Van Gompel, Sandy Weiner
Publikováno v: Environmental and Molecular Mutagenesis
Acetaminophen, a nonmutagenic compound as previously concluded from bacteria, in vitro mammalian cell, and in vivo transgenic rat assays, presented a good profile as a nonmutagenic reference compound for use in the international multilaboratory Pig
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b1bc3f3b77f93d67798463dd79a510
https://pubmed.ncbi.nlm.nih.gov/32187737
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