Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Helena, Dzojic"'
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e14700 (2011)
The histone deacetylase inhibitor FK228 has previously been shown to enhance adenoviral transgene expression when cells are pre-incubated with the drug. Upregulation of the coxsackie adenovirus receptor (CAR), leading to increased viral transduction,
Externí odkaz:
https://doaj.org/article/ff59be40d7c8422cbece563a9e614932
Autor:
Helena Dzojic, Sofia Vikman, Christina Ninalga, Angelica Loskog, Thomas H. Tötterman, Magnus Essand, Olle Korsgren
Publikováno v:
Europe PubMed Central
Scopus-Elsevier
Scopus-Elsevier
Tumors exhibit immune escape properties that promote their survival. These properties include modulation of Ag presentation, secretion of immunosuppressive factors, resistance to apoptosis, and induction of immune deviation, e.g., shifting from Th1-
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 2, p e14700 (2011)
PLoS ONE, Vol 6, Iss 2, p e14700 (2011)
The histone deacetylase inhibitor FK228 has previously been shown to enhance adenoviral transgene expression when cells are pre-incubated with the drug. Upregulation of the coxsackie adenovirus receptor (CAR), leading to increased viral transduction,
Autor:
Ellen, Schenk, Magnus, Essand, Chris H, Bangma, Chris, Barber, Jean-Paul, Behr, Simon, Briggs, Robert, Carlisle, Wing-Shing, Cheng, Angelika, Danielsson, Iris J C, Dautzenberg, Helena, Dzojic, Patrick, Erbacher, Kerry, Fisher, April, Frazier, Lindsay J, Georgopoulos, Rob, Hoeben, Stefan, Kochanek, Daniela, Koppers-Lalic, Robert, Kraaij, Florian, Kreppel, Leif, Lindholm, Maria, Magnusson, Norman, Maitland, Patrick, Neuberg, Berith, Nilsson, Manfred, Ogris, Jean-Serge, Remy, Michelle, Scaife, Erik, Schooten, Len, Seymour, Thomas, Totterman, Taco G, Uil, Karel, Ulbrich, Joke L M, Veldhoven-Zweistra, Jeroen, de Vrij, Wytske, van Weerden, Ernst, Wagner, Ralph, Willemsen
Publikováno v:
Human gene therapy. 21(7)
Prostate cancer is at present the most common malignancy in men in the Western world. When localized to the prostate, this disease can be treated by curative therapy such as surgery and radiotherapy. However, a substantial number of patients experien
Publikováno v:
Cancer gene therapy. 15(4)
Conditionally replicating adenoviruses are developing as a complement to traditional cancer therapies. Ad[I/PPT-E1A] is an E1B/E3-deleted virus that replicates exclusively in prostate cells, since the expression of E1A is controlled by the recombinan
Autor:
Justyna Leja, Magnus Essand, Kjell Öberg, Elisabet Gustafson, Valeria Giandomenico, Helena Dzojic
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 13(8)
Purpose: The use of replication-selective oncolytic adenoviruses is an emerging therapeutic approach for cancer, which thus far has not been employed for carcinoids. We therefore constructed Ad[CgA-E1A], a novel replication-selective oncolytic adenov
Publikováno v:
Cancer gene therapy. 14(3)
The recombinant prostate-specific PPT sequence comprises a prostate-specific antigen enhancer, a PSMA enhancer and a TARP promoter. It is transcriptionally active in human prostate cancer cells both in the presence and absence of testosterone. Howeve
Publikováno v:
The Prostate. 66(8)
Ligation of CD40 by its ligand (CD40L) can generate a variety of responses depending on the cell types that express CD40. The interaction between CD40L and CD40 on antigen presenting cells is essential for the initiation of antigen specific T cell re
Publikováno v:
Molecular Therapy. 13
Conditionally replicating adenoviruses are developing as a complement to traditional cancer therapies. Ad[I/PPT-E1A] is a virus that replicates exclusively in prostate cells since the expression of E1A is controlled by the tissue specific promoter PP
Publikováno v:
Molecular Therapy. 13