Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Helena, Ahlfors"'
Autor:
Helena Ahlfors, Nneka Anyanwu, Edvinas Pakanavicius, Natalia Dinischiotu, Eva Lana-Elola, Sheona Watson-Scales, Justin Tosh, Frances Wiseman, James Briscoe, Karen Page, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Gene expression dysregulation domains (GEDDs) have been reported in Down syndrome (DS) cells, where changes in gene expression are clustered. Here the authors find that, while GEDDs are present in DS cells and in the Dp1Tyb mouse model of DS, GEDDs d
Externí odkaz:
https://doaj.org/article/d58c59e260be485db688012547887273
Autor:
Terhi Ruohtula, Anita Kondrashova, Jussi Lehtonen, Sami Oikarinen, Anu-Maaria Hämäläinen, Onni Niemelä, Aleksandr Peet, Vallo Tillmann, Janne K. Nieminen, Jorma Ilonen, Mikael Knip, Outi Vaarala, Heikki Hyöty, the DIABIMMUNE Study Group, Taina Härkönen, Samppa Ryhänen, Heli Siljander, Katriina Koski, Matti Koski, Janne Nieminen, Anne Ormisson, Valentina Ulich, Elena Kuzmicheva, Sergei Mokurov, Svetlana Markova, Svetlana Pylova, Marina Isakova, Elena Shakurova, Vladimir Petrov, Natalya V. Dorshakova, Tatyana Karapetyan, Tatyana Varlamova, Minna Kiviniemi, Kristi Alnek, Helis Janson, Raivo Uibo, Tiit Salum, Erika von Mutius, Juliane Weber, Helena Ahlfors, Henna Kallionpää, Essi Laajala, Riitta Lahesmaa, Harri Lähdesmäki, Robert Moulder, Hanna Honkanen, Hermie J. M. Harmsen, Marcus C. De Goffau, Gjalt Welling, Kirsi Alahuhta, Suvi M. Virtanen
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Early childhood infections have been implicated in the development of immune-mediated diseases, such as allergies, asthma, and type 1 diabetes. We set out to investigate the immunomodulatory effects of early viral infections experienced before the ag
Externí odkaz:
https://doaj.org/article/ca21e7c29d554bd19737315e49f69bb8
Autor:
Matteo Villa, Stefania Crotta, Kevin S. Dingwell, Elizabeth M. A. Hirst, Manolis Gialitakis, Helena Ahlfors, James C. Smith, Brigitta Stockinger, Andreas Wack
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Epithelia are barriers against environmental insults and express the transcription factor aryl hydrocarbon receptor (AhR). Here the authors show that AhR regulates multiciliogenesis via cyclin O and Multicilin in a Notch-dependent manner and that thi
Externí odkaz:
https://doaj.org/article/2586c152044d48ffa6ee83a3bf1f6f6c
Autor:
Ebun Omoyinmi, Ariane Standing, Annette Keylock, Fiona Price-Kuehne, Sonia Melo Gomes, Dorota Rowczenio, Sira Nanthapisal, Thomas Cullup, Rodney Nyanhete, Emma Ashton, Claire Murphy, Megan Clarke, Helena Ahlfors, Lucy Jenkins, Kimberly Gilmour, Despina Eleftheriou, Helen J Lachmann, Philip N Hawkins, Nigel Klein, Paul A Brogan
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181874 (2017)
Monogenic autoinflammatory diseases (AID) are a rapidly expanding group of genetically diverse but phenotypically overlapping systemic inflammatory disorders associated with dysregulated innate immunity. They cause significant morbidity, mortality an
Externí odkaz:
https://doaj.org/article/af04bb63bbd945f089230fb731d184d5
Autor:
Helen Spencer, Stephen D. Marks, Lyn S. Chitty, Natalie Chandler, Evgenia Preka, Matthew Fenton, Helena Ahlfors, Drew Ellershaw
Publikováno v:
Clinical chemistry, 66(10), 1300-1309. American Association for Clinical Chemistry Inc.
Background The use of cell-free DNA (cfDNA) as a noninvasive biomarker to detect allograft damage is expanding rapidly. However, quantifying the low fraction of donor-derived cfDNA (ddcfDNA) is challenging and requires a highly sensitive technique. d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d117432694e2526fc35456dfdb0d232
https://doi.org/10.1093/clinchem/hvaa173
https://doi.org/10.1093/clinchem/hvaa173
Autor:
Harri Lähdesmäki, Helena Ahlfors, Henrik Mannerström, Michele Vantini, Brigitta Stockinger, Sini Rautio
Publisher Copyright: © 2022 High-throughput technologies produce gene expression time-series data that need fast and specialized algorithms to be processed. While current methods already deal with different aspects, such as the non-stationarity of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac994c6834b215aec0291355e3a017fa
Publikováno v:
Molecular Systems Biology, Vol 3, Iss 1, Pp 1-17 (2007)
Abstract We examined responses of the B‐cell antigen receptor‐dependent intracellular signaling network to targeted perturbations induced through siRNA‐mediated depletion of select signaling intermediates. The constituent nodes displayed graded
Externí odkaz:
https://doaj.org/article/2fb81ff6a09b48daa4df6d7c628c79a4
Autor:
Emma Wakeling, Quan Li, Laurence E. Walsh, Maria J. Guillen Sacoto, Julie Vogt, Jeff L. Waugh, James R. Lupski, Elizabeth E. Palmer, Alan F. Rope, Robert Kleyner, Amalia Mallawaarachchi, Sebastian Lunke, Jennifer E. Posey, Pankaj B. Agrawal, Sebastien Moutton, Laurence Faivre, Zornitza Stark, Prosper Lukusa, Emily Fassi, Gareth Baynam, Gabriela Soares, Antonie D. Kline, Sonja A. de Munnik, Sarah A. Sandaradura, Chunhua Weng, Lucinda Murray, Lisa Ewans, Ganka Douglas, Eyby Leon, Shehla Mohammed, Marcia C. Willing, Elaine Marchi, Nora Alexander, Paul R. Mark, Joris Vermeesch, Lauren Dreyer, Aimé Lumaka, Koenraad Devriendt, Gholson J. Lyon, Helena Ahlfors, Katelyn Payne, Piatek G. Stefan, Jullianne Diaz, Lesley C. Adès, Simona Capponi, Jean-Baptiste Rivière, Michael F. Buckley, Amber Begtrup, H. T. Marc Timmers, Tony Roscioli, Mengge Zhao, Ana R. Gonçalves, Hanyin Cheng, Lisa Worgan, Kai Wang, Jorge Oliveira
Publikováno v:
Hum Mutat
We recently described a new neurodevelopmental syndrome (TAF1/MRXS33 intellectual disability syndrome) (MIM# 300966) caused by pathogenic variants involving the X-linked gene TAF1, which participates in RNA polymerase II transcription. The initial st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b085cf5ac7f21229d6b3096c675267c4
https://doi.org/10.1002/humu.23936
https://doi.org/10.1002/humu.23936
Autor:
Tommaso B. Jannini, Vijay Tailor, Ken K. Nischal, Rodney Nyanhete, Lily Islam, Helena Ahlfors, Maria Bitner-Glindzicz, Mario Zanolli, John Brookes, Camila Gabriel, Thomas Cullup, Mariya Moosajee, Lucy Jenkins, Peng T. Khaw, Robert H. Henderson, Aara Patel, Jane Hayward, Annegret Dahlmann-Noor, Maria Papadopoulos, Leonardo E Valdivia, Jane A. Hurst, Yassir Abbou-Rayyah, Jane C. Sowden
Publikováno v:
Ophthalmology. 126:888-907
Purpose To develop a comprehensive next-generation sequencing panel assay that screens genes known to cause developmental eye disorders and inherited eye disease and to evaluate its diagnostic yield in a pediatric cohort with malformations of the glo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c9daa2bded40b3fbda0cba928be46f0
https://doi.org/10.1016/j.ophtha.2018.12.050
https://doi.org/10.1016/j.ophtha.2018.12.050
Autor:
Lingjia Kong, Soile Tuomela, Lauri Hahne, Helena Ahlfors, Olli Yli-Harja, Bengt Fadeel, Riitta Lahesmaa, Reija Autio
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68414 (2013)
The potential impact of nanoparticles on the environment and on human health has attracted considerable interest worldwide. The amount of transcriptomics data, in which tissues and cell lines are exposed to nanoparticles, increases year by year. In a
Externí odkaz:
https://doaj.org/article/d5b8280371664bccb51724e1c495bc8b