Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Helena, Öhrvik"'
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Mast cells (MCs) are characterized by an abundance of lysosome-like secretory granules filled with immunomodulatory compounds including histamine, cytokines, lysosomal hydrolases, MC-restricted proteases, and serglycin proteoglycans. The latter are e
Externí odkaz:
https://doaj.org/article/54985c78d2d24ff9b12530582d7c76c4
Publikováno v:
Genetic Engineering & Biotechnology News. 38:S30-S32, S34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0af5ccb66986e74157e0dcf2e9688145
https://doi.org/10.1089/gen.38.15.17
https://doi.org/10.1089/gen.38.15.17
Publikováno v:
Journal of Biological Chemistry. 291:13905-13916
Copper is an essential metal ion for embryonic development, iron acquisition, cardiac function, neuropeptide biogenesis, and other critical physiological processes. Ctr1 is a high affinity Cu(+) transporter on the plasma membrane and endosomes that e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f53e2513bdd3e975ec8b19044a27d039
https://doi.org/10.1074/jbc.m116.731281
https://doi.org/10.1074/jbc.m116.731281
Autor:
Madeleine Rådinger, B. van Anrooij, O. Klein, Helena Öhrvik, G. Ainooson, A. Tobio, Ulrich Blank, T. Stefanache, Yingxin Yu, Jenny Hallgren, R. Torres, J. Grootens, Magnus Åbrink, F. Ngo-Nyekel, Aida Paivandy, E. Serrano-Candelas, B. Dema, Bettina M. Jensen, S. Cohen-Mor, Lars Hellman, Maya Salomonsson, H. K. Gura, Marcus Maurer, M. Campbell, Marios Stylianou, V. G. Pavlova, M. Bambouskova, C. G. Rose, Nicolas Charles
Publikováno v:
Scandinavian journal of immunology, 83(6), 465-472. Wiley-Blackwell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f286ecf0002b69592933da0699a79d5
https://research.rug.nl/en/publications/089e01f2-0ef5-4c77-a503-b614e3994348
https://research.rug.nl/en/publications/089e01f2-0ef5-4c77-a503-b614e3994348
Autor:
Brandon L. Logeman, Gunnar Pejler, Dennis J. Thiele, Helena Öhrvik, Glyn Noguchi, Inger Eriksson, Lena Kjellén
Publikováno v:
The Journal of Immunology. 195:3654-3664
Copper (Cu) is essential for multiple cellular functions. Cellular uptake of Cu+ is carried out by the Ctr1 high-affinity Cu transporter. The mobilization of endosomal Cu pools is regulated by a protein structurally similar to Ctr1, called Ctr2. It w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2318d93ac0da0a8748ef3267588ef2
https://doi.org/10.4049/jimmunol.1500283
https://doi.org/10.4049/jimmunol.1500283
Autor:
Helena Öhrvik, Dennis J. Thiele
Publikováno v:
Journal of Trace Elements in Medicine and Biology. 31:178-182
Copper (Cu) is an essential metal for growth and development that has the potential to be toxic if levels accumulate beyond the ability of cells to homeostatically balance uptake with detoxification. One system for Cu acquisition is the integral memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce29d613d394dda3938bec40a08ff59
https://doi.org/10.1016/j.jtemb.2014.03.006
https://doi.org/10.1016/j.jtemb.2014.03.006
Publikováno v:
Metallomics : integrated biometal science. 9(9)
A general principle in all cells in the body is that an essential metal - here copper - is taken up at the plasma membrane, directed through cellular compartments for use in specific enzymes and pathways, stored in specific scavenging molecules if in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482b1a8281e939ae94df6812e8ed4359
https://pubmed.ncbi.nlm.nih.gov/28685789
https://pubmed.ncbi.nlm.nih.gov/28685789
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 199(12)
Copper has previously been implicated in the regulation of immune responses, but the impact of this metal on mast cells is poorly understood. In this article, we address this issue and show that copper starvation of mast cells causes increased granul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b188f4c69effb870d6bd648c57fa8b8
https://pubmed.ncbi.nlm.nih.gov/29127151
https://pubmed.ncbi.nlm.nih.gov/29127151
Publikováno v:
Cell Death & Disease
It has been recognized for a long time that the secretory granules of mast cells are acidic, but the functional importance of maintaining an acidic pH in the mast cell granules is not fully understood. Here we addressed this issue by examining the ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::13dd9a9e25eb412429a679e9fd743ae8
https://pubmed.ncbi.nlm.nih.gov/28492555
https://pubmed.ncbi.nlm.nih.gov/28492555
Autor:
Dennis J. Thiele, Helena Öhrvik
Publikováno v:
Annals of the New York Academy of Sciences. 1314:32-41
The copper transporter 1, Ctr1, is part of a major pathway for cellular copper (Cu) uptake in the intestinal epithelium, in hepatic and cardiac tissue, and likely in many other mammalian cells and tissues. Here, we summarize what is currently known a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b491d86a3269be906dd66d4412da7b9
https://doi.org/10.1111/nyas.12371
https://doi.org/10.1111/nyas.12371