Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Helen Wedegaertner"'
1
Akademický článek
Endothelial APC/PAR1 distinctly regulates cytokine-induced pro-inflammatory VCAM-1 expression
Autor: Cierra A. Birch, Helen Wedegaertner, Lennis B. Orduña-Castillo, Monica L. Gonzalez Ramirez, Huaping Qin, JoAnn Trejo
Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2023)
Introduction: Dysfunction of the endothelium impairs its’ protective role and promotes inflammation and progression of vascular diseases. Activated Protein C (APC) elicits endothelial cytoprotective responses including barrier stabilization, anti-i
Externí odkaz: https://doaj.org/article/d9be02a8021e49b38514beaef6fa1af0
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2
Akademický článek
Interaction between the BAG1S isoform and HSP70 mediates the stability of anti-apoptotic proteins and the survival of osteosarcoma cells expressing oncogenic MYC
Autor: Victoria J. Gennaro, Helen Wedegaertner, Steven B. McMahon
Publikováno v: BMC Cancer, Vol 19, Iss 1, Pp 1-14 (2019)
Abstract Background The oncoprotein MYC has the dual capacity to drive cell cycle progression or induce apoptosis, depending on the cellular context. BAG1 was previously identified as a transcriptional target of MYC that functions as a critical deter
Externí odkaz: https://doaj.org/article/6b22ccd228454ba2acf8e16bbd46492c
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3
Divergent regulation of α-arrestin ARRDC3 function by ubiquitination
Autor: Helen Wedegaertner, Oye Bosompra, Irina Kufareva, JoAnn Trejo
Publikováno v: Molecular Biology of the Cell.
The α-arrestin ARRDC3 is a recently discovered tumor suppressor in invasive breast cancer that functions as a multi-faceted adaptor protein to control protein trafficking and cellular signaling. However, the molecular mechanisms which control ARRDC3
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce7352d85003e41fec869bf17c2e80c2
https://doi.org/10.1091/mbc.e23-02-0055
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4
The α-Arrestin ARRDC3 Is an Emerging Multifunctional Adaptor Protein in Cancer
Autor: Helen Wedegaertner, Wen-An Pan, David Gonzalez, Carlos C Gonzalez, JoAnn Trejo
Publikováno v: Antioxidants & redox signaling, vol 36, iss 13-15
Antioxid Redox Signal
SIGNIFICANCE: Adaptor proteins control the spatiotemporal dynamics of cellular signaling. Dysregulation of adaptor protein function can cause aberrant cell signaling and promote cancer. The arrestin family of adaptor proteins are known to regulate si
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7a70969af3ee3ab4b69bf06aa868c5
https://doi.org/10.1089/ars.2021.0193
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6
Interaction between the BAG1S isoform and HSP70 mediates the stability of anti-apoptotic proteins and the survival of osteosarcoma cells expressing oncogenic MYC
Autor: Steven B. McMahon, Helen Wedegaertner, Victoria J. Gennaro
Publikováno v: BMC Cancer, Vol 19, Iss 1, Pp 1-14 (2019)
BMC Cancer
Background The oncoprotein MYC has the dual capacity to drive cell cycle progression or induce apoptosis, depending on the cellular context. BAG1 was previously identified as a transcriptional target of MYC that functions as a critical determinant of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fde64a2be0fe1220bc42d324e2e46a0
http://link.springer.com/article/10.1186/s12885-019-5454-2
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7
α-Arrestin ARRDC3 tumor suppressor function is linked to GPCR-induced TAZ activation and breast cancer metastasis
Autor: Logan Chinn, Wen-An Pan, Helen Wedegaertner, Ivette Roca-Mercado, Taranjit S. Gujral, JoAnn Trejo, Aleena K. S. Arakaki
Publikováno v: J Cell Sci
Journal of cell science, vol 134, iss 8
The α-arrestin domain containing protein 3 (ARRDC3) is a tumor suppressor in triple-negative breast carcinoma (TNBC), a highly metastatic subtype of breast cancer that lacks targeted therapies. Thus, understanding the mechanisms and targets of ARRDC
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40bd8c29d3e44bd907e91f86be3bbdc4
https://europepmc.org/articles/PMC8084569/
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8
Abstract A16: The α-arrestin ARRDC3 functions as a metastasis suppressor by regulating GPCR activation of the Hippo pathway
Autor: Helen Wedegaertner, Aleena K. S. Arakaki, Wen-An Pan, JoAnn Trejo
Publikováno v: Molecular Cancer Research. 18:A16-A16
G protein-coupled receptors (GPCRs) are key regulators of the Hippo pathway, a well-established mediator of tumorigenesis and cancer progression. The Hippo pathway is a promising therapeutic target, yet developing inhibitors for the core pathway comp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a5d9dab12483a5b888fc73bafc162fb
https://doi.org/10.1158/1557-3125.hippo19-a16
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