Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Helen Walden"'
Autor:
Francisco Bustos, Anna Segarra-Fas, Viduth K. Chaugule, Lennart Brandenburg, Emma Branigan, Rachel Toth, Thomas Macartney, Axel Knebel, Ronald T. Hay, Helen Walden, Greg M. Findlay
Publikováno v:
Cell Reports, Vol 23, Iss 6, Pp 1599-1611 (2018)
Summary: X-linked intellectual disability (XLID) is a heterogeneous syndrome affecting mainly males. Human genetics has identified >100 XLID genes, although the molecular and developmental mechanisms underpinning this disorder remain unclear. Here, w
Externí odkaz:
https://doaj.org/article/a7ffd6fa9df048268b625e400ceb92e8
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34748 (2012)
Parkin is an E3 ubiquitin ligase, mutations in which cause Autosomal Recessive Parkinson's Disease. Many studies aimed at understanding Parkin function, regulation and dysfunction are performed using N-terminal epitope tags. We report here that the u
Externí odkaz:
https://doaj.org/article/d0daaec419f54ab891600efb7b7a9df2
Autor:
Charlotte Hodson, Helen Walden
Publikováno v:
Anemia, Vol 2012 (2012)
Fanconi Anemia (FA) is a genetic disorder characterized by the inability of patient cells to repair DNA damage caused by interstrand crosslinking agents. There are currently 14 verified FA genes, where mutation of any single gene prevents repair of D
Externí odkaz:
https://doaj.org/article/3b6c2559e6ff49c0aa2b836113f27d3d
Autor:
Chandana Kondapalli, Agne Kazlauskaite, Ning Zhang, Helen I. Woodroof, David G. Campbell, Robert Gourlay, Lynn Burchell, Helen Walden, Thomas J. Macartney, Maria Deak, Axel Knebel, Dario R. Alessi, Miratul M. K. Muqit
Publikováno v:
Open Biology, Vol 2, Iss 5 (2012)
Summary Missense mutations in PTEN-induced kinase 1 (PINK1) cause autosomal-recessive inherited Parkinson's disease (PD). We have exploited our recent discovery that recombinant insect PINK1 is catalytically active to test whether PINK1 directly phos
Externí odkaz:
https://doaj.org/article/a7ccab88220e49e2ad360b217db36be0
Autor:
Kimon Lemonidis, Martin L Rennie, Connor Arkinson, Viduth K Chaugule, Mairi Clarke, James Streetley, Helen Walden
Publikováno v:
The EMBO journalReferences.
Di-monoubiquitination of the FANCI-FANCD2 (ID2) complex is a central and crucial step for the repair of DNA interstrand crosslinks via the Fanconi anaemia pathway. While FANCD2 ubiquitination precedes FANCI ubiquitination, FANCD2 is also deubiquitina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8fbe554624ddf4b4284dae74c0deab7
https://pubmed.ncbi.nlm.nih.gov/36385258
https://pubmed.ncbi.nlm.nih.gov/36385258
Publikováno v:
The FEBS Journal
Fanconi anemia (FA) is a rare genetic disorder caused by mutations in any of the currently 22 known FA genes. The products of these genes, along with other FA-associated proteins, participate in a biochemical pathway, known as the FA pathway. This pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b6b96f5c67b9328414ec8ddf7835af3
https://eprints.gla.ac.uk/244287/1/244287.pdf
https://eprints.gla.ac.uk/244287/1/244287.pdf
Autor:
Kimon Lemonidis, Martin L. Rennie, Connor Arkinson, Viduth K. Chaugule, Mairi Clarke, James Streetley, Helen Walden
The Fanconi Anaemia pathway operates for the repair of interstrand crosslinks and the maintenance of genomic stability upon replication stalling. Di-monoubiquitination of the FANCI-FANCD2 (ID2) complex is a central and crucial step in this pathway. E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adc5a0cfec14cce559513ad83a144b9f
https://doi.org/10.1101/2022.04.07.487446
https://doi.org/10.1101/2022.04.07.487446
Autor:
Karen M. Dunkerley, Anne C. Rintala-Dempsey, Giulia Salzano, Roya Tadayon, Dania Hadi, Kathryn R. Barber, Helen Walden, Gary S. Shaw
The RBR E3 ligase parkin is recruited to the outer mitochondrial membrane (OMM) during oxidative stress where it becomes activated and ubiquitinates numerous proteins. Parkin activation involves binding of a phosphorylated ubiquitin (pUb), followed b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64719b0fc58557ca38527d14da151290
https://eprints.gla.ac.uk/267568/1/267568.pdf
https://eprints.gla.ac.uk/267568/1/267568.pdf
Autor:
Helen Walden, Ruaidhrí J. Carmody, Domenico Somma, Matti Lepistö, Karen Keeshan, Christian Tyrchan, Patrick A. Kiely, Jennifer P. Mitchell, Izaskun Mitxitorena, Emma L. Smith
Publikováno v:
The Journal of Biological Chemistry
The transcription factor NF-ĸB is a master regulator of the innate immune response and plays a central role in inflammatory diseases by mediating the expression of pro-inflammatory cytokines. Ubiquitination-triggered proteasomal degradation of DNA-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d15e4c3eb19191a74e7551445941873
https://doi.org/10.1074/jbc.ra120.014113
https://doi.org/10.1074/jbc.ra120.014113