Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Helen W.L. Lai"'
Publikováno v:
Molecular Brain Research. 123:112-120
Age-related changes and regional differences in caspase expression were determined in the primate brain. Using immunoblot analysis, the levels of endogenous caspase-3, caspase-9 and cytochrome c-triggered activated caspase-3 were examined in brain ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55d689a77114432b15883aa960b2450
https://doi.org/10.1016/j.molbrainres.2004.02.003
https://doi.org/10.1016/j.molbrainres.2004.02.003
Publikováno v:
Neuroembryology and Aging. 3:47-59
Apoptosis is now recognized as an important process in different biological systems, including embryonic development, cell turnover, and immune response against tumorigenic or virus-infected cells. Under either physiological or pathological condition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d3b7235ab6eefac30e595f69308482d
https://doi.org/10.1159/000085404
https://doi.org/10.1159/000085404
Autor:
Helen W.L. Lai, David T. Yew, Wood Yee Chan, Dietrich E. Lorke, Paul W.F. Poon, Lai Yung Wong, Aiqun Zhang
Publikováno v:
Cellular and Molecular Neurobiology. 23:143-164
Senescence-acceleration-prone mice (SAMP8) provide a model to study the influence of early postnatal sound exposure upon the aging auditory midbrain. SAMP8 were exposed to a 9-kHz monotone of either 53- or 65-dB sound pressure level during the first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f8aa68b5c2a58bae5d5df45b7c80be8
https://doi.org/10.1023/a:1022993704617
https://doi.org/10.1023/a:1022993704617
Autor:
Dietrich E. Lorke, Wood Yee Chan, Helen W.L. Lai, Sen Mun Wai, Lai Sin Kung, David T. Yew, Yan Wu
Publikováno v:
Neuroembryology and Aging. 2:1-8
This review highlights similarities in human, rodent and avian eye development, focusing on morphogenesis, proliferative activity, apoptosis and mechanistic aspects during the development of the retina, the iris and the cornea. Retinal morphogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d20b43afb19659f023eeafbe49592f9b
https://doi.org/10.1159/000068496
https://doi.org/10.1159/000068496
Publikováno v:
Experimental Eye Research. 73:897-900
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d348312eb4905a74c1573a376ab584d9
https://doi.org/10.1006/exer.2001.1092
https://doi.org/10.1006/exer.2001.1092
Publikováno v:
Journal of Molecular Neuroscience. 8:75-82
This study investigated terminal dUTP nick-end labeling (TUNEL)-positive cells in the frontal, occipital, and hippocampal cortices of seven normal aging and four Alzheimer’s patients. Significant increase in TUNEL-positive cells was observed in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384bdf1708acc6f5edcbbe92589608fc
https://doi.org/10.1007/bf02736774
https://doi.org/10.1007/bf02736774
Publikováno v:
Neurosignals. 5:343-348
The present work seeks to verify if there is a difference in the number of somatostatin neurons in the cortex between normal aging versus Alzheimer patients and secondly if any of these neurons are dying via apoptosis. In our specimens, immuno-histoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f8d84bcd85042a8fb9310a19573e62
https://doi.org/10.1159/000109207
https://doi.org/10.1159/000109207
Autor:
Valeria Della Maggiore, Joseph T.Y. Wong, Jau-Shyong Hong, Daniel P. Cardinali, Suet Ying Cheng, David M. Bronstein, David T. Yew, Keith R. Pennypacker, Ana I. Esquifino, Patrick Y.D. Wong, Agustín Arce, Wei Ping Li, Hannah Lee, Helen W.L. Lai, Patricia O. Castrillón, Hsiao Chang Chan
Publikováno v:
Neurosignals. 5:I-IV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::755de30b96a7d0b537c0e1793dd743fc
https://doi.org/10.1159/000109210
https://doi.org/10.1159/000109210
Publikováno v:
Neurobiology of aging. 27(5)
Expression of Caspase and Bcl-2 proteins was examined in the hippocampus of senescence-accelerated mice (SAM, P8 and R1 strain) from E19 to 16 months of age. Immunoblotting analysis showed no upregulation of pro-apoptotic proteins (caspase-2L, -3, -6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b228e91a2cec9fadb06a415a4b2c9a
https://pubmed.ncbi.nlm.nih.gov/16198025
https://pubmed.ncbi.nlm.nih.gov/16198025
Autor:
Man-P. Ngan, Helen W.L. Lai, Angie H.Y. Lau, David T. Yew, Kelvin K.W. Kan, John A. Rudd, Man-K. Wai
Publikováno v:
European journal of pharmacology. 506(3)
The action of ondansetron (1 mg/kg, i.p.) and (+)-(2S,3S)-3-(2-methoxybenzylamino)-2-phenylpiperidine (CP-99,994; 10 mg/kg, i.p.) on spontaneous behavior and the emesis induced by cisplatin (10 mg/kg, i.p.) was studied in the ferret. Ondansetron was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398b8f7a3c5b1bbf5d97e5ba86fdd7ff
https://pubmed.ncbi.nlm.nih.gov/15627434
https://pubmed.ncbi.nlm.nih.gov/15627434