Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Helen Tracey"'
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Akademický článek
Recommendations for the Design of Clinical Drug–Drug Interaction Studies With Itraconazole Using a Mechanistic Physiologically‐Based Pharmacokinetic Model
Autor: Yuan Chen, Tamara D. Cabalu, Ernesto Callegari, Heidi Einolf, Lichuan Liu, Neil Parrott, Sheila Annie Peters, Edgar Schuck, Pradeep Sharma, Helen Tracey, Vijay V. Upreti, Ming Zheng, Andy Z.X. Zhu, Stephen D. Hall
Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 9, Pp 685-695 (2019)
Regulatory agencies currently recommend itraconazole (ITZ) as a strong cytochrome P450 3A (CYP3A) inhibitor for clinical drug–drug interaction (DDI) studies. This work by an International Consortium for Innovation and Quality in Pharmaceutical Deve
Externí odkaz: https://doaj.org/article/a909582f81534613a6810cda695e685b
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2
Drug Interactions for Low-Dose Inhaled Nemiralisib: A Case Study Integrating Modeling, In Vitro, and Clinical Investigations
Autor: Alex Georgiou, Andrew W Harrell, Robert Wilson, Kunal S Taskar, Kylie Riddell, Maxine A. Taylor, Miriam Marotti, Helen Tracey, Aarti Patel, Anthony Cahn, Edith M. Hessel
Publikováno v: Drug Metabolism and Disposition. 48:307-316
In vitro data for low-dose inhaled phosphoinositide 3-kinase delta inhibitor nemiralisib revealed that it was a substrate and a potent metabolism-dependent inhibitor of cytochrome P450 (P450) 3A4 and a P-glycoprotein (P-gp) substrate. An integrated i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef465400de76c870a0ae7b28918e63c7
https://doi.org/10.1124/dmd.119.089003
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3
Recommendations for the Design of Clinical Drug–Drug Interaction Studies With Itraconazole Using a Mechanistic Physiologically‐Based Pharmacokinetic Model
Autor: Lichuan Liu, Tamara D. Cabalu, Stephen D. Hall, Ernesto Callegari, Sheila Annie Peters, Andy Z. X. Zhu, Heidi J. Einolf, Yuan Chen, Pradeep Sharma, Helen Tracey, Vijay V. Upreti, Edgar Schuck, Neil Parrott, Ming Zheng
Publikováno v: CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 9, Pp 685-695 (2019)
Regulatory agencies currently recommend itraconazole (ITZ) as a strong cytochrome P450 3A (CYP3A) inhibitor for clinical drug–drug interaction (DDI) studies. This work by an International Consortium for Innovation and Quality in Pharmaceutical Deve
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251f1bfed9a6ce09112a4b49455a0b33
http://europepmc.org/articles/PMC6765698
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5
Uptake and transport of B12-conjugated nanoparticles in airway epithelium☆
Autor: Robyn Fowler, Helen Tracey Horsley, Franco H. Falcone, Cameron Alexander, Driton Vllasaliu, Martin C. Garnett, Snow Stolnik, Bryan Smith
Publikováno v: Journal of Controlled Release
Non-invasive delivery of biotherapeutics, as an attractive alternative to injections, could potentially be achieved through the mucosal surfaces, utilizing nanoscale therapeutic carriers. However, nanoparticles do not readily cross the mucosal barrie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776e2aae4130b0745c25b4171aabc9e6
http://europepmc.org/articles/PMC3898795
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6
In Vitro Investigations into the Roles of Drug Transporters and Metabolizing Enzymes in the Disposition and Drug Interactions of Dolutegravir, a HIV Integrase Inhibitor
Autor: Paul M. Savina, Joseph W. Polli, Eri Kanaoka, Grant T. Generaux, James D. Clarke, Kelly A. Harmon, Helen Tracey, Melinda J. Reese, Joan E. Humphreys, Lindsey O. Webster
Publikováno v: Drug Metabolism and Disposition. 41:353-361
Dolutegravir (DTG; S/GSK1349572) is a potent HIV-1 integrase inhibitor with a distinct resistance profile and a once-daily dose regimen that does not require pharmacokinetic boosting. This work investigated the in vitro drug transport and metabolism
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993f8bf7610b57cb92f53b9a937dadea
https://doi.org/10.1124/dmd.112.048918
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8
Nanoparticle transport in epithelial cells: pathway switching through bioconjugation
Autor: Helen Tracey Horsley, Ian Whitcombe, Driton Vllasaliu, Snow Stolnik, Martin C. Garnett, Francisco Fernández Trillo, Bryan Ronain Smith, Robyn Fowler, Mike Eaton, Cameron Alexander
Publikováno v: Small (Weinheim an der Bergstrasse, Germany). 9(19)
The understanding and control of nanoparticle transport into and through cellular compartments is central to biomedical applications of nanotechnology. Here, it is shown that the transport pathway of 50 nm polystyrene nanoparticles decorated with vit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a18d465029dd94e4a3477b9e8093e1
https://pubmed.ncbi.nlm.nih.gov/23637086
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10
ChemInform Abstract: Total Synthesis of (-)-Histrionicotoxin 285A and (-)-Perhydrohistrionicotoxin
Autor: Andrew B. Holmes, Helen Tracey Horsley, Simon Saubern, James M. MacDonald, John H. Ryan
Publikováno v: ChemInform. 40
Starting from commercially available (S)-glycidol, and via a common intermediate, the total synthesis of (−)-histrionicotoxin 285A and (−)-perhydrohistrionicotoxin has been achieved. Key to this synthesis was the efficient construction of a six-m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::164310d2d9e4cf8b9441c23bd8a59630
https://doi.org/10.1002/chin.200907203
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