Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Helen Susanne Price"'
Autor:
Tarik Khaznadar, Helen Susanne Price, Andy Billinton, Martin E. Swarbrick, David Andrew Stevens, Gerard Martin Paul Giblin, Melanie A. Kay, Anton D. Michel, Nicholas Maughan Clayton, David J. Spalding, Alan Naylor, Alex W. Wilson, Amanda C. Allan, Mark Patrick Healy, Iain P. Chessell, Kristin Bailey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:1892-1896
A novel series of EP4 agonists and antagonists have been identified, and then used to validate their potential in the treatment of inflammatory pain. This paper describes these novel ligands and their activity within a number of pre-clinical models o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c84be478cf9c9b8df7418e7ae7be9570
https://doi.org/10.1016/j.bmcl.2018.03.091
https://doi.org/10.1016/j.bmcl.2018.03.091
Autor:
Xiaobo Su, Wei Zhao, Adrian Hall, Julie Hawkins, Ziqiang Cheng, Yasuji Matsuoka, Yun Jin, Haihua Yu, Guang Yang, Zhaolong Tong, Xiaomin Zhang, Lit-Fui Lau, John D. Elliott, Zehong Wan, Beverley Smith, Yanjiao Zhou, William L. Mitchell, Yingxia Sang, Matthew R. Johnson, Tina Li, David C. Harrison, Eric Yang, Helen Susanne Price, Jian Wang, Jia-Ning Xiang, Ishrut Hussain
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(16)
SAR of a novel series of pyridine-derived γ-secretase modulators is described. Compound 5 was found to be a potent modulator in vitro, which on further profiling, was found to decrease Aβ42 and Aβ40, and maintain (or increase) the levels of total
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d0aa09f7b37afa5db13abc490189d2
https://pubmed.ncbi.nlm.nih.gov/21742495
https://pubmed.ncbi.nlm.nih.gov/21742495
Autor:
Fiona S. Lucas, Helen Susanne Price, John Andrew Corfield, Graham Webb, Steve B. Guntrip, Sean J. Hindley, Alan Naylor, Robert Gleave, Neil Mathews, C. Bountra, Hazel Player, Paul F. Lambeth, Richard M. Hall, Ian B. Campbell, Terry Brown, Andrew P. Blackaby, Joanne O. Wiseman, Kerry Browning, Paul John Beswick, Phillip J. Sidebottom, Nicholas L. Taylor
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
Many years of work have been invested in the identification of potent and selective COX-2 inhibitors for the treatment of chronic inflammatory pain. One issue faced by workers is the balance between the lipophilicity required for potent enzyme inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd1e9f86b785b7810d1398cc8a17706
https://pubmed.ncbi.nlm.nih.gov/19523822
https://pubmed.ncbi.nlm.nih.gov/19523822
Autor:
Paul F. Lambeth, Fiona S. Lucas, Richard Howard Green, Martin E. Swarbrick, Jeremy John Payne, Lee William Page, Malcolm Clive Carter, Paul John Beswick, Alexander J. Stevens, Sharon C Stratton, Neil Anthony Pegg, John Skidmore, Savvas Kleanthous, Alastair J. Stuart, Sue D. Collins, Sharon Bingham, John Andrew Corfield, Richard Stocker, Joanne O. Wiseman, C. David Hartley, Helen Susanne Price, Neil Mathews, Laura J. Chambers, Iain P. Chessell, Robert Gleave, Nick M. Clayton, Alan Naylor, C. Bountra
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
A novel series of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidine-based cyclooxygenase-2 (COX-2) inhibitors, which have a different arrangement of substituents compared to the more common 1,2-diarylheterocycle based molecules, have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dadff8d23a6fefccadd5166b5ed7fd16
https://pubmed.ncbi.nlm.nih.gov/19520573
https://pubmed.ncbi.nlm.nih.gov/19520573
Autor:
Richard L. Jarvest, Richard Stocker, John Andrew Corfield, S. Fernandes, Martin John Slater, C.D. Hartley, Onkar M. P. Singh, C. Wilkinson, V.L.H. Lovegrove, K.J. Medhurst, Malcolm Ellis, George Burton, Pia Thommes, Deborah Lynette Jackson, David Haigh, Nigel R. Parry, E.M. Amphlett, G. Bravi, Alan J. Wonacott, R. Guidetti, Helen Susanne Price, Anne Cheasty, R. Fenwick, P. Shah, David M. Andrews, Peter David Howes
Publikováno v:
Journal of medicinal chemistry. 50(5)
Optimization of a pyrrolidine-based template using structure-based design and physicochemical considerations has provided a development candidate 20b (3082) with submicromolar potency in the HCV replicon and good pharmacokinetic properties.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1d53be85a2e2d11edeea984592657a4
https://pubmed.ncbi.nlm.nih.gov/17269759
https://pubmed.ncbi.nlm.nih.gov/17269759
Autor:
Hazel Player, John Andrew Corfield, Iain P. Chessell, Helen Susanne Price, Sharon C Stratton, Stephen Barry Guntrip, Neil Anthony Pegg, Elizabeth Pickup, Sue D. Collins, Terry Brown, Paul F. Lambeth, Kerry Browning, Sharon Bingham, Paul John Beswick, Alan Naylor, C. Bountra, Claudine Haslam, Ian B. Campbell, Nick M. Clayton, Alexander J. Stevens, Graham Murkit, Fiona S. Lucas, Joanne O. Wiseman, Neil Mathews
Publikováno v:
Bioorganic and medicinal chemistry letters. 14(21)
GW406381 (8), currently undergoing clinical evaluation for the treatment of inflammatory pain is a member of a novel series of 2,3-diaryl-pyrazolo[1,5-b]pyridazine based cyclooxygenase-2 (COX-2) inhibitors, which have been shown to be highly potent a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a5ae5555aa18e5a52bb7cab6ccbcda
http://ora.ox.ac.uk/objects/uuid:3e532779-2daa-4502-8039-5bf9c48950ea
http://ora.ox.ac.uk/objects/uuid:3e532779-2daa-4502-8039-5bf9c48950ea