Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Helen Skaletsky"'
Autor:
Adrianna K. San Roman, Helen Skaletsky, Alexander K. Godfrey, Neha V. Bokil, Levi Teitz, Isani Singh, Laura V. Blanton, Daniel W. Bellott, Tatyana Pyntikova, Julian Lange, Natalia Koutseva, Jennifer F. Hughes, Laura Brown, Sidaly Phou, Ashley Buscetta, Paul Kruszka, Nicole Banks, Amalia Dutra, Evgenia Pak, Patricia C. Lasutschinkow, Colleen Keen, Shanlee M. Davis, Angela E. Lin, Nicole R. Tartaglia, Carole Samango-Sprouse, Maximilian Muenke, David C. Page
Publikováno v:
Cell Genomics, Vol 4, Iss 1, Pp 100462- (2024)
Summary: Somatic cells of human males and females have 45 chromosomes in common, including the “active” X chromosome. In males the 46th chromosome is a Y; in females it is an “inactive” X (Xi). Through linear modeling of autosomal gene expres
Externí odkaz:
https://doaj.org/article/f7bcee4c14104a018d0e1ee125035ddd
Autor:
Jennifer F. Hughes, Helen Skaletsky, Peter K. Nicholls, Alexis Drake, Tatyana Pyntikova, Ting-Jan Cho, Daniel W. Bellott, David C. Page
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background The mammalian X and Y chromosomes originated from a pair of ordinary autosomes. Over the past ~180 million years, the X and Y have become highly differentiated and now only recombine with each other within a short pseudoautosomal
Externí odkaz:
https://doaj.org/article/36f0d6bd4f974647b276c82792290331
Autor:
Adrianna K. San Roman, Alexander K. Godfrey, Helen Skaletsky, Daniel W. Bellott, Abigail F. Groff, Hannah L. Harris, Laura V. Blanton, Jennifer F. Hughes, Laura Brown, Sidaly Phou, Ashley Buscetta, Paul Kruszka, Nicole Banks, Amalia Dutra, Evgenia Pak, Patricia C. Lasutschinkow, Colleen Keen, Shanlee M. Davis, Nicole R. Tartaglia, Carole Samango-Sprouse, Maximilian Muenke, David C. Page
Publikováno v:
Cell Genomics, Vol 3, Iss 2, Pp 100259- (2023)
Summary: The “inactive” X chromosome (Xi) has been assumed to have little impact, in trans, on the “active” X (Xa). To test this, we quantified Xi and Xa gene expression in individuals with one Xa and zero to three Xis. Our linear modeling re
Externí odkaz:
https://doaj.org/article/a25725f53e0c4b88aad1b61692c510c9
Autor:
Daniel W Bellott, Ting-Jan Cho, Emily K Jackson, Helen Skaletsky, Jennifer F Hughes, David C Page
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0269692 (2022)
The reference sequence of structurally complex regions can only be obtained through a highly accurate clone-based approach that we call Single-Haplotype Iterative Mapping and Sequencing (SHIMS). In recent years, improvements to SHIMS have reduced the
Externí odkaz:
https://doaj.org/article/500048f345664927964d120462def086
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 11 (2021)
AbstractGene conversion is GC-biased across a wide range of taxa. Large palindromes on mammalian sex chromosomes undergo frequent gene conversion that maintains arm-to-arm sequence identity greater than 99%, which may increase their susceptibility to
Externí odkaz:
https://doaj.org/article/5ec1cc3aad1746b5907296ee21e8baa5
Autor:
Fang Yang, Sherman Silber, N Adrian Leu, Robert D Oates, Janet D Marszalek, Helen Skaletsky, Laura G Brown, Steve Rozen, David C Page, P Jeremy Wang
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 9, Pp 1198-1210 (2015)
Abstract Genome‐wide recombination is essential for genome stability, evolution, and speciation. Mouse Tex11, an X‐linked meiosis‐specific gene, promotes meiotic recombination and chromosomal synapsis. Here, we report that TEX11 is mutated in i
Externí odkaz:
https://doaj.org/article/06ab8592b1a94f92a6774617d9183d39
Autor:
Michelle A Carmell, Gregoriy A Dokshin, Helen Skaletsky, Yueh-Chiang Hu, Josien C van Wolfswinkel, Kyomi J Igarashi, Daniel W Bellott, Michael Nefedov, Peter W Reddien, George C Enders, Vladimir N Uversky, Craig C Mello, David C Page
Publikováno v:
eLife, Vol 5 (2016)
The advent of sexual reproduction and the evolution of a dedicated germline in multicellular organisms are critical landmarks in eukaryotic evolution. We report an ancient family of GCNA (germ cell nuclear antigen) proteins that arose in the earliest
Externí odkaz:
https://doaj.org/article/bb2777a7496b45ab8f0371093ab6a3f1
Autor:
Li Ling, Fangfang Li, Pinglan Yang, Robert D Oates, Sherman Silber, Cornelia Kurischko, Francis C Luca, N Adrian Leu, Jinwen Zhang, Qiuling Yue, Helen Skaletsky, Laura G Brown, Steve G Rozen, David C Page, P Jeremy Wang, Ke Zheng
Publikováno v:
Biol Reprod
Although hundreds of knockout mice show infertility as a major phenotype, the causative genic mutations of male infertility in humans remain rather limited. Here, we report the identification of a missense mutation (D136G) in the X-linked TAF7L gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04a0f0fbcbcc9d237e3ee33661a7f79
https://doi.org/10.1093/biolre/ioac093
https://doi.org/10.1093/biolre/ioac093
Autor:
Arthur P. Arnold, Xuqi Chen, Michael N. Grzybowski, Janelle M. Ryan, Dale R. Sengelaub, Tara Mohanroy, V. Andree Furlan, William Grisham, Lynn Malloy, Akiko Takizawa, Carrie B. Wiese, Laurent Vergnes, Helen Skaletsky, David C. Page, Karen Reue, Vincent R. Harley, Melinda R. Dwinell, Aron M. Geurts
Publikováno v:
bioRxiv
BackgroundWe have generated a rat model similar to the Four Core Genotypes mouse model, allowing comparison of XX and XY rats with the same type of gonad. The model detects novel sex chromosome effects (XX vs. XY) that contribute to sex differences i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559a36c2812afc8ea3d0f8c3e1815313
https://europepmc.org/articles/PMC9934672/
https://europepmc.org/articles/PMC9934672/
Autor:
Ting-Jan Cho, Jennifer F. Hughes, Donna M. Muzny, James E. Womack, Kim C. Worley, Laura G. Brown, Lucinda Fulton, Catrina Fronick, Daniel W. Bellott, Bhanu P. Chowdhary, Elaine Owens, David C. Page, Shannon Dugan-Rocha, Tina A. Graves-Lindsay, Natalia Koutseva, Terje Raudsepp, Colin Kremitzki, Tatyana Pyntikova, Ziad Khan, William J. Murphy, Helen Skaletsky, Richard A. Gibbs, Wesley C. Warren, Richard K. Wilson
Publikováno v:
Genome Research. 30:1716-1726
Studies of Y Chromosome evolution have focused primarily on gene decay, a consequence of suppression of crossing-over with the X Chromosome. Here, we provide evidence that suppression of X–Y crossing-over unleashed a second dynamic: selfish X–Y a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b6b7baf035063fb9a1606b28c937627
https://doi.org/10.1101/gr.269902.120
https://doi.org/10.1101/gr.269902.120