Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Helen Segal"'
Autor:
Helen Segal, Sruthi Mantri, M. Kyle Cromer, Neehar Bhatia, Maria Grazia Roncarolo, Annalisa Lattanzi, Ciaran M. Lee, David DiGiusto, Rasmus O. Bak, Carsten T. Charlesworth, Josefin Kenrick, Jason Skowronski, Matthew H. Porteus, J. Fraser Wright, Richard L. Frock, Daniel P. Dever, Narae Talbott, Christopher A. Vakulskas, Joab Camarena, Gang Bao, Waracharee Srifa, Premanjali Lahiri, John F. Tisdale
Publikováno v:
Sci Transl Med
Lattanzi, A, Camarena, J, Lahiri, P, Segal, H, Srifa, W, Vakulskas, C A, Frock, R L, Kenrick, J, Lee, C, Talbott, N, Skowronski, J, Cromer, M K, Charlesworth, C T, Bak, R O, Mantri, S, Bao, G, DiGiusto, D, Tisdale, J, Wright, J F, Bhatia, N, Roncarolo, M G, Dever, D P & Porteus, M H 2021, ' Development of β-globin gene correction in human hematopoietic stem cells as a potential durable treatment for sickle cell disease ', Science Translational Medicine, vol. 13, no. 598, eabf2444 . https://doi.org/10.1126/scitranslmed.abf2444
Lattanzi, A, Camarena, J, Lahiri, P, Segal, H, Srifa, W, Vakulskas, C A, Frock, R L, Kenrick, J, Lee, C, Talbott, N, Skowronski, J, Cromer, M K, Charlesworth, C T, Bak, R O, Mantri, S, Bao, G, DiGiusto, D, Tisdale, J, Wright, J F, Bhatia, N, Roncarolo, M G, Dever, D P & Porteus, M H 2021, ' Development of β-globin gene correction in human hematopoietic stem cells as a potential durable treatment for sickle cell disease ', Science Translational Medicine, vol. 13, no. 598, eabf2444 . https://doi.org/10.1126/scitranslmed.abf2444
Sickle cell disease (SCD) is the most common monogenic serious disease with 300,000 births annually worldwide. SCD is autosomal recessive from a single point mutation in codon six of the β-globin gene (HBB) resulting in sickle hemoglobin. Ex vivo β
Autor:
Aurélien Quenault, Benoit Haelewyn, Sara Martinez de Lizarrondo, Emmanuel Touzé, Maxime Gauberti, Peter M. Rothwell, Helen Segal, Denis Vivien, Olivier Etard, Cyrille Orset, Carine Ali
Publikováno v:
Brain-A Journal of Neurology
Brain-A Journal of Neurology, Oxford University Press (OUP), 2016, 140 ((Pt 1)), pp.146-157. ⟨10.1093/brain/aww260⟩
Brain-A Journal of Neurology, 2016, 140 ((Pt 1)), pp.146-157. ⟨10.1093/brain/aww260⟩
Brain-A Journal of Neurology, Oxford University Press (OUP), 2016, 140 ((Pt 1)), pp.146-157. ⟨10.1093/brain/aww260⟩
Brain-A Journal of Neurology, 2016, 140 ((Pt 1)), pp.146-157. ⟨10.1093/brain/aww260⟩
SEE SUN ET AL DOI101093/AWW306 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: About 20% of patients with ischaemic stroke have a preceding transient ischaemic attack, which is clinically defined as focal neurological symptoms of ischaemic origin resolv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdbc1704160d5fc9983cd91a475f7a8d
https://doi.org/10.1093/brain/aww260
https://doi.org/10.1093/brain/aww260
Autor:
Muhammed Saleem Khan, Emilio Ciusani, Alessandro Biffi, Helen Segal, Poneh Adib-Samii, Karen L. Furie, Myriam Fornage, Kaitlin Fitzpatrick, Hugh S. Markus, Peter M. Rothwell, Braxton D. Mitchell, Eugenio Parati, Martin Dichgans, Valerie Valant, S. J. Kittner, Benison C. Lau, Natalia S. Rost, Dale M Gamble, William J. Devan, Alexa Richie, Rainer Malik, Steve Bevan, Cathie Sudlow, Yu-Ching Cheng, Allison Kanakis, Carlos Leiva-Salinas, Silvia Lanfranconi, Joshua C. Bis, Bradford B. Worrall, Pankaj Sharma, Will Longstreth, Joanna M. Wardlaw, Thomas H. Mosley, Kerri L. Wiggins, Andreas Gschwendtner, Christopher Levi, Jonathan Rosand, Guido J. Falcone, Jane Maguire, Bruce M. Psaty, Elizabeth G. Holliday, Matthew Traylor, James F. Meschia, Giorgio B. Boncoraglio
Publikováno v:
Stroke. 44:1609-1615
Background and Purpose— Recently, a novel locus at 17q25 was associated with white matter hyperintensities (WMH) on MRI in stroke-free individuals. We aimed to replicate the association with WMH volume (WMHV) in patients with ischemic stroke. If th
Background and Purpose— Risk of recurrent stroke is high in the first few weeks after transient ischemic attack or stroke and clinical risk prediction tools have only limited accuracy, particularly after the hyperacute phase. Previous studies of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e618614286306448234c093aef040ac7
https://doi.org/10.1161/strokeaha.114.005592
https://doi.org/10.1161/strokeaha.114.005592
Autor:
Paul Harrison, Peter M. Rothwell, Charlene Furtado, Helen Segal, Louise E. Silver, Kevin Blasbery
Background and Purpose— Recent studies suggest that patients who do not respond to aspirin (ASA) therapy may be at increased risk of ischemic vascular events. The availability of simple to use point-of-care (POC) platelet function tests now potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f212a4de05198b337c680ecfd4ea9612
https://doi.org/10.1161/01.str.0000162719.11058.bd
https://doi.org/10.1161/01.str.0000162719.11058.bd
Autor:
Derralynn Hughes, Annette I. Burgess, L Marquardt, RJ Baker, Peter M. Rothwell, Helen Segal, D Poole
Background Fabry disease (FD) is an X-linked lysosomal storage disorder frequently associated with cerebrovascular disease. In recent years, the prevalence of FD has been reported to be up to 4% in cryptogenic young stroke patients. However, there ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fcd6202393ba67fc610ff9009017eba
https://ora.ox.ac.uk/objects/uuid:7fcaf9b2-62de-4ea3-b88d-c14c34962af1
https://ora.ox.ac.uk/objects/uuid:7fcaf9b2-62de-4ea3-b88d-c14c34962af1
Autor:
Diane J. Nugent, Anila Syed, Thomas J. Kunicki, Shirley A. Williams, Peter M. Rothwell, Paul Harrison, Helen Segal
Publikováno v:
Thrombosis and Haemostasis. 101:123-133
SummaryWe studied the effect of prophylactic aspirin (ASA) ingestion on platelet function in 463 patients with stroke, transient ischemic attack (TIA) or acute coronary disease (ACD), using the Platelet Function Analyzer-100 (PFA-100). We correlated
Autor:
Paul Harrison, Helen Segal, Fiona C. Cuthbertson, Anila Syed, Louise E. Silver, Peter M. Rothwell
Publikováno v:
Platelets. 19:119-124
The term aspirin-resistance describes the failure of aspirin to inhibit thromboxane A(2) production. Many new tests have become available for potentially measuring aspirin responses but some are non-specific and do not isolate COX-1 activity. We prev
Publikováno v:
Journal of Thrombosis and Haemostasis. 5:P-S
Autor:
Annette I. Burgess, Helen Segal, Stefan Greisenegger, Peter M. Rothwell, Z Mehta, Debbie L. Poole
Publikováno v:
Stroke. 46(11)
Background and Purpose— Copeptin, the c-terminal portion of provasopressin, is a useful prognostic marker in patients after myocardial infarction and heart failure. More recently, high levels of copeptin have also been associated with worse functio