Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Helen Scarnati"'
Autor:
Ira B. Dicker, Ronald E. Rose, Nicholas A. Meanwell, Tao Wang, Brian McAuliffe, Li Fan, Pin-Fang Lin, Qi Guo, Nannan Zhou, David R. Langley, Hwei-Gene Heidi Wang, Hsu-Tso Ho, Richard J. Colonno, Helen Scarnati, Ralph Abraham, Hua Fang, Jacques Friborg
Publikováno v:
Journal of Virology. 77:10528-10536
BMS-378806 is a recently discovered small-molecule human immunodeficiency virus type 1 (HIV-1) attachment inhibitor with good antiviral activity and pharmacokinetic properties. Here, we demonstrate that the compound targets viral entry by inhibiting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c4565e896fe5411d41d0ddec9e7e96
https://doi.org/10.1128/jvi.77.19.10528-10536.2003
https://doi.org/10.1128/jvi.77.19.10528-10536.2003
Autor:
Robert W. King, Helen Scarnati, Lee Bachelor, Sena Garber, Sylvia Stack, Dean L. Winslow, M. J. Otto
Publikováno v:
Antiviral Research. 28:13-24
The HIV-1 protease (PR) is essential for the production of mature virions. As such, it has become a target for the development of anti-HIV chemotherapeutics. Multiple passages of virus in cell culture in the presence of PR inhibitors have resulted in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db9fb76c3397914e44e919b55d24850
https://doi.org/10.1016/0166-3542(95)00033-i
https://doi.org/10.1016/0166-3542(95)00033-i
Publikováno v:
AIDS Research and Human Retroviruses. 11:107-113
Proviral DNAs from 3 laboratory strains and 21 clinical isolates of HIV-1 were extracted from infected cells after proteinase K digestion and the protease gene was PCR amplified and sequenced directly by the Sanger method. In vitro susceptibilities o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde364c0d1ac6e7ab89070984acc854e
https://doi.org/10.1089/aid.1995.11.107
https://doi.org/10.1089/aid.1995.11.107
Autor:
Helen Scarnati, Dean L. Winslow, Radonna Tritch, R.J. Zagursky, R.A. Horlick, K. Ackerman, Lee T. Bacheler, Elizabeth D. Anton
Publikováno v:
Biochemical and Biophysical Research Communications. 205:1651-1657
A DNA clone of HIV-1 containing the full-length infectious viral sequence was cleaved at a unique Nco I restriction site within the viral genome, and DNA fragments containing the 5' and 3' portions of the HIV genome were subcloned into separate plasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b56417ff255b38429aa00ebd60ac007b
https://doi.org/10.1006/bbrc.1994.2857
https://doi.org/10.1006/bbrc.1994.2857
Autor:
Douglas L. Mayers, Helen Scarnati, James R. Lane, M. J. Otto, Dean L. Winslow, Arlene Bincsik
Publikováno v:
AIDS. 8:753-756
OBJECTIVE: To determine the in vitro susceptibility of primary clinical isolates and laboratory strains of HIV-1 to XM323. METHODS: The AIDS Clinical Trials Group/US Department of Defense p24 antigen-based consensus assay was used to determine in vit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f73f457a09a50264e47eb3d9c076ba4
https://doi.org/10.1097/00002030-199406000-00005
https://doi.org/10.1097/00002030-199406000-00005
Autor:
Patrick Y.S. Lam, M. M. Rayner, C. D. Reid, S. Garber, L. T. Bacheler, Dean L. Winslow, Helen Scarnati, M. J. Otto
Publikováno v:
Antimicrobial Agents and Chemotherapy. 37:2606-2611
XM323 represents a novel class of potent inhibitors of human immunodeficiency virus (HIV) protease. In vitro studies have shown that inhibition of this enzyme translates into potent inhibition of replication of HIV type 1 (HIV-1) and HIV-2. The inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f94d97f62b4d009a78f3b470966034
https://doi.org/10.1128/aac.37.12.2606
https://doi.org/10.1128/aac.37.12.2606
Autor:
Susan Jeffrey, Renay Buckery, Radonna Tritch, Lee T. Bacheler, Helen Scarnati, George J. Hanna, Kelly Logue, Kurt Hertogs, Beverly C. Cordova, David C. Baker, Brendan Larder, Lany Wallace, Karen Gallagher, Chris Rizzo, Richard T. D'Aquila
Publikováno v:
Journal of virology. 75(11)
Efavirenz (also known as DMP 266 or SUSTIVA) is a potent nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) activity and of HIV-1 replication in vitro and in vivo. Most patients on efavirenz-containing r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070b31b4e69cc47f81590d869eaf7ed0
https://pubmed.ncbi.nlm.nih.gov/11333879
https://pubmed.ncbi.nlm.nih.gov/11333879
Autor:
David Baker, Elizabeth D. Anton, Helen Scarnati, M. M. Rayner, Dean L. Winslow, Carol Reid, Sena Garber
Publikováno v:
AIDS (London, England). 10(11)
Objective : To monitor the appearance of HIV-1 variants resistant to inhibition by DMP 266, a benzoxazinone non-nucleoside reverse transcriptase inhibitor using two different protocols for applying drug selective pressure in tissue culture. To compar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3eef96ea6d22e01de0e3278f7b3682f
https://pubmed.ncbi.nlm.nih.gov/8883581
https://pubmed.ncbi.nlm.nih.gov/8883581
Publikováno v:
Antiviral Research. 26:A237
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe8ef0f4175443a852d53ce3501775e9
https://doi.org/10.1016/0166-3542(95)94720-m
https://doi.org/10.1016/0166-3542(95)94720-m