Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Helen S. Kim"'
Publikováno v:
Drug Development Research. 41:10-21
This article discloses the identification of a novel series of the opener of the large-conductance Ca2+-activated K+ (BK) channel, CGS 7181, and its analogs, CGS 7184, CGS 7590, and CGS 7725. The stimulatory effects of these compounds on the channels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51bc039e8c8d5708482817352b1a0ef0
https://doi.org/10.1002/(sici)1098-2299(199705)41:1<10::aid-ddr2>3.0.co
https://doi.org/10.1002/(sici)1098-2299(199705)41:1<10::aid-ddr2>3.0.co
Publikováno v:
European Journal of Pharmacology. 324:277-282
It has been demonstrated previously that endothelin-1 stimulates the Ca2+-activated K+ (BK(Ca)) channel activity in porcine coronary artery smooth muscle cells. The purpose of the present study was to delineate the endothelin receptor subtype involve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc443ed9d011b12c5535d3f1b5c6f617
https://doi.org/10.1016/s0014-2999(97)00079-4
https://doi.org/10.1016/s0014-2999(97)00079-4
Autor:
Shiling Hu, Helen S. Kim
Publikováno v:
European Journal of Pharmacology. 318:461-468
Our recent study revealed that the reported BK(Ca) channel openers NS004 (5-trifluoromethyl-(5-chloro-2-hydroxyphenyl)-1,3-dihydro-2H-benzimidazo le-2-one) and its analog NS1608 (N-(3-(trifluoromethyl)phenyl)-N'-(2-hydroxy-5-chlorophenyl)urea) produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39eadac9989a9cd8b92f0ed5e2d43199
https://doi.org/10.1016/s0014-2999(96)00776-5
https://doi.org/10.1016/s0014-2999(96)00776-5
Differential effects of the BKCa channel openers NS004 and NS1608 in porcine coronary arterial cells
Publikováno v:
European Journal of Pharmacology. 294:357-360
The effects of newly claimed BKCa channel openers NS004 (5-trifluoromethyl-(5-chloro-2-hydroxyphenyl)-1,3-dihydro-2H-benzimidazo le-2- one) and NS1608 (N-(3-(trifluoromethyl)phenyl)-N'-(2-hydroxy-5-chlorophenyl)urea) were investigated on whole-cell K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150d12922f5c2545c2387f61e029473c
https://doi.org/10.1016/0014-2999(95)00744-x
https://doi.org/10.1016/0014-2999(95)00744-x
Autor:
Shiling Hu, Helen S. Kim
Publikováno v:
European Journal of Pharmacology. 230:215-221
Arachidonic acid can be oxidatively metabolized by cytochrome P450 epoxygenase to four regioisomeric epoxyeicosatrienoic acids (5,6-; 8,9-; 11,12-; 14,15-EET), which exhibit vasorelaxant effects in vivo and in vitro with unknown mechanisms. In this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8dfbc00637b89ab9939ac724030a941
https://doi.org/10.1016/0014-2999(93)90805-r
https://doi.org/10.1016/0014-2999(93)90805-r
Publikováno v:
European Journal of Pharmacology. 181:17-21
The D 1 and D 2 subtypes of the dopamine receptor have been distinguished by their opposing effects on levels of neostriatal cyclic adenosine monophosphate (cAMP). The studies reported here show that the content of cyclic guanosine monophosphate (cGM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31647199f032146a7d219ad554b9f96
https://doi.org/10.1016/0014-2999(90)90240-7
https://doi.org/10.1016/0014-2999(90)90240-7
Publikováno v:
Journal of Neurochemistry. 54:1157-1162
Interactions of the potent phencyclidine receptor agonist MK-801 with the dopaminergic system were examined in various brain regions in the rat. MK-801 increased dopamine (DA) metabolism in the pyriform cortex, entorhinal cortex, prefrontal cortex, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::536e939db2fcde84135cec683505e903
https://doi.org/10.1111/j.1471-4159.1990.tb01943.x
https://doi.org/10.1111/j.1471-4159.1990.tb01943.x
Autor:
Shiling Hu, Joseph L. Balwierczak, Dominick DelGrande, Helen S. Kim, Christine M. Krulan, George B. Weiss
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 352(2)
The rank order of potency of a series of benzopyran and cyanoguanidine K+ channel openers (KCOs) for causing relaxation of the PGF2 alpha-precontracted porcine coronary artery was determined. Glyburide, an inhibitor of KATP channels, showed an appare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fef2bf1a0c36ae8fc70350cacbbb0c
https://pubmed.ncbi.nlm.nih.gov/7477446
https://pubmed.ncbi.nlm.nih.gov/7477446
Publikováno v:
European journal of pharmacology. 194(1)
The effects of endothelin-1 (ET-1) on the activity of the large Ca2(+)-activated K+ channel (BK channel) in enzymatically dissociated smooth muscle cells of porcine coronary artery were studied with the cell-attached patch-clamp technique. ET-1 at co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ecbf6ac06419f89b0cd685477571c47
https://pubmed.ncbi.nlm.nih.gov/1647962
https://pubmed.ncbi.nlm.nih.gov/1647962
Publikováno v:
European Journal of Pharmacology. 183:1659
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e973f13fbd1597607143f4adec6c0fc9
https://doi.org/10.1016/0014-2999(90)91951-7
https://doi.org/10.1016/0014-2999(90)91951-7