Drug screening to identify compounds to act as co-therapies for the treatment of Burkholderia species.

Autor: Sam Barker, Sarah V Harding, David Gray, Mark I Richards, Helen S Atkins, Nicholas J Harmer

Publikováno v: PLoS ONE, Vol 16, Iss 3, p e0248119 (2021)

Burkholderia pseudomallei is a soil-dwelling organism present throughout the tropics. It is the causative agent of melioidosis, a disease that is believed to kill 89,000 people per year. It is naturally resistant to many antibiotics, requiring at lea

Externí odkaz: https://doaj.org/article/87a2488d0a28420ab16d82683c70d795

Phenotypic and functional characterization of human memory T cell responses to Burkholderia pseudomallei.

Autor: Patcharaporn Tippayawat, Wipawee Saenwongsa, Jirawan Mahawantung, Duangchan Suwannasaen, Ploenchan Chetchotisakd, Direk Limmathurotsakul, Sharon J Peacock, Philip L Felgner, Helen S Atkins, Richard W Titball, Gregory J Bancroft, Ganjana Lertmemongkolchai

Publikováno v: PLoS Neglected Tropical Diseases, Vol 3, Iss 4, p e407 (2009)

Infection with the Gram-negative bacterium Burkholderia pseudomallei is an important cause of community-acquired lethal sepsis in endemic regions in southeast Asia and northern Australia and is increasingly reported in other tropical areas. In animal

Externí odkaz: https://doaj.org/article/0caa9a71741a44ebaffe6c84eb55cb48

Identification and analysis of novel small molecule inhibitors of RNase E: Implications for antibacterial targeting and regulation of RNase E

Autor: Helen S. Atkins, Louise E. Butt, Paul A. Cox, Bailei C. Spelman, Anastasia J. Callaghan, Charlotte E. Mardle, Darren M. Gowers, Layla R. Goddard, Helen A. Vincent

Publikováno v: Biochemistry and Biophysics Reports
Mardle, C E, Goddard, L, Spelman, B C, Atkins, H S, Butt, L, Cox, P, Gowers, D, Vincent, H & Callaghan, A 2020, ' Identification and analysis of novel small molecule inhibitors of RNase E: implications for antibacterial targeting and regulation of RNase E ', Biochemistry and Biophysics Reports, vol. 23, 100773 . https://doi.org/10.1016/j.bbrep.2020.100773
Biochemistry and Biophysics Reports, Vol 23, Iss, Pp 100773-(2020)

Increasing resistance of bacteria to antibiotics is a serious global challenge and there is a need to unlock the potential of novel antibacterial targets. One such target is the essential prokaryotic endoribonuclease RNase E. Using a combination of i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef51d76ae2970adedba232091804ae73
http://europepmc.org/articles/PMC7284133

Genome-wide assessment of antimicrobial tolerance in Yersinia pseudotuberculosis under ciprofloxacin stress

Autor: Andrew E. Scott, Richard A. Stabler, Sam Willcocks, Kristin K. Huse, Helen S. Atkins, Petra C. F. Oyston, Brendan W. Wren

Publikováno v: Microbial Genomics

Yersinia pseudotuberculosis is a Gram-negative bacterium capable of causing gastrointestinal infection and is closely related to the highly virulent plague bacillus Yersinia pestis . Infections by both species are currently treatable with antibiotics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e62dca947dd5473f9f645985721dc9
http://europepmc.org/articles/PMC6927301

A structural and biochemical comparison of Ribonuclease E homologues from pathogenic bacteria highlights species-specific properties

Autor: Darren M. Gowers, Thomas J. Shakespeare, Anastasia J. Callaghan, Helen S. Atkins, Louise E. Butt, Charlotte E. Mardle, Helen A. Vincent, Layla R. Goddard

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Mardle, C E, Shakespeare, T J, Butt, L E, Goddard, L R, Gowers, D M, Atkins, H S, Vincent, H A & Callaghan, A J 2019, ' A structural and biochemical comparison of Ribonuclease E homologues from pathogenic bacteria highlights species-specific properties ', Scientific Reports, vol. 9, no. 1, 7952 . https://doi.org/10.1038/s41598-019-44385-y

Regulation of gene expression through processing and turnover of RNA is a key mechanism that allows bacteria to rapidly adapt to changing environmental conditions. Consequently, RNA degrading enzymes (ribonucleases; RNases) such as the endoribonuclea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eac6a03357f41298432b637ccef729a2
https://doi.org/10.1038/s41598-019-44385-y