Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Helen Rooks"'
Autor:
John N. Brewin, Helen Rooks, Kate Gardner, Harry Senior, Mrinmayi Morje, Hamel Patel, David Calvet, Pablo Bartolucci, Swee-Lay Thein, Stephan Menzel, David C. Rees
Publikováno v:
Haematologica, Vol 106, Iss 6 (2020)
Externí odkaz:
https://doaj.org/article/c28b2f15c0fa40b79880153968ee1f14
Autor:
Kate Gardner, Tony Fulford, Nicholas Silver, Helen Rooks, Nikolaos Angelis, Marlene Allman, Siana Nkya, Julie Makani, Jo Howard, Rachel Kesse-Adu, David C. Rees, Sara Stuart-Smith, Tullie Yeghen, Moji Awogbade, Raphael Z. Sangeda, Josephine Mgaya, Hamel Patel, Stephen Newhouse, Stephan Menzel, Swee Lay Thein
Publikováno v:
Blood Advances, Vol 2, Iss 3, Pp 235-239 (2018)
Abstract: Fetal hemoglobin (HbF) is a strong modifier of sickle cell disease (SCD) severity and is associated with 3 common genetic loci. Quantifying the genetic effects of the 3 loci would specifically address the benefits of HbF increases in patien
Externí odkaz:
https://doaj.org/article/6f789b316915405c913448948a4037da
Autor:
Helen Rooks, John Brewin, Kate Gardner, Subarna Chakravorty, Stephan Menzel, Anke Hannemann, John Gibson, David C. Rees
Publikováno v:
Haematologica, Vol 104, Iss 3 (2019)
Externí odkaz:
https://doaj.org/article/0ea68c5a2e7949b2a6be8eb916ebb8a1
Autor:
Titilope A Adeyemo, Oyesola O Ojewunmi, Idat A Oyetunji, Helen Rooks, David C Rees, Adebola O Akinsulie, Alani S Akanmu, Swee Lay Thein, Stephan Menzel
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0197927 (2018)
Genetic variants at three quantitative trait loci (QTL) for fetal haemoglobin (HbF), BCL11A, HBS1L-MYB and the β-globin gene cluster, have attracted interest as potential targets of therapeutic strategies for HbF reactivation in sickle cell anaemia
Externí odkaz:
https://doaj.org/article/13a687b26d7c418cb662b2e065d78bc7
Autor:
Siana Nkya Mtatiro, Tarjinder Singh, Helen Rooks, Josephine Mgaya, Harvest Mariki, Deogratius Soka, Bruno Mmbando, Evarist Msaki, Iris Kolder, Swee Lay Thein, Stephan Menzel, Sharon E Cox, Julie Makani, Jeffrey C Barrett
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111464 (2014)
Fetal hemoglobin (HbF) is an important modulator of sickle cell disease (SCD). HbF has previously been shown to be affected by variants at three loci on chromosomes 2, 6 and 11, but it is likely that additional loci remain to be discovered.We conduct
Externí odkaz:
https://doaj.org/article/36304838133a4c1aa3a02d07da489ce3
Autor:
Oyesola O. Ojewunmi, Titilope A. Adeyemo, Ajoke I. Oyetunji, Bassey Inyang, Afolashade Akinrindoye, Baraka S. Mkumbe, Kate Gardner, Helen Rooks, John Brewin, Hamel Patel, Sang-Hyuck Lee, Raymond Chung, Sara Rashkin, Guolian Kang, Reuben Chianumba, Raphael Sangeda, Liberata Mwita, Hezekiah Isa, Uche-Nnebe Agumadu, Rosemary Ekong, Jamilu A. Faruk, Bello Y. Jamoh, Niyi M. Adebiyi, Ismail A. Umar, Abdulaziz Hassan, Christopher Grace, Anuj Goel, Baba P.D. Inusa, Mario Falchi, Siana Nkya, Julie Makani, Hafsat R. Ahmad, Obiageli Nnodu, John Strouboulis, Stephan Menzel
BackgroundThe clinical severity of sickle cell disease (SCD) is strongly influenced by the level of fetal haemoglobin (HbF) persistent in each patient. Three major HbF loci (BCL11A,HBS1L-MYB, andXmn1-HBG2) have been reported, but a considerable hidde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eec5aa8af3810e908446c6f3dd1ab4d2
https://doi.org/10.1101/2023.05.16.23289851
https://doi.org/10.1101/2023.05.16.23289851
Autor:
Florence Urio, Siana Nkya, Josephine Mgaya, Helen Rooks, Peter Ponsian, Sara El Hoss, Teddy Mselle, Julie Makani, Stephan Menzel
Publikováno v:
American Journal of Hematology. 98
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd146830f626d3d9d407248ba9f164b6
https://doi.org/10.1002/ajh.26914
https://doi.org/10.1002/ajh.26914
Autor:
Harry Senior, David C. Rees, Mrinmayi Morje, Stephan Menzel, Pablo Bartolucci, Hamel Patel, John N. Brewin, David Calvet, Helen Rooks, Kate Gardner, Swee-Lay Thein
Publikováno v:
Haematologica
Not available.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9221885f03d67937ed03a1749a9e096
https://doi.org/10.3324/haematol.2020.265827
https://doi.org/10.3324/haematol.2020.265827
Autor:
Upendo Masamu, Helen Rooks, Ted Mselle, Florence Urio, Siana Nkya, Stephan Menzel, Julie Makani, Marco Brumat, Bruno Mmbando, Lucio Luzzatto, Raphael Z. Sangeda, Josephine Mgaya
Publikováno v:
British Journal of Haematology. 191:888-896
Patients with sickle cell disease (SCD) with high fetal haemoglobin (HbF) tend to have a lower incidence of complications and longer survival due to inhibition of deoxyhaemoglobin S (HbS) polymerisation by HbF. HbF-containing cells, namely F cells, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e312a9ae0ea1b1bd7823342cf4d4797
https://doi.org/10.1111/bjh.17102
https://doi.org/10.1111/bjh.17102
Autor:
Kate Gardner, Anke Hannemann, Helen Rooks, David C. Rees, John N. Brewin, John S. Gibson, Stephan Menzel, Subarna Chakravorty
Publikováno v:
Haematologica. 104:e91-e93
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c1b1c70f72ec6fd9bd91f6a526232c
https://doi.org/10.3324/haematol.2018.202697
https://doi.org/10.3324/haematol.2018.202697