Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Helen Ray-Jones"'
Autor:
Helen Ray-Jones, Kate Duffus, Amanda McGovern, Paul Martin, Chenfu Shi, Jenny Hankinson, Oliver Gough, Annie Yarwood, Andrew P. Morris, Antony Adamson, Christopher Taylor, James Ding, Vasanthi Priyadarshini Gaddi, Yao Fu, Patrick Gaffney, Gisela Orozco, Richard B. Warren, Steve Eyre
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-20 (2020)
Abstract Background Genome-wide association studies (GWAS) have uncovered many genetic risk loci for psoriasis, yet many remain uncharacterised in terms of the causal gene and their biological mechanism in disease. This is largely a result of the fin
Externí odkaz:
https://doaj.org/article/fc874bf79d974ecf8ffc27cc8532e984
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Genetic variants showing associations with specific biological traits and diseases detected by genome-wide association studies (GWAS) commonly map to non-coding DNA regulatory regions. Many of these regions are located considerable distances away fro
Externí odkaz:
https://doaj.org/article/502ff5588bf84dc98184cb382a6f0b34
Autor:
Valeriya Malysheva, Helen Ray-Jones, Tareian A. Cazares, Owen Clay, David Ohayon, Pavel Artemov, Joseph A. Wayman, Monica Della Rosa, Carmen Petitjean, Clarissa Booth, Joseph I.J. Ellaway, William R. Orchard, Xiaoting Chen, Sreeja Parameswaran, Takashi Nagano, Peter Fraser, Stefan Schoenfelder, Matthew T. Weirauch, Leah C. Kottyan, David F. Smith, Nick Powell, Jill M. Weimer, Chris Wallace, Emily R. Miraldi, Stephen Waggoner, Mikhail Spivakov
Innate lymphoid cells (ILCs) are rare tissue-resident “helper” lymphocytes that do not express diversified antigen receptors. Type 3 ILCs (ILC3s) are an important class of these cells enriched in the respiratory and intestinal mucosa, where they
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df60fce80a2b652c86b738cb5409ad98
https://doi.org/10.1101/2022.10.19.512842
https://doi.org/10.1101/2022.10.19.512842
Autor:
William R. Orchard, Valeriya Malysheva, Jonathan Cairns, Steven Wingett, Paula Freire-Pritchett, Mikhail Spivakov, Helen Ray-Jones, Chris Eijsbouts, Chris Wallace, Monica Della Rosa
Publikováno v:
Nat Protoc
Capture Hi-C is widely used to obtain high-resolution profiles of chromosomal interactions involving, at least on one end, regions of interest such as gene promoters. Signal detection in Capture Hi-C data is challenging and cannot be adequately accom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5b7d6c8db4063913df826129dd424f
Autor:
Helen Ray-Jones, Mikhail Spivakov
Publikováno v:
Developmental cell. 57(12)
In a recent issue of Nature, Zuin et al. (2022) integrate a transcriptional enhancer into various genomic locations surrounding a reporter gene promoter in order to determine how enhancer-promoter proximity affects gene expression. Their findings sug
Autor:
Richard B. Warren, Jenny Hankinson, Patrick M. Gaffney, Magnus Rattray, Oliver Gough, Stephen Eyre, Gisela Orozco, Kate Duffus, Annie Yarwood, Chenfu Shi, Yao Fu, James Ding, Amanda McGovern, Paul Martin, Helen Ray-Jones, Vasanthipriyadarshini Gaddi
Publikováno v:
Shi, C, Ray-Jones, H, Ding, J, Duffus, K, Fu, Y, Gaddi, V P, Gough, O, Hankinson, J, Martin, P, McGovern, A, Yarwood, A, Gaffney, P, Eyre, S, Rattray, M, Warren, R B & Orozco, G 2021, ' Chromatin Looping Links Target Genes with Genetic Risk Loci for Dermatological Traits ', The Journal of Investigative Dermatology, vol. 141, no. 8, pp. 1975-1984 . https://doi.org/10.1016/j.jid.2021.01.015
Chromatin looping between regulatory elements and gene promoters presents a potential mechanism whereby disease risk variants affect their target genes. In this study, we use H3K27ac HiChIP, a method for assaying the active chromatin interactome in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d10994e884e95df7c74f8f969732cb8
https://research.manchester.ac.uk/en/publications/91e6427b-0c9e-4dfa-8686-9d2cb38a339a
https://research.manchester.ac.uk/en/publications/91e6427b-0c9e-4dfa-8686-9d2cb38a339a
Autor:
Jessie D. Trujillo, Emily R. Miraldi, Jan Bakker, Benjamin R. tenOever, Andre L. Moreira, Helen Ray-Jones, Ivan Marazzi, Simin Zheng, Nan Zhao, Laura Campisi, Michael Schotsaert, Zeyu Zhu, Sven Heinz, Elaine Shum, Christopher Benner, Jessica Sook Yuin Ho, Anna Junxia Zhang, Adolfo García-Sastre, Sreeja Parameswaran, Joseph A. Wayman, Matthew T. Weirauch, Anand D. Jeyasekharan, Yesai Fstkchyan, Igor Morozov, Wen-Chun Liu, Minji Byun, Sumit K. Chanda, Sabarish V. Indran, Natasha N. Gaudreault, Mikhail Spivakov, Honglin Chen, Alba Escalera, Bobo Wing-Yee Mok, Kris M. White, Juergen A. Richt, Mariano Carossino, Valeriya Malysheva, Randy A. Albrecht, Tristan X. Jordan, Teresa Aydillo, Robert Sebra, Betsaida Salom Melo, Andrew Chak-Yiu Lee, Sonia Jangra, Udeni B. R. Balasuriya, David A. Meekins, Ernesto Guccione, Siu Ying Lau, Soner Yildiz, Michiel J. Thiecke, David A. Kaufman, Raveen Rathnasinghe, Honglian Liu
Publikováno v:
Cell, 184(10), 2618-2632.e17. Cell Press
Cell, vol 184, iss 10
Cell
Cell, vol 184, iss 10
Cell
The ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently affecting millions of lives worldwide. Large retrospective studies indicate that an elevated level of inflammatory cytokines and pro-inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d169781a64bf58af62230f5b19d8e6ad
https://pure.eur.nl/en/publications/c6a3d84a-3a2d-4ff6-9904-1d7f6b018446
https://pure.eur.nl/en/publications/c6a3d84a-3a2d-4ff6-9904-1d7f6b018446
Autor:
Jessica Sook Yuin Ho, Bobo Wing-Yee Mok, Laura Campisi, Tristan Jordan, Soner Yildiz, Sreeja Parameswaran, Joseph A Wayman, Natasha N Gaudreault, David A Meekins, Sabarish V. Indran, Igor Morozov, Jessie D Trujillo, Yesai S Fstkchyan, Raveen Rathnasinghe, Zeyu Zhu, Simin Zheng, Nan Zhao, Kris White, Helen Ray-Jones, Valeriya Malysheva, Michiel J Thiecke, Siu-Ying Lau, Honglian Liu, Anna Junxia Zhang, Andrew Chak-Yiu Lee, Wen-Chun Liu, Teresa Aydillo, Betsaida Salom Melo, Ernesto Guccione, Robert Sebra, Elaine Shum, Jan Bakker, David A. Kaufman, Andre L. Moreira, Mariano Carossino, Udeni B R Balasuriya, Minji Byun, Emily R Miraldi, Randy A Albrecht, Michael Schotsaert, Adolfo Garcia-Sastre, Sumit K Chanda, Anand D Jeyasekharan, Benjamin R TenOever, Mikhail Spivakov, Matthew T Weirauch, Sven Heinz, Honglin Chen, Christopher Benner, Juergen A Richt, Ivan Marazzi
Publikováno v:
bioRxiv
SUMMARYThe ongoing pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is currently affecting millions of lives worldwide. Large retrospective studies indicate that an elevated level of inflammatory cytokines and pro-infla
Autor:
Jenny Hankinson, Steve Eyre, Patrick M. Gaffney, Gisela Orozco, Oliver Gough, Amanda McGovern, James Ding, Andrew P. Morris, Kate Duffus, Helen Ray-Jones, Paul Martin, Yao Fu, Vasanthi Priyadarshini Gaddi, Chenfu Shi, Antony Adamson, Richard B. Warren, Christopher J. Taylor, Annie Yarwood
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-20 (2020)
BMC Biology
Ray-Jones, H, Duffus, K, Mcgovern, A, Martin, P, Shi, C, Hankinson, J, Gough, O, Yarwood, A, Morris, A, Adamson, A, Taylor, C, Ding, J, Gaddi, V, Fu, Y, Gaffney, P, Orozco, G, Warren, R & Eyre, S 2020, ' Mapping DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31 ', BMC Biology, vol. 18, no. 1, 47 . https://doi.org/10.1186/s12915-020-00779-3
BMC Biology
Ray-Jones, H, Duffus, K, Mcgovern, A, Martin, P, Shi, C, Hankinson, J, Gough, O, Yarwood, A, Morris, A, Adamson, A, Taylor, C, Ding, J, Gaddi, V, Fu, Y, Gaffney, P, Orozco, G, Warren, R & Eyre, S 2020, ' Mapping DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31 ', BMC Biology, vol. 18, no. 1, 47 . https://doi.org/10.1186/s12915-020-00779-3
Background Genome-wide association studies (GWAS) have uncovered many genetic risk loci for psoriasis, yet many remain uncharacterised in terms of the causal gene and their biological mechanism in disease. This is largely a result of the findings tha
Autor:
Gisela Orozco, Richard B. Warren, Jenny Hankinson, Helen Ray-Jones, Chenfu Shi, Magnus Rattray, Patrick M. Gaffney, Amanda McGovern, Yao Fu, Annie Yarwood, Paul Martin, Oliver Gough, Steve Eyre, Vasanthi Priyadarshini Gaddi, Kate Duffus, James Ding
In the last 15 years Genome wide association studies (GWAS) have uncovered the genetic factors that contribute to disease risk for many disorders, yet the biological significance of many of these associations remain unclear. This is because about 90%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::839bc0bab0d6ffe32d71648f412a25c6
https://doi.org/10.1101/2020.03.05.973271
https://doi.org/10.1101/2020.03.05.973271