Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Helen R. Wagstaffe"'
Autor:
Helen R. Wagstaffe, Marina Johnson, Guled Osman, Patricia Martin, Paula Carranza, David Goldblatt
Publikováno v:
mSphere, Vol 8, Iss 2 (2023)
ABSTRACT Klebsiella pneumoniae, a Gram-negative bacterium, has been listed as a critical pathogen for urgent intervention by the World Health Organization. With no licensed vaccine and increasing resistance to antibiotics, Klebsiella pneumoniae cause
Externí odkaz:
https://doaj.org/article/62558cf25202402e917dbce340109050
Autor:
Helen R. Wagstaffe, Giada Susannini, Rodolphe Thiébaut, Laura Richert, Yves Lévy, Viki Bockstal, Jeroen N. Stoop, Kerstin Luhn, Macaya Douoguih, Eleanor M. Riley, Christine Lacabaratz, Martin R. Goodier
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-10 (2021)
Abstract Natural killer (NK) cells are implicated among immune effectors after vaccination against viral pathogens, including Ebola virus. The two-dose heterologous Ebola virus vaccine regimen, adenovirus type 26.ZEBOV followed by modified vaccinia A
Externí odkaz:
https://doaj.org/article/9fcd68f95a2b493f8092a3429bbfd28d
Autor:
Helen R. Wagstaffe, Omu Anzala, Hannah Kibuuka, Zacchaeus Anywaine, Sodiomon B. Sirima, Rodolphe Thiébaut, Laura Richert, Yves Levy, Christine Lacabaratz, Viki Bockstal, Kerstin Luhn, Macaya Douoguih, Martin R. Goodier
Publikováno v:
Vaccines, Vol 10, Iss 6, p 884 (2022)
Natural killer cells play an important role in the control of viral infections both by regulating acquired immune responses and as potent innate or antibody-mediated cytotoxic effector cells. NK cells have been implicated in control of Ebola virus in
Externí odkaz:
https://doaj.org/article/6610edce64264aaa83c15c61d4bb109b
Autor:
Rik G.H. Lindeboom, Kaylee B. Worlock, Lisa M. Dratva, Masahiro Yoshida, David Scobie, Helen R. Wagstaffe, Laura Richardson, Anna Wilbrey-Clark, Josephine L. Barnes, Krzysztof Polanski, Jessica Allen-Hyttinen, Puja Mehta, Dinithi Sumanaweera, Jacqueline Boccacino, Waradon Sungnak, Ni Huang, Lira Mamanova, Rakesh Kapuge, Liam Bolt, Elena Prigmore, Ben Killingley, Mariya Kalinova, Maria Mayer, Alison Boyers, Alex Mann, Vitor Teixeira, Sam M. Janes, Rachel C. Chambers, Muzlifah Haniffa, Andrew Catchpole, Robert Heyderman, Mahdad Noursadeghi, Benny Chain, Andreas Mayer, Kerstin B. Meyer, Christopher Chiu, Marko Z. Nikolić, Sarah A. Teichmann
The COVID-19 pandemic is an ongoing global health threat, yet our understanding of the cellular disease dynamics remains limited. In our unique COVID-19 human challenge study we used single cell genomics of nasopharyngeal swabs and blood to temporall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d220950228bcc70a9b7e6d3734f32b9f
https://doi.org/10.1101/2023.04.13.23288227
https://doi.org/10.1101/2023.04.13.23288227
Autor:
Georgi Shukarev, Helen R Wagstaffe, Jeroen N Stoop, Viki Bockstal, Eleanor M. Riley, Kerstin Luhn, Matthew D. Snape, Andrew J. Pollard, Martin R. Goodier, Macaya Douoguih, Elizabeth A. Clutterbuck
Publikováno v:
The Journal of Infectious Diseases
Wagstaffe, H R, Clutterbuck, E A, Bockstal, V, Stoop, J N, Luhn, K, Douoguih, M, Shukarev, G, Snape, M D, Pollard, A J, Riley, E M & Goodier, M R 2019, ' Antibody-Dependent Natural Killer Cell Activation after Ebola Vaccination ', The Journal of Infectious Diseases . https://doi.org/10.1093/infdis/jiz657
Wagstaffe, H R, Clutterbuck, E A, Bockstal, V, Stoop, J N, Luhn, K, Douoguih, M, Shukarev, G, Snape, M D, Pollard, A J, Riley, E M & Goodier, M R 2019, ' Antibody-Dependent Natural Killer Cell Activation after Ebola Vaccination ', The Journal of Infectious Diseases . https://doi.org/10.1093/infdis/jiz657
Background Antibody Fc-mediated functions, such as antibody-dependent cellular cytotoxicity, contribute to vaccine-induced protection against viral infections. Fc-mediated function of anti-Ebola glycoprotein (GP) antibodies suggest that Fc-dependent
Autor:
Helen R Wagstaffe, Martin R. Goodier, Natalie Prevatt, Eleanor M. Riley, Jason P. Mooney, Martin J. Holland, Ron H Behrens, Asia-Sophia Wolf, Harry Pickering, Joanna Houghton
Publikováno v:
The Journal of Immunology. 203:1609-1618
Cytokine-induced memory-like (CIML) NK cells generated in response to proinflammatory cytokines in vitro and in vivo can also be generated by vaccination, exhibiting heightened responses to cytokine stimulation months after their initial induction. O
Autor:
Jeroen N Stoop, Macaya Douoguih, Georgi Shukarev, Viki Bockstal, Matthew D. Snape, Helen R Wagstaffe, Elizabeth A. Clutterbuck, Eleanor M. Riley, Andrew J. Pollard, Kerstin Luhn, Martin R. Goodier
Publikováno v:
The Journal of Clinical Investigation
Journal of Clinical Investigation
Wagstaffe, H R, Clutterbuck, E A, Bockstal, V, Stoop, J N, Luhn, K, Douoguih, M, Shukarev, G, Snape, M D, Pollard, A J, Riley, E & Goodier, M R 2020, ' Ebola virus glycoprotein stimulates IL-18 dependent natural killer cell responses ', Journal of Clinical Investigation, vol. 130, no. 7, pp. 3936-3946 . https://doi.org/10.1172/JCI132438
Journal of Clinical Investigation
Wagstaffe, H R, Clutterbuck, E A, Bockstal, V, Stoop, J N, Luhn, K, Douoguih, M, Shukarev, G, Snape, M D, Pollard, A J, Riley, E & Goodier, M R 2020, ' Ebola virus glycoprotein stimulates IL-18 dependent natural killer cell responses ', Journal of Clinical Investigation, vol. 130, no. 7, pp. 3936-3946 . https://doi.org/10.1172/JCI132438
BACKGROUND NK cells are activated by innate cytokines and viral ligands to kill virus-infected cells. These functions are enhanced during secondary immune responses and after vaccination by synergy with effector T cells and virus-specific antibodies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81181ba11dd89380301e8cad8cf648fe
Publikováno v:
The Journal of Immunology Author Choice
Wagstaffe, H R, Nielsen, C M, Riley, E M & Goodier, M R 2018, ' IL-15 Promotes Polyfunctional NK Cell Responses to Influenza by Boosting IL-12 Production ', Journal of Immunology, vol. 200, no. 8, pp. 2738-2747 . https://doi.org/10.4049/jimmunol.1701614
Wagstaffe, H R, Nielsen, C M, Riley, E M & Goodier, M R 2018, ' IL-15 Promotes Polyfunctional NK Cell Responses to Influenza by Boosting IL-12 Production ', Journal of Immunology, vol. 200, no. 8, pp. 2738-2747 . https://doi.org/10.4049/jimmunol.1701614
IL-15 is a key regulator of NK cell maintenance and proliferation and synergizes with other myeloid cell–derived cytokines to enhance NK cell effector function. At low concentrations, trans-presentation of IL-15 by dendritic cells can activate NK c
Publikováno v:
Clinical & Translational Immunology
Wagstaffe, H R, Mooney, J P, Riley, E M & Goodier, M R 2018, ' Vaccinating for natural killer cell effector functions ', Clinical & translational immunology, vol. 7, no. 1, pp. e1010 . https://doi.org/10.1002/cti2.1010
Wagstaffe, H R, Mooney, J P, Riley, E M & Goodier, M R 2018, ' Vaccinating for natural killer cell effector functions ', Clinical & translational immunology, vol. 7, no. 1, pp. e1010 . https://doi.org/10.1002/cti2.1010
Vaccination has proved to be highly effective in reducing global mortality and eliminating infectious diseases. Building on this success will depend on the development of new and improved vaccines, new methods to determine efficacy and optimum dosing