Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Helen R. Valentine"'
Autor:
Hisham Mehanna, Tanguy Y. Seiwert, Benjamin E. Willcox, Jean-Baptiste Cazier, Catharine M. L. West, Jonathan Deeks, Andrew D. Beggs, Daniel A. Tennant, Gary Middleton, Kalu U.E. Ogbureke, Steven P. Lee, Arun Khattri, Riyue Bao, Gordon B. Ryan, Baksho Kaul, Margaret Hartley, Jennifer L. Bryant, Nikolaos Batis, Rachel J. Spruce, Helen R. Valentine, Sandra V. von Zeidler, Christopher J. Bagnall, Neeraj Lal, Lucinda Archer, Maha Ibrahim, Albert N. Menezes, Jill M. Brooks
Purpose:Intratumoral hypoxia and immunity have been correlated with patient outcome in various tumor settings. However, these factors are not currently considered for treatment selection in head and neck cancer (HNC) due to lack of validated biomarke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0f7d3ccb0356118104dd9a5b5c5f51
https://doi.org/10.1158/1078-0432.c.6527511.v1
https://doi.org/10.1158/1078-0432.c.6527511.v1
Autor:
Hisham Mehanna, Tanguy Y. Seiwert, Benjamin E. Willcox, Jean-Baptiste Cazier, Catharine M. L. West, Jonathan Deeks, Andrew D. Beggs, Daniel A. Tennant, Gary Middleton, Kalu U.E. Ogbureke, Steven P. Lee, Arun Khattri, Riyue Bao, Gordon B. Ryan, Baksho Kaul, Margaret Hartley, Jennifer L. Bryant, Nikolaos Batis, Rachel J. Spruce, Helen R. Valentine, Sandra V. von Zeidler, Christopher J. Bagnall, Neeraj Lal, Lucinda Archer, Maha Ibrahim, Albert N. Menezes, Jill M. Brooks
Figure S1. Gene order within the cluster defined groups. Figure S2. Analysis of individual hypoxia and immune gene signatures. Figure S3. Flow diagram showing progress of patient samples through study for Correlate cohort Figure S4. Relationship betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cfab9a3f027758f48cf0cc051884977
https://doi.org/10.1158/1078-0432.22470306.v1
https://doi.org/10.1158/1078-0432.22470306.v1
Autor:
Adrian L. Harris, Catharine M.L. West, Pat Price, Philip Sloan, Nick Slevin, Brian Musgrove, Jarrod J. Homer, Rogan J. Corbridge, Graham J. Cox, Ketan A. Shah, Helen Turley, Helen R. Valentine, Crispin Miller, Priyamal Silva, Francesca M. Buffa, Stuart C. Winter
Supplementary Tables 1-4, Flowchart 1 from Relation of a Hypoxia Metagene Derived from Head and Neck Cancer to Prognosis of Multiple Cancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c47a678162604c7dcba39a8b41e8f6
https://doi.org/10.1158/0008-5472.22365974
https://doi.org/10.1158/0008-5472.22365974
Autor:
Adrian L. Harris, Catharine M.L. West, Pat Price, Philip Sloan, Nick Slevin, Brian Musgrove, Jarrod J. Homer, Rogan J. Corbridge, Graham J. Cox, Ketan A. Shah, Helen Turley, Helen R. Valentine, Crispin Miller, Priyamal Silva, Francesca M. Buffa, Stuart C. Winter
Affymetrix U133plus2 GeneChips were used to profile 59 head and neck squamous cell cancers. A hypoxia metagene was obtained by analysis of genes whose in vivo expression clustered with the expression of 10 well-known hypoxia-regulated genes (e.g., CA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952c089cb5e6a026ac49853e99f734c4
https://doi.org/10.1158/0008-5472.c.6494933.v1
https://doi.org/10.1158/0008-5472.c.6494933.v1
Autor:
Mairah T. Khan, Lars Dyrskjøt, Ronnie Rodrigues Pereira, Joely J. Irlam-Jones, Kai Aragaki, Helen R Valentine, Ananya Choudhury, Peter Hoskin, Brian Lane, Catharine M L West, David J. McConkey
Publikováno v:
Khan, M T, Irlam-Jones, J J, Pereira, R R, Lane, B, Valentine, H R, Aragaki, K, Dyrskjøt, L, McConkey, D J, Hoskin, P J, Choudhury, A & West, C M L 2021, ' A miRNA signature predicts benefit from addition of hypoxia-modifying therapy to radiation treatment in invasive bladder cancer ', British Journal of Cancer, vol. 125, no. 1, pp. 85-93 . https://doi.org/10.1038/s41416-021-01326-9
British Journal of Cancer
British Journal of Cancer
Background miRNAs are promising biomarkers in oncology as their small size makes them less susceptible to degradation than mRNA in FFPE tissue. We aimed to derive a hypoxia-associated miRNA signature for bladder cancer. Methods Taqman miRNA array car
Autor:
Neeraj Lal, Riyue Bao, Sandra Ventorin Von Zeidler, Arun Khattri, Helen R Valentine, Albert N. Menezes, Jean-Baptiste Cazier, Hisham Mehanna, Tanguy Y. Seiwert, Maha Ibrahim, Steven P. Lee, Jonathan J Deeks, Lucinda Archer, Daniel A. Tennant, Andrew D Beggs, Christopher Bagnall, Margaret Hartley, Nikolaos Batis, Kalu U.E. Ogbureke, Baksho Kaul, Jill Brooks, Gary Middleton, Jennifer L. Bryant, Catharine M L West, Gordon B. Ryan, Rachel Spruce, Benjamin E. Willcox
Publikováno v:
Clinical Cancer Research. 25:5315-5328
Purpose: Intratumoral hypoxia and immunity have been correlated with patient outcome in various tumor settings. However, these factors are not currently considered for treatment selection in head and neck cancer (HNC) due to lack of validated biomark
Autor:
Catharine M L West, Lingjian Yang, Brian Lane, Joely J Irlam, Helen R Valentine, Yee Pei Song, Hitesh Mistry, Ananya Choudhury, Peter Hoskin
Publikováno v:
Song, Y P, Mistry, H, Irlam, J, Valentine, H, Yang, L, Lane, B, West, C, Choudhury, A & Hoskin, P J 2021, ' Long-Term Outcomes of Radical Radiation Therapy with Hypoxia Modification with Biomarker Discovery for Stratification: 10-Year Update of the BCON (Bladder Carbogen Nicotinamide) Phase 3 Randomized Trial (ISRCTN45938399) ', International Journal of Radiation: Oncology-Biology-Physics . https://doi.org/10.1016/j.ijrobp.2021.03.001
PurposeMany muscle-invasive bladder cancers are hypoxic, which limits the efficacy of radiation therapy. Hypoxia modification using carbogen and nicotinamide has been tested in a phase 3 trial, Bladder Carbogen Nicotinamide. We present mature follow-
Autor:
Tim A. D. Smith, Catharine M L West, Omneya A. AbdelKarem, Ananya Choudhury, Joely J. Irlam-Jones, Brian Lane, B. Bibby, Helen Denley, Helen R Valentine
Publikováno v:
Smith, T, Abdelkarem, O A I, Irlam, J, Lane, B, Valentine, H, Bibby, B, Denley, H, Choudhury, A & West, C 2020, ' Selection of endogenous control genes for normalising gene expression data derived from formalin-fixed paraffin-embedded tumour tissue ', Nature-London-. https://doi.org/10.1038/s41598-020-74380-7
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Quantitative real time polymerase chain reaction (qPCR) data are normalised using endogenous control genes. We aimed to: (1) demonstrate a pathway to identify endogenous control genes for qPCR analysis of formalin-fixed paraffin-embedded (FFPE) tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a9aae6477b7e692030481acccef819
https://research.manchester.ac.uk/en/publications/5f7828b5-7ded-42fd-9f2b-d891bbc422d0
https://research.manchester.ac.uk/en/publications/5f7828b5-7ded-42fd-9f2b-d891bbc422d0
Autor:
Catharine M L West, Joely J. Irlam-Jones, Helen R Valentine, Elisabet More, Mairah T. Khan, Peter Hoskin, Lingjian Yang, Ananya Choudhury
Publikováno v:
Radiation research. 195(4)
Long non-coding RNAs (lncRNAs) are involved in diverse biological processes, including DNA damage repair, and are of interest as potential biomarkers of radiosensitivity. We investigated whether lncRNA radiosensitivity signatures could be derived for
Autor:
Lingjian Yang, Patrick Shenjere, James P Wylie, Becky A.S. Bibby, Joely J Irlam, Helen R Valentine, Laura-Jane Forker, Michael G Leahy, Ananya Choudhury, Catharine M L West, Lucinda Billingham, Piers Gaunt, Martin Robinson
Publikováno v:
Radiotherapy and Oncology. 152:S39-S40