Increased Vascular Contractility in Hypertension Results From Impaired Endothelial Calcium Signaling

Autor: Calum, Wilson, Xun, Zhang, Charlotte, Buckley, Helen R, Heathcote, Matthew D, Lee, John G, McCarron

Publikováno v: Hypertension (Dallas, Tex. : 1979)

Supplemental Digital Content is available in the text.
Endothelial cells line all blood vessels and are critical regulators of vascular tone. In hypertension, disruption of endothelial function alters the release of endothelial-derived vasoactiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8a6c25c87462ae538a20152240e6ccc2
https://pubmed.ncbi.nlm.nih.gov/31542964

Mitochondrial ATP production provides long-range control of endothelial inositol trisphosphate-evoked calcium signaling

Autor: Calum, Wilson, Matthew D, Lee, Helen R, Heathcote, Xun, Zhang, Charlotte, Buckley, John M, Girkin, Christopher D, Saunter, John G, McCarron

Publikováno v: The Journal of Biological Chemistry

Endothelial cells are reported to be glycolytic and to minimally rely on mitochondria for ATP generation. Rather than providing energy, mitochondria in endothelial cells may act as signaling organelles that control cytosolic Ca2+ signaling or modify

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3f9a294cbef888d8edd2afac53700f0b
https://pubmed.ncbi.nlm.nih.gov/30498088

The Pharmacology of TUG-891, a Potent and Selective Agonist of the Free Fatty Acid Receptor 4 (FFA4/GPR120), Demonstrates Both Potential Opportunity and Possible Challenges to Therapeutic Agonism

Autor: Elisabeth Christiansen, Graeme Milligan, Brian D. Hudson, Andrew B. Tobin, John D. Pediani, Adrian J. Butcher, Helen R. Heathcote, Bharat Shimpukade, Trond Ulven, Amanda E. Mackenzie

Publikováno v: Hudson, B D, Shimpukade, B, Mackenzie, A E, Butcher, A J, Pediani, J D, Christiansen, E, Heathcote, H, Tobin, A B, Ulven, T & Milligan, G 2013, ' The Pharmacology of TUG-891, a Potent and Selective Agonist of the Free Fatty Acid Receptor 4 (FFA4/GPR120), Demonstrates Both Potential Opportunity and Possible Challenges to Therapeutic Agonism ', Molecular Pharmacology, vol. 84, no. 5, pp. 710-725 . https://doi.org/10.1124/mol.113.087783

TUG-891 [3-(4-((4-fluoro-4'-methyl-[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoic acid] was recently described as a potent and selective agonist for the long chain free fatty acid (LCFA) receptor 4 (FFA4; previously G protein-coupled receptor 120, or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dea98b367c12f1f11746df1816d099e
https://europepmc.org/articles/PMC3807074/