Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Helen R. Clark"'
Autor:
Helen R. Clark, Connor McKenney, Nathan M. Livingston, Ariel Gershman, Seema Sajjan, Isaac S. Chan, Andrew J. Ewald, Winston Timp, Bin Wu, Abhyudai Singh, Sergi Regot
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Fine tuning the immune response in line with the degree of threat is central to recognition of a pathogen versus commensal bacteria. Here the authors implicate a digital all-or-nothing cell response in control of the tissue level immune response.
Externí odkaz:
https://doaj.org/article/c941a781c5064d999cddc94eed6d7777
Publikováno v:
mSphere, Vol 4, Iss 1 (2019)
ABSTRACT Aspergillus fumigatus is a ubiquitous mold that produces small airborne conidia capable of traversing deep into the respiratory system. Recognition, processing, and clearance of A. fumigatus conidia by bronchial airway epithelial cells are t
Externí odkaz:
https://doaj.org/article/8cec9c6533634041ac9645a710309713
Autor:
Brett M. Tyler, Shiv D. Kale, Qunqing Wang, Kai Tao, Helen R. Clark, Kelly Drews, Vincenzo Antignani, Amanda Rumore, Tristan Hayes, Jonathan M. Plett, Isabelle Fudal, Biao Gu, Qinghe Chen, Katharyn J. Affeldt, Erwin Berthier, Gregory J. Fischer, Daolong Dou, Weixing Shan, Nancy P. Keller, Francis Martin, Thierry Rouxel, Christopher B. Lawrence
Publikováno v:
Molecular Plant-Microbe Interactions, Vol 26, Iss 6, Pp 611-616 (2013)
A wide diversity of pathogens and mutualists of plant and animal hosts, including oomycetes and fungi, produce effector proteins that enter the cytoplasm of host cells. A major question has been whether or not entry by these effectors can occur indep
Externí odkaz:
https://doaj.org/article/88878cef36a743e891ae00dc0180b6fc
Publikováno v:
eLife, Vol 9 (2020)
A large fraction of human cancers contain genetic alterations within the Mitogen Activated Protein Kinase (MAPK) signaling network that promote unpredictable phenotypes. Previous studies have shown that the temporal patterns of MAPK activity (i.e. si
Externí odkaz:
https://doaj.org/article/fb4b9c60b8f043069e467879fa0fa195
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
A large fraction of human cancers contain genetic alterations within the Mitogen Activated Protein Kinase (MAPK) signaling network that promote unpredictable phenotypes. Previous studies have shown that the temporal patterns of MAPK activity (i.e. si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2539a238577afdef55ed5a0790d923fb
https://elifesciences.org/articles/60541
https://elifesciences.org/articles/60541
Autor:
Ariel Gershman, Isaac S. Chan, Helen R. Clark, Abhyudai Singh, Nathan M. Livingston, Connor McKenney, Andrew J. Ewald, Sergi Regot, Seema Sajjan, Bin Wu, Winston Timp
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
To prevent damage to the host or its commensal microbiota, epithelial tissues must match the intensity of the immune response to the severity of a biological threat. Toll-like receptors allow epithelial cells to identify microbe associated molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::febd80697f9fe6657bc996baf8808f84
https://pubmed.ncbi.nlm.nih.gov/33758175
https://pubmed.ncbi.nlm.nih.gov/33758175
Epithelial tissues are constantly challenged by individual cell fate decisions while maintaining barrier function. During oncogenesis, mutant and normal cells also differ in their signaling states and cellular behaviors creating competitive interacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8584acfb0701d0926980020178daac61
Autor:
Markus W. Covert, Miriam V. Gutschow, Helen R. Clark, Mialy M. DeFelice, Jacob J. Hughey, Inbal Maayan, Takamasa Kudo, Sergi Regot
Publikováno v:
Science signaling. 12(579)
Over the last decade, multiple studies have shown that signaling proteins activated in different temporal patterns—such as oscillatory, transient, and sustained—can result in distinct gene expression patterns or cell fates. However, the molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e40f11a2c8be52c7acbfb1e18359142
https://pubmed.ncbi.nlm.nih.gov/31040261
https://pubmed.ncbi.nlm.nih.gov/31040261
Publikováno v:
mSphere, Vol 4, Iss 1 (2019)
mSphere, Vol 4, Iss 1, p e00663-18 (2019)
mSphere
mSphere, Vol 4, Iss 1, p e00663-18 (2019)
mSphere
Conidia from the fungus Aspergillus fumigatus are notorious for their ability to stay airborne. This characteristic is believed to allow conidia to penetrate into the cleanest environments. Several hundred conidia are thought to be inhaled each day b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b93a1e92a5cc02fd6620764e367482d
https://journals.asm.org/doi/10.1128/mSphere.00663-18
https://journals.asm.org/doi/10.1128/mSphere.00663-18