Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Helen R Saibil"'
Autor:
Ardan Patwardhan, Robert Brandt, Sarah J Butcher, Lucy Collinson, David Gault, Kay Grünewald, Corey Hecksel, Juha T Huiskonen, Andrii Iudin, Martin L Jones, Paul K Korir, Abraham J Koster, Ingvar Lagerstedt, Catherine L Lawson, David Mastronarde, Matthew McCormick, Helen Parkinson, Peter B Rosenthal, Stephan Saalfeld, Helen R Saibil, Sirarat Sarntivijai, Irene Solanes Valero, Sriram Subramaniam, Jason R Swedlow, Ilinca Tudose, Martyn Winn, Gerard J Kleywegt
Publikováno v:
eLife, Vol 6 (2017)
The integration of cellular and molecular structural data is key to understanding the function of macromolecular assemblies and complexes in their in vivo context. Here we report on the outcomes of a workshop that discussed how to integrate structura
Externí odkaz:
https://doaj.org/article/894e26f1fe364e90b4d2256c2a6eedf1
Autor:
Natalya Lukoyanova, Stephanie C Kondos, Irene Farabella, Ruby H P Law, Cyril F Reboul, Tom T Caradoc-Davies, Bradley A Spicer, Oded Kleifeld, Daouda A K Traore, Susan M Ekkel, Ilia Voskoboinik, Joseph A Trapani, Tamas Hatfaludi, Katherine Oliver, Eileen M Hotze, Rodney K Tweten, James C Whisstock, Maya Topf, Helen R Saibil, Michelle A Dunstone
Publikováno v:
PLoS Biology, Vol 13, Iss 2, p e1002049 (2015)
Membrane attack complex/perforin-like (MACPF) proteins comprise the largest superfamily of pore-forming proteins, playing crucial roles in immunity and pathogenesis. Soluble monomers assemble into large transmembrane pores via conformational transiti
Externí odkaz:
https://doaj.org/article/61da81d52f214c008c291f4ba889cd9a
Autor:
Carl Leung, Natalya V Dudkina, Natalya Lukoyanova, Adrian W Hodel, Irene Farabella, Arun P Pandurangan, Nasrin Jahan, Mafalda Pires Damaso, Dino Osmanović, Cyril F Reboul, Michelle A Dunstone, Peter W Andrew, Rana Lonnen, Maya Topf, Helen R Saibil, Bart W Hoogenboom
Publikováno v:
eLife, Vol 4 (2015)
Externí odkaz:
https://doaj.org/article/3ccb4083d8e948e290b3b3a5965a0e9c
Autor:
Carl Leung, Natalya V Dudkina, Natalya Lukoyanova, Adrian W Hodel, Irene Farabella, Arun P Pandurangan, Nasrin Jahan, Mafalda Pires Damaso, Dino Osmanović, Cyril F Reboul, Michelle A Dunstone, Peter W Andrew, Rana Lonnen, Maya Topf, Helen R Saibil, Bart W Hoogenboom
Publikováno v:
eLife, Vol 3 (2014)
Membrane attack complex/perforin/cholesterol-dependent cytolysin (MACPF/CDC) proteins constitute a major superfamily of pore-forming proteins that act as bacterial virulence factors and effectors in immune defence. Upon binding to the membrane, they
Externí odkaz:
https://doaj.org/article/95f4b1baef534ae3afce743c4f6eaf48
Autor:
Marta Carroni, Eva Kummer, Yuki Oguchi, Petra Wendler, Daniel K Clare, Irmgard Sinning, Jürgen Kopp, Axel Mogk, Bernd Bukau, Helen R Saibil
Publikováno v:
eLife, Vol 3 (2014)
The hexameric AAA+ chaperone ClpB reactivates aggregated proteins in cooperation with the Hsp70 system. Essential for disaggregation, the ClpB middle domain (MD) is a coiled-coil propeller that binds Hsp70. Although the ClpB subunit structure is know
Externí odkaz:
https://doaj.org/article/a9145d0f6eb74b92badedf42e5a4d329
Autor:
Melissa N. Hart, Franziska Mohring, Sophia M. DonVito, James A. Thomas, Nicole Muller-Sienerth, Gavin J. Wright, Ellen Knuepfer, Helen R. Saibil, Robert W. Moon
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Invasion of red blood cells (RBCs) by Plasmodium merozoites is critical to their continued survival within the host. Two major protein families, the Duffy binding-like proteins (DBPs/EBAs) and the reticulocyte binding like proteins (RBLs/RHs
Externí odkaz:
https://doaj.org/article/c48e41643e4c4f30a28ba70dc114bca3
Autor:
Guendalina Marini, Brad Poland, Chris Leininger, Natalya Lukoyanova, Dan Spielbauer, Jennifer K. Barry, Dan Altier, Amy Lum, Eric Scolaro, Claudia Pérez Ortega, Nasser Yalpani, Gary Sandahl, Tim Mabry, Jeffrey Klever, Timothy Nowatzki, Jian-Zhou Zhao, Amit Sethi, Adane Kassa, Virginia Crane, Albert L. Lu, Mark E. Nelson, Narayanan Eswar, Maya Topf, Helen R. Saibil
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The broad adoption of transgenic crops has revolutionized agriculture. However, resistance to insecticidal proteins by agricultural pests poses a continuous challenge to maintaining crop productivity and new proteins are urgently needed to r
Externí odkaz:
https://doaj.org/article/d2784a4f824b4587ab65f58ba0743143
Autor:
Szymon W. Manka, Wenjuan Zhang, Adam Wenborn, Jemma Betts, Susan Joiner, Helen R. Saibil, John Collinge, Jonathan D. F. Wadsworth
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
High-resolution structures of mammalian prions have remained elusive. Here, Manka et al. report the cryo-EM structure of infectious RML prion fibrils from mice. Structural similarity with recently reported infectious 263K prion fibrils from hamsters
Externí odkaz:
https://doaj.org/article/9b6eb942195b4bc19be04c9aa47b9d02
Autor:
Szymon W. Manka, Adam Wenborn, Jemma Betts, Susan Joiner, Helen R. Saibil, John Collinge, Jonathan D.F. Wadsworth
Publikováno v:
Nature Chemical Biology. 19:607-613
Recent cryogenic electron microscopy (cryo-EM) studies of infectious, ex vivo, prion fibrils from hamster 263K and mouse RML prion strains revealed a similar, parallel in-register intermolecular β-sheet (PIRIBS) amyloid architecture. Rungs of the fi
Autor:
Scott Gardner, Michele C. Darrow, Natalya Lukoyanova, Konstantinos Thalassinos, Helen R. Saibil
The bacterial chaperonin GroEL-GroES promotes protein folding through ATP-regulated cycles of substrate protein binding, encapsulation, and release. Here, we have used cryoEM to determine structures of GroEL, GroEL-ADP.BeF3, and GroEL-ADP.AlF3-GroES
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24317f24acf8dba81f1ccde9da36ad3f
https://doi.org/10.1101/2023.05.29.542693
https://doi.org/10.1101/2023.05.29.542693